Supratentorial pure cortical ependymoma

Nakamizo, Satoshi; Sasayama, Takashi; Kondoh, Takeshi; Inoue, Satoshi; Shiomi, Ryoji; Tanaka, Hirotomo; Nishihara, Masamitsu; Mizukawa, Katu; Uehara, Keiichiro; Usami, Yu; Kohmura, Eiji

doi:10.1016/j.jocn.2011.09.039

Cited by 17 publications

(19 citation statements)

References 12 publications

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“…Only total tumor resection is considered as a reliable prognostic factor for predicting longer survival time [2, 3, 12, 16]. Of patients with no radiologic evidence of residual tumor, 75% ± 15% will remain tumor free after 5 years as opposed to the group of patients with residual disease in which progression cannot be stopped [5, 9, 17]. …”

Section: Discussionmentioning

confidence: 99%

“…Age at presentation is also a significant prognostic factor [5, 9, 17]. Patients younger than 3 years have a significantly worse outcome than older children or adults [8, 16, 17].…”

Section: Discussionmentioning

confidence: 99%

“…Postoperative radiation therapy must be administered in every case of partially resected ependymomas or anaplastic tumors. Chemotherapy and prophylactic craniospinal irradiation are not indicate as adjuvant treatment [5, 7, 8, 16]. …”

Section: Discussionmentioning

confidence: 99%

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Purely Cortical Anaplastic Ependymoma

Romero

Zanini

Ducati

et al. 2012

Case Reports in Oncological Medicine

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Ependymomas are glial tumors derived from ependymal cells lining the ventricles and the central canal of the spinal cord. It may occur outside the ventricular structures, representing the extraventicular form, or without any relationship of ventricular system, called ectopic ependymona. Less than fifteen cases of ectopic ependymomas were reported and less than five were anaplastic. We report a rare case of pure cortical ectopic anaplastic ependymoma.

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Section: Discussionmentioning

confidence: 99%

“…Age at presentation is also a significant prognostic factor [5, 9, 17]. Patients younger than 3 years have a significantly worse outcome than older children or adults [8, 16, 17].…”

Section: Discussionmentioning

confidence: 99%

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Purely Cortical Anaplastic Ependymoma

Romero

Zanini

Ducati

et al. 2012

Case Reports in Oncological Medicine

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“…Ultimately, clinical data were obtained from 27 of 53 articles, and 101 patients from the literature were identified. 3,[4][5][6][7]11,[13][14][15]17,18,[24][25][26][27][28][29]34,35,[40][41][42]44,49,52,53,58 Article authors were not contacted for additional data. A total of 109 patients from both study populations were included in our investigation, and 77 patients had complete clinical information as described below.…”

Section: Methods Patient Population and Article Selectionmentioning

confidence: 99%

Supratentorial hemispheric ependymomas: an analysis of 109 adults for survival and prognostic factors

Hollon¹,

Nguyen

Smith³

et al. 2016

JNS

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IntracranIal ependymomas are the third most common glioma in adults, behind astrocytomas and oligodendrogliomas. Ependymomas constitute 3% of primary CNS tumors and 6.7% of gliomas diagnosed each year in the US. 31,32 Safe maximal resection remains the mainstay of treatment. Radiation and chemotherapy may be provided as adjuvant treatments, especially in the setting of subtotal resection (STR). Reported 5-year overall survival (OS) rates for adults with intracranial ependymoma range widely from 35% to 90%. 9,19,21,47,54 Controversy exists regarding important prognostic factors for progression-free survival (PFS) and OS. 1,37,57 Reported prognostic factors include age, Karnofsky performance status, tumor location, tumor grade, extent of resection (EOR), and postoperative radiation. 8,9,[19][20][21][22][46][47][48]54 Evidence supports the idea that supratentorial ependymomas have a worse prognosis than infratentorial tumors do in adults. 9,19,20,23,38,45,46 Additional data indicate that patients with hemispheric ependymomas have decreased PFS and OS compared with tumors occurring in the third or lateral ventricles. 9,45 Although often considered an intraventricular tumor, more than half of supratentorial epabbreviatioNs EOR = extent of resection; GTR = gross total resection; OS = overall survival; PFS = progression-free survival; STR = subtotal resection. obJective Survival rates and prognostic factors for supratentorial hemispheric ependymomas have not been determined. The authors therefore designed a retrospective study to determine progression-free survival (PFS), overall survival (OS), and prognostic factors for hemispheric ependymomas. methods The study population consisted of 8 patients from our institution and 101 patients from the literature with disaggregated survival information (n = 109). Patient age, sex, tumor side, tumor location, extent of resection (EOR), tumor grade, postoperative chemotherapy, radiation, time to recurrence, and survival were recorded. Kaplan-Meier survival analyses and Cox proportional hazard models were completed to determine survival rates and prognostic factors. results Anaplastic histology/WHO Grade III tumors were identified in 62% of cases and correlated with older age. Three-, 5-, and 10-year PFS rates were 57%, 51%, and 42%, respectively. Three-, 5-, and 10-year OS rates were 77%, 71%, and 58%, respectively. EOR and tumor grade were identified on both Kaplan-Meier log-rank testing and univariate Cox proportional hazard models as prognostic for PFS and OS. Both EOR and tumor grade remained prognostic on multivariate analysis. Subtotal resection (STR) predicted a worse PFS (hazard ratio [HR] 4.764, p = 0.001) and OS (HR 4.216, p = 0.008). Subgroup survival analysis of patients with STR demonstrated a 5- and 10-year OS of 28% and 0%, respectively. WHO Grade III tumors also had worse PFS (HR 10.2, p = 0.004) and OS (HR 9.1, p = 0.035). Patients with WHO Grade III tumors demonstrated 5- and 10-year OS of 61% and 46%, respectively. Postoperative radiation was not prognostic f...

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“…Niazi et al held the kind of viewpoint that all patients with WHO grade III ependymoma required radiotherapy [10]. Postoperative radiotherapy should be executed in those patients with residual tumor and AEs [11]. On the other hand, prophylactic whole-spinal axis irradiation offers little utility in patients with localized supratentorial ependymomas, regardless of the tumor grade [12].…”

Section: Discussionmentioning

confidence: 99%