Surface modification of polyetherurethaneureas and their antithrombogenicity

Kang, Inn‐Kyu; Kwon, Oh Hyeong; Byun, K. H.; Kim, Y. H.

doi:10.1007/bf00121251

Cited by 25 publications

(9 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a result of such treatment, the activation of plasma proteins and platelets has been effectively suppressed and the material with good in vitro blood compatibility has been obtained. 28 It had been noted several years ago that grafting of PEO onto the surface of biomer improves its blood compatibility. 29 Realizing their importance, in the present study, two monomers viz.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of methoxypolyethyleneglycol and lauric acid grafted novel polyurethanes for controlled release of nifedipine

Shelke

Aminabhavi

2007

J of Applied Polymer Sci

View full text Add to dashboard Cite

Novel polyurethanes (PUs) grafted with methoxypolyethyleneglycol (mPEG) and lauric acid (LA) were synthesized by solution polymerization using dibutyl tin dilaurate as a catalyst, taking different molar ratios of LA-trimethylol propane (LA-TMP) with respect to mPEGtrimethylol propane (mPEG-TMP). The polymers obtained were characterized by Fourier transform infrared spectroscopy and gel permeation chromatography to confirm, respectively, the PU formation and molecular weight. Moderate molecular-weight PUs were obtained, and nifedipine (NFD)-loaded microspheres were prepared by solvent evaporation method. The size of the microspheres as measured by laser light scattering technique ranged between 10 and 50 mm. An increase in the size of particles was observed with an increasing molar ratio of mPEG-TMP with respect to LA-TMP. The % encapsulation efficiency was found to vary between 65 and 92. The surface morphology of microspheres as studied by scanning electron microscopy revealed the spherical nature of the particles with wrinkles on their surfaces. Crystalline nature of the drug in the microspheres after loading was studied by X-ray diffraction technique. The release of NFD through the matrix microspheres was investigated in pH-7.4 phosphate buffer. An increase in release rate was observed with increasing molar ratio of mPEG-TMP with respect to LA-TMP.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of methoxypolyethyleneglycol and lauric acid grafted novel polyurethanes for controlled release of nifedipine

Shelke

Aminabhavi

2007

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…The APTT reveals the bioactivity of the intrinsic blood coagulation factors and can be used to evaluate the antithrombogencity of biomaterials in vitro 25, 26. Figure 5 shows that the APTT of the La 2 O 3 films is a little longer than those of blood plasma and SS, indicating that activation of the intrinsic blood coagulation system is suppressed slightly.…”

Section: Resultsmentioning

confidence: 99%

Hemocompatibility and antibacterial properties of lanthanum oxide films synthesized by dual plasma deposition

Jing

Huang

Liu

et al. 2008

J Biomedical Materials Res

View full text Add to dashboard Cite

Lanthanum oxide (La(2)O(3)) films with good hemocompatibility and antibacterial properties have been fabricated using dual plasma deposition. X-ray photoelectron spectroscopy (XPS) shows that La exists in the +3 oxidation state. The band gap of the materials is determined to be 3.6 eV. Activated partial thromboplastin time (APTT) and blood platelet adhesion tests were used to evaluate the blood compatibility. The bacteria, Staphylococcus aureus, were used in plate counting tests to determine the surface antibacterial properties. The APTT is a little longer than those of blood plasma and stainless steel (SS). Furthermore, the numbers of adhered, aggregated, and morphologically changed platelets are reduced compared with those on low-temperature isotropic carbon and SS. The antibacterial plate-counting test indicates that La(2)O(3) has good antibacterial activity against S. aureus. These unique hemocompatibility and antibacterial properties make La(2)O(3) useful in many biomedical applications.

show abstract

“…The aPTT test was widely used for the clinical detection of the abnormality of blood plasma and for the primary screening of the anticoagulative chemicals. 39 It was recently applied in the evaluation of the in vitro antithrombogenicity of biomaterials. 40,41 The aPTT of pure PLGA and E-PLGA nanofiber membranes are presented in Figure 4B.…”

Section: In Vitro Antioxidant Activity and Hemocompatibilitymentioning

confidence: 99%

PLGA nanofiber membranes loaded with epigallocatechin-3-O-gallate are beneficial to prevention of postsurgical adhesions

Shin¹,

Yang²,

Lee³

et al. 2014

IJN

View full text Add to dashboard Cite

This study concentrates on the development of biodegradable nanofiber membranes with controlled drug release to ensure reduced tissue adhesion and accelerated healing. Nanofibers of poly(lactic- co -glycolic acid) (PLGA) loaded with epigallocatechin-3- O -gallate (EGCG), the most bioactive polyphenolic compound in green tea, were electrospun. The physicochemical and biomechanical properties of EGCG-releasing PLGA (E-PLGA) nanofiber membranes were characterized by atomic force microscopy, EGCG release and degradation profiles, and tensile testing. In vitro antioxidant activity and hemocompatibility were evaluated by measuring scavenged reactive oxygen species levels and activated partial thromboplastin time, respectively. In vivo antiadhesion efficacy was examined on the rat peritonea with a surgical incision. The average fiber diameter of E-PLGA membranes was approximately 300–500 nm, which was almost similar to that of pure PLGA equivalents. E-PLGA membranes showed sustained EGCG release mediated by controlled diffusion and PLGA degradation over 28 days. EGCG did not adversely affect the tensile strength of PLGA membranes, whereas it significantly decreased the elastic modulus and increased the strain at break. E-PLGA membranes were significantly effective in both scavenging reactive oxygen species and extending activated partial thromboplastin time. Macroscopic observation after 1 week of surgical treatment revealed that the antiadhesion efficacy of E-PLGA nanofiber membranes was significantly superior to those of untreated controls and pure PLGA equivalents, which was comparable to that of a commercial tissue-adhesion barrier. In conclusion, the E-PLGA hybrid nanofiber can be exploited to craft strategies for the prevention of postsurgical adhesions.

show abstract

Surface modification of polyetherurethaneureas and their antithrombogenicity

Cited by 25 publications

References 19 publications

Synthesis and characterization of methoxypolyethyleneglycol and lauric acid grafted novel polyurethanes for controlled release of nifedipine

Synthesis and characterization of methoxypolyethyleneglycol and lauric acid grafted novel polyurethanes for controlled release of nifedipine

Hemocompatibility and antibacterial properties of lanthanum oxide films synthesized by dual plasma deposition

PLGA nanofiber membranes loaded with epigallocatechin-3-O-gallate are beneficial to prevention of postsurgical adhesions

Contact Info

Product

Resources

About