Supramolecular Polymers Based on the Quadruplex Formation of Ditopic Guanosine Macromonomers in Nonaqueous Media

Abstract

The formation of supramolecular polymeric aggregates with a molecular mass of 100 kDa in a nonaqueous solution from a telechelic dimer of isopropylidene guanosine in the presence of K(+) ions is reported. The possible structure of macromonomers resulting from the development of G4 quartets was deduced from DOSY NMR, circular dichroism spectra, and dynamic light scattering measurements.

3-Substituted xanthines as promising candidates for quadruplex formation: computational, synthetic and analytical studies

“…As an internal mass reference, tetramethylsilane was used because of its inertness and spherical structure. 43,44 As an apparent MW, 920 Da was obtained in DMSO-d 6 solution at 300 K. For a (3MX) 4 aggregate, MW = 664 Da is expected, and the difference between the experimental and theoretical values may be attributed to solvent molecules associated with the clusters of 3MX. When 0.4 equiv.…”

Reversible organogels triggered by dynamic K+ binding and release

“…2 0 ,3 0 -Isopropylidene guanosine (3) and 2 0 ,3 0 -Isopropylidene guanosine hemisuccinate (4) were prepared as described in Refs. [49,50]. dry CH 2 Cl 2 (50 mL) was added.…”

Challenges and breakthroughs in recent research on self-assembly

“…Shimizu and corworkers synthesized porous apohost structures through self-assembly of bis-urea macrocycles and evaluated their guest inclusion properties [504]. Hydrogen-bond-based supramolecular polymers were fabricated through quadruplex-type self-assembly of ditopic guanosine macromonomers [505]. Fibrous nanostructures were found with hydrogen-bond-type self assembly of bis(2,6-diacylaminopyridine) derivatives [506], benzene-1,3,5-tricarboxamides [507], and pyromellitamide [508].…”