Surface Modification of Highly Ordered Pyrolytic Graphite (HOPG) by a Mussel-Inspired Poly(norepinephrine) Coating: Characterizations and Cell Adhesion Test

Kang, Sung Min; Lee, Haeshin

doi:10.5012/bkcs.2013.34.3.960

Cited by 8 publications

(7 citation statements)

References 24 publications

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“…B), indicating the successful formation of PNE film on the PDMS surface using this simple and green one‐step self‐polymerization approach. Previous reports demonstrated that PNE can be formed and deposited on virtually any material surfaces as a permanent coating via the oxidation self‐polymerization of NE under alkaline conditions . Although the mechanism of NE polymerization is not exactly understood up to now, there is no denying that, at weak alkaline pH, dihydroxyl group protons in NE are deprotonated, subsequently further oxidation and rearrangement leads to form the major intermediate, the 3,5,6‐trihydroxyindole, whose further oxidation induces intermolecular cross‐linking to yield a polymer that is structurally similar to the bio‐pigment melanin (Fig.…”

Section: Resultsmentioning

confidence: 99%

One‐step preparation and application of mussel‐inspired poly(norepinephrine)‐coated polydimethylsiloxane microchip for separation of chiral compounds

Chen

Liang

et al. 2016

Electrophoresis

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In this paper, using the self-polymerization of norepinephrine (NE) and its favorable film-forming property, a simple and green preparation approach was developed to modify a PDMS channel for enantioseparation of chiral compounds. After the PDMS microchip was filled with NE solution, poly(norepinephrine) (PNE) film was gradually formed and deposited on the inner wall of microchannel as permanent coating via the oxidation of NE by the oxygen dissolved in the solution. Due to possessing plentiful catechol and amine functional groups, the PNE-coated PDMS microchip exhibited much better wettability, more stable and suppressed EOF, and less nonspecific adsorption. The water contact angle and EOF of PNE-coated PDMS substrate were measured to be 13° and 1.68 × 10(-4) cm(2) V(-1) s(-1) , compared to those of 108° and 2.24 × 10(-4) cm(2) V(-1) s(-1) from the untreated one, respectively. Different kinds of chiral compounds, such as amino acid enantiomer, drug enantiomer, and peptide enantiomer were efficiently separated utilizing a separation length of 37 mm coupled with in-column amperometric detection on the PNE-coated PDMS microchips. This facile mussel-inspired PNE-based microchip system exhibited strong recognition ability, high-performance, admirable reproducibility, and stability, which may have potential use in the complex biological analysis.

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Section: Resultsmentioning

confidence: 99%

One‐step preparation and application of mussel‐inspired poly(norepinephrine)‐coated polydimethylsiloxane microchip for separation of chiral compounds

Chen

Liang

et al. 2016

Electrophoresis

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“…Recently, polynorepinephrine was deposited on electrospun nanofibers made from poly(lactic acid‐ co ‐caprolactone) yielding a biointerface for PC12 neuron‐like differentiation . as well as on highly ordered pyrolytic graphene …”

Section: Pdanas By Oxidative Polymerization Of Da Derivativesmentioning

confidence: 99%

Chemistry of polydopamine analogues

Mrówczyński

Markiewicz

Liebscher

2016

Polymer International

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Polydopamine analogues (PDANAs) extend the prospering field of polydopamine (PDA) considerably. They include additional functional groups providing altered properties interesting for various applications. PDANAs can be obtained by post functionalization of PDA, by oxidative polymerization of dopamine derivatives or by copolymerization of dopamine with dopamine derivatives, other monomers or reactive polymers. This review covers the state of the art and gives insight into the huge potential of the field to be explored in the future. © 2016 Society of Chemical Industry

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“…Recently, the neurotransmitter norepinephrine has been shown to functionalize virtually any material surface when it is oxidatively polymerized to produce poly(norepinephrine) (pNE) [22,23]. The pNE coating layer exhibits unique properties, such as ring-opening polymerization and the storage/release of nitric oxide [24].…”

Section: Introductionmentioning

confidence: 99%

The Promotion of Human Neural Stem Cells Adhesion Using Bioinspired Poly(norepinephrine) Nanoscale Coating

Park

Shin

Kim

et al. 2014

Journal of Nanomaterials

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The establishment of versatile biomaterial interfaces that can facilitate cellular adhesion is crucial for elucidating the cellular processes that occur on biomaterial surfaces. Furthermore, biomaterial interfaces can provide physical or chemical cues that are capable of stimulating cellular behaviors by regulating intracellular signaling cascades. Herein, a method of creating a biomimetic functional biointerface was introduced to enhance human neural stem cell (hNSC) adhesion. The hNSC-compatible biointerface was prepared by the oxidative polymerization of the neurotransmitter norepinephrine, which generates a nanoscale organic thin layer, termed poly(norepinephrine) (pNE). Due to its adhesive property, pNE resulted in an adherent layer on various substrates, and pNE-coated biointerfaces provided a highly favorable microenvironment for hNSCs, with no observed cytotoxicity. Only a 2-hour incubation of hNSCs was required to firmly attach the stem cells, regardless of the type of substrate. Importantly, the adhesive properties of pNE interfaces led to micropatterns of cellular attachment, thereby demonstrating the ability of the interface to organize the stem cells. This highly facile surface-modification method using a biomimetic pNE thin layer can be applied to a number of suitable materials that were previously not compatible with hNSC technology.

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Surface Modification of Highly Ordered Pyrolytic Graphite (HOPG) by a Mussel-Inspired Poly(norepinephrine) Coating: Characterizations and Cell Adhesion Test

Cited by 8 publications

References 24 publications

One‐step preparation and application of mussel‐inspired poly(norepinephrine)‐coated polydimethylsiloxane microchip for separation of chiral compounds

One‐step preparation and application of mussel‐inspired poly(norepinephrine)‐coated polydimethylsiloxane microchip for separation of chiral compounds

Chemistry of polydopamine analogues

The Promotion of Human Neural Stem Cells Adhesion Using Bioinspired Poly(norepinephrine) Nanoscale Coating

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