Polyetherurethaneurea (PU) films were treated by oxygen plasma discharge followed by acrylic acid (AA) grafting. The carboxyl groups of the AA-grafted PU (PU-AA) surface were coupled with bovine serum albumin and heparin via water soluble carbodiimide. Surface characterization of the modified PUs was carried out by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy and electron spectroscopy for chemical analysis (ESCA). The amount of immobilized albumin and heparin on the PU surface was 1.8 and 1.5 gg/cm 2, respectively, as determined by the dye interaction method. Interactions between the surface-modified PUs and blood components such as plasma proteins and platelets were investigated to evaluate the blood compatibility of the samples. Plasma recalcification time (PRT) and activated partial thromboplastin time (APTT) of the albumin-immobilized PU (PU-AI) were almost the same as those of PU, while platelets were less adhered on the PU-AI than on PU. On the other hand, PRT and APTT of the PU-He were significantly longer than those of the PU, PU-AA, and PU-AI. Moreover, adhesion of platelets was effectively suppressed on the PU-He, leading to good in vitroblood compatibility.

ABSTRACT:Vinylbenzyl abietate (VBA) was synthesized by the reaction of 4-vinylbenzyl chloride with sodium abietate. VBA homopolymer and copolymers of VBA with methyl methacrylate (MMA) were prepared in benzene using azobisisobutyronitrile as an initiator. The compositions of the copolymers were measured with 1 H NMR. The monomer reactivity ratios were determined by Kelen-Tüdös plot. The reactivity of VBA for the copolymerization was much larger than that of MMA. The glass transition temperature and the initial decomposition temperature of the homopolymer were higher than those of the copolymers. The polymers with the abietic acid moiety were crosslinked with UV irradiation. This result means that VBA can be a vinyl monomer for the preparation of photocrosslinkable polymers.