Surface modification of PLGA nanofibrous biocomposites using flavonoids for biomedical applications

Xing, Zhicai; Koo, Tae-Hyung; Kim, Young‐Jin; Kwon, Oh-Hyeong; Kang, Inn‐Kyu

doi:10.1080/01694243.2012.697371

Cited by 5 publications

(7 citation statements)

References 31 publications

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“…It is noted that the electrospun pullulan/PVA/rutin nanofibrous mats had greater tensile stress than that of pullulan/PVA, and the ultimate tensile strength exhibited an increasing trend as the content of rutin increased, which indicated that the addition of rutin was capable of enhancing the mechanical properties of the nanofibrous mats. Rutin has stiff aromatic rings and ethylene dioxy rings in its structure [ 26 ]; meanwhile, rutin was capable of randomly dispersing in the electrospun nanofibers [ 22 ]. Thus, the addition of a limited amount of rutin can enhance the strength to some extent.…”

Section: Resultsmentioning

confidence: 99%

“…Rutin was found to be photo-stable and capable of enhancing the defense system against environment stresses, including low temperature, UV light, and desiccation [ 20 , 21 ]. Xing et al [ 22 ] proposed that rutin be added to poly( l -lactide- co -glycolide) (PLGA) solution and then electrospun to obtain antibacterial nanofibrous mats. However, reports related to the UV resistance of rutin-contained nanofibrous mats are scarce.…”

Section: Introductionmentioning

confidence: 99%

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Incorporation of Rutin in Electrospun Pullulan/PVA Nanofibers for Novel UV-Resistant Properties

Qian

Zheng

et al. 2016

Materials

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This study aimed to investigate the incorporation of rutin into electrospun pullulan and poly(vinyl alcohol) (PVA) nanofibers to obtain ultraviolet (UV)-resistant properties. The effect of weight ratios between pullulan and PVA, and the addition of rutin on the nanofibers’ morphology and diameters were studied and characterized by scanning electron microscopy (SEM). Fourier transform infrared (FTIR) analysis was utilized to investigate the interaction between pullulan and PVA, as well as with rutin. The results showed that the inclusion of PVA results in the increase in the fiber’s diameter. The addition of rutin had no obvious effect on the fibers’ average diameters when the content of rutin was less than 7.41%. FTIR results indicated that a hydrogen bond formed between pullulan and PVA, also between these polymers and rutin. Moreover, the addition of rutin could enhance the mechanical properties due to its stiff structure and could decrease the transmittance of UVA and UVB to be fewer than 5%; meanwhile, the value of ultraviolet protection factor (UPF) reached more than 40 and 50 when the content of rutin was 4.46% and 5.67%, respectively. Therefore, the electrospun pullulan/PVA/rutin nanofibrous mats showed excellent UV resistance and have potential applications in anti-ultraviolet packaging and dressing materials.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Incorporation of Rutin in Electrospun Pullulan/PVA Nanofibers for Novel UV-Resistant Properties

Qian

Zheng

et al. 2016

Materials

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“…PLGA, a polyester of hydroxy acids, is one the most biocompatible, biodegradable and injectable polymers approved by the FDA for many biomedical and therapeutic applications, ranging from DDSs to tissue engineering. [154][155][156] Although PLGA is a glassy synthetic polymer, it has a quite rigid structure along with remarkable mechanical strength, permitting its use as CDDSs. Besides, PLGA copolymers possess high ratios of lactic acid which are less hydrophilic than functional groups in PGA, absorbing less water and consequently are more slowly degradable.…”

Section: Applications Of Plga Blends In Cddssmentioning

confidence: 99%

<p>Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review</p>

Maghsoudi¹,

Shahraki²,

Rabiee³

et al. 2020

IJN

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With continual rapid developments in the biomedical field and understanding of the important mechanisms and pharmacokinetics of biological molecules, controlled drug delivery systems (CDDSs) have been at the forefront over conventional drug delivery systems. Over the past several years, scientists have placed boundless energy and time into exploiting a wide variety of excipients, particularly diverse polymers, both natural and synthetic. More recently, the development of nano polymer blends has achieved noteworthy attention due to their amazing properties, such as biocompatibility, biodegradability and more importantly, their pivotal role in controlled and sustained drug release in vitro and in vivo. These compounds come with a number of effective benefits for improving problems of targeted or controlled drug and gene delivery systems; thus, they have been extensively used in medical and pharmaceutical applications. Additionally, they are quite attractive for wound dressings, textiles, tissue engineering, and biomedical prostheses. In this sense, some important and workable natural polymers (namely, chitosan (CS), starch and cellulose) and some applicable synthetic ones (such as poly-lactic-co-glycolic acid (PLGA), poly(lactic acid) (PLA) and poly-glycolic acid (PGA)) have played an indispensable role over the last two decades for their therapeutic effects owing to their appealing and renewable biological properties. According to our data, this is the first review article highlighting CDDSs composed of diverse natural and synthetic nano biopolymers, blended for biological purposes, mostly over the past five years; other reviews have just briefly mentioned the use of such blended polymers. We, additionally, try to make comparisons between various nano blending systems in terms of improved sustained and controlled drug release behavior.

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“…PLGA-based drug delivery systems can be easily formed into any shape and size, such as particles, fibres, scaffolds, films, and coatings, and they can be used to incorporate and deliver a wide range of synthetic and natural drugs [ 10 , 11 ]. Numerous hydrophobic agents have been incorporated into PLGA matrices with proven antimicrobial efficiency, for example, chlorhexidine [ 12 ], essential oils from clove [ 13 ] or thyme [ 14 ], the flavonoids quercetin [ 15 ] and rutin [ 16 ], the monoterpenes carvone [ 17 ] and carvacrol [ 18 ], the phenylpropanoids anethole [ 17 ], cinnamaldehyde [ 19 ], and eugenol [ 19 ], a plant extract from guabiroba [ 20 ], and the steroid-like antibiotic fusidic acid [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Quantitative Assessment of Antimicrobial Activity of PLGA Films Loaded with 4-Hexylresorcinol

Kemme

Heinzel‐Wieland

2018

JFB

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Profound screening and evaluation methods for biocide-releasing polymer films are crucial for predicting applicability and therapeutic outcome of these drug delivery systems. For this purpose, we developed an agar overlay assay embedding biopolymer composite films in a seeded microbial lawn. By combining this approach with model-dependent analysis for agar diffusion, antimicrobial potency of the entrapped drug can be calculated in terms of minimum inhibitory concentrations (MICs). Thus, the topical antiseptic 4-hexylresorcinol (4-HR) was incorporated into poly(lactic-co-glycolic acid) (PLGA) films at different loadings up to 3.7 mg/cm2 surface area through a solvent casting technique. The antimicrobial activity of 4-HR released from these composite films was assessed against a panel of Gram-negative and Gram–positive bacteria, yeasts and filamentous fungi by the proposed assay. All the microbial strains tested were susceptible to PLGA-4-HR films with MIC values down to 0.4% (w/w). The presented approach serves as a reliable method in screening and quantifying the antimicrobial activity of polymer composite films. Moreover, 4-HR-loaded PLGA films are a promising biomaterial that may find future application in the biomedical and packaging sector.

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Surface modification of PLGA nanofibrous biocomposites using flavonoids for biomedical applications

Cited by 5 publications

References 31 publications

Incorporation of Rutin in Electrospun Pullulan/PVA Nanofibers for Novel UV-Resistant Properties

Incorporation of Rutin in Electrospun Pullulan/PVA Nanofibers for Novel UV-Resistant Properties

<p>Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review</p>

Quantitative Assessment of Antimicrobial Activity of PLGA Films Loaded with 4-Hexylresorcinol

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