Surface characterization and in vivo evaluation of laser sintered and machined implants followed by resorbable-blasting media process: A study in sheep

Bowers, Michelle; Yoo, Doo-Yeol; Marin, Charles; Gil, Luiz Fernando; Shabaka, Nour; Goldstein, Matt; Tovar, Nick; Hirata, Ronaldo; Bonfante, Estevam A.; Coelho, Paulo G.

doi:10.4317/medoral.20946

Cited by 5 publications

(4 citation statements)

References 40 publications

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“…In contrast, Bowers et al [ 28 ] found no statistically significant difference in the BIC% of laser sintered and resorbable blasting media dental implants, installed in the mandible of six sheep, and retrieved after an undisturbed period of six weeks.…”

Section: Discussionmentioning

confidence: 93%

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Histological Evidence of the Osseointegration of Fractured Direct Metal Laser Sintering Implants Retrieved after 5 Years of Function

Mangano¹,

Mangano

Piattelli

et al. 2017

BioMed Research International

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Background. Direct metal laser sintering (DMLS) is an additive manufacturing technique that allows the fabrication of dental implants layer by layer through the laser fusion of titanium microparticles. The surface of DMLS implants is characterized by a high open porosity with interconnected pores of different sizes; therefore, it has the potential to enhance and accelerate bone healing. To date, however, there are no histologic/histomorphometric studies in the literature evaluating the interface between bone and DMLS implants in the long-term. Purpose. To evaluate the interface between bone and DMLS implants retrieved after 5 years of functional loading. Methods. Two fractured DMLS implants were retrieved from the human jaws, using a 5 mm trephine bur. Both the implants were clinically stable and functioned regularly before fracture. The specimens were processed for histologic/histomorphometric evaluation; the bone-to-implant contact (BIC%) was calculated. Results. Compact, mature lamellar bone was found over most of the DMLS implants in close contact with the implant surface; the histomorphometric evaluation showed a mean BIC% of 66.1% (±4.5%). Conclusions. The present histologic/histomorphometric study showed that DMLS implants were well integrated in bone, after 5 years of loading, with the peri-implant bone undergoing continuous remodeling at the interface.

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Section: Discussionmentioning

confidence: 93%

“…Several histologic and histomorphometric studies have investigated the osseointegration of DMLS titanium implants in different animal models [ 25 – 28 ].…”

Section: Discussionmentioning

confidence: 99%

Histological Evidence of the Osseointegration of Fractured Direct Metal Laser Sintering Implants Retrieved after 5 Years of Function

Mangano¹,

Mangano

Piattelli

et al. 2017

BioMed Research International

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“…This justifies the accomplishment of the two types of histomorphometric measurements in the present study (i.e., BIC and BAFO). Pre-clinical studies have shown that surface treatments producing micro roughness compared to machined surfaces increase BIC and BAFO [34,35,36]. In this sense, the present study aimed to verify if the creation of a nanostructured surface on a previously treated surface with double acid etching could maximize and accelerate the process of osseointegration by calculating BIC and BAFO [37].…”

Section: Discussionmentioning

confidence: 99%

Development of a Novel Nanotextured Titanium Implant. An Experimental Study in Rats

Pelegrine

Moy

Moshaverinia

et al. 2019

JCM

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This animal study evaluated the osseointegration level of a new nanotextured titanium surface produced by anodization. Ti-cp micro-implants (1.5 mm diameter by 2.5 mm in length) divided into two groups: titanium nanotextured surface treatment (Test Group) and acid etched surface treatment (Control Group). Surface characterization included morphology analysis using scanning electron microscopy and wettability by measuring contact angle. Sixteen Wistar rats were submitted to two micro implants surgical placement procedures. In each rat, one type of micro implant placed in each tibia. The animals sacrificed after two (T1) and six weeks (T2) post-implantation. After the euthanasia, tibias processed for histomorphometric analysis, which allowed the evaluation of bone to implant contact (BIC) and the bone area fraction occupancy between the threads (BAFO). Our surface analysis data showed that the Control Group exhibited an irregular and non-homogenous topography while the Test Group showed a nanotextured surface. The Test Group showed higher wettability (contact angle = 5.1 ± 0.7°) than the Control Group (contact angle = 75.5 ± 4.6°). Concerning the histomorphometric analysis results for T1, Control and Test groups showed BIC percentages of 41.3 ± 15.2% and 63.1 ± 8.7% (p < 0.05), respectively, and for BAFO, 28.7 ± 13.7% and 54.8 ± 7.5%, respectively (p < 0.05). For T2, the histomorphometric analysis for Control and Test groups showed BIC percentages of 51.2 ± 11.4% and 64.8 ± 7.4% (p < 0.05), respectively and for BAFO, 36.4 ± 10.3% and 57.9 ± 9.3% (p < 0.05), respectively. The findings of the current study confirmed that the novel nanotextured surface exhibited superior wettability, improved peri-implant bone formation, and expedited osseointegration.

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“…vivo studies, where the selected implant is planted inside an animal (cat, rat, rabbit, sheep, etc.) [74]; or even directly in human body. The porous Ti6Al4V scaffold prepared by EBM was favorable for bone ingrowth after implanted in sheep femoral [75].…”

Section: In-vivomentioning

confidence: 99%

Biomedical applications of additive manufacturing: Present and future

Singh

Ramakrishna

2017

Current Opinion in Biomedical Engineering

202

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Surface characterization and in vivo evaluation of laser sintered and machined implants followed by resorbable-blasting media process: A study in sheep

Cited by 5 publications

References 40 publications

Histological Evidence of the Osseointegration of Fractured Direct Metal Laser Sintering Implants Retrieved after 5 Years of Function

Histological Evidence of the Osseointegration of Fractured Direct Metal Laser Sintering Implants Retrieved after 5 Years of Function

Development of a Novel Nanotextured Titanium Implant. An Experimental Study in Rats

Biomedical applications of additive manufacturing: Present and future

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