Surface modification of titanium implants by pH-Responsive coating designed for Self-Adaptive antibacterial and promoted osseointegration

Zhang, Fanjun; Hu, Quanjun; Wei, Yuan; Meng, Weilin; Wang, Rong; Liu, Jingze; Nie, Yong; Luo, Rifang; Wang, Yunbing; Shen, Bin

doi:10.1016/j.cej.2022.134802

Cited by 31 publications

(16 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The designed material removes the electrostatic shield in the acidic environment in which the bacteria are located, and the QASs are exposed for sterilization. 191 (c) Alternatively, the pH-responsive degradable QASs are stable in the presence of bacteria and rapidly break down in a normal cellular environment. The establishment of more targeted systems to specifically identify bacteria will be a more promising direction for QASs to be applied to biological therapy.…”

Section: Prospects Of Qass Applicationsmentioning

confidence: 99%

“…(b) The QASs are shielded from the positive charge or pH response for “pseudotargeting” action. The designed material removes the electrostatic shield in the acidic environment in which the bacteria are located, and the QASs are exposed for sterilization . (c) Alternatively, the pH-responsive degradable QASs are stable in the presence of bacteria and rapidly break down in a normal cellular environment.…”

Section: Prospects Of Qass Applicationsmentioning

confidence: 99%

See 1 more Smart Citation

Quaternary Ammonium Salts: Insights into Synthesis and New Directions in Antibacterial Applications

Zhou

Zhou²,

Zhang

et al. 2023

Bioconjugate Chem.

View full text Add to dashboard Cite

The overuse of antibiotics has led to the emergence of a large number of antibiotic-resistant genes in bacteria, and increasing evidence indicates that a fungicide with an antibacterial mechanism different from that of antibiotics is needed. Quaternary ammonium salts (QASs) are a biparental substance with good antibacterial properties that kills bacteria through simple electrostatic adsorption and insertion into cell membranes/altering of cell membrane permeability. Therefore, the probability of bacteria developing drug resistance is greatly reduced. In this review, we focus on the synthesis and application of single-chain QASs, double-chain QASs, heterocyclic QASs, and gemini QASs (GQASs). Some possible structure–function relationships of QASs are also summarized. As such, we hope this review will provide insight for researchers to explore more applications of QASs in the field of antimicrobials with the aim of developing systems for clinical applications.

show abstract

Section: Prospects Of Qass Applicationsmentioning

confidence: 99%

Section: Prospects Of Qass Applicationsmentioning

confidence: 99%

Quaternary Ammonium Salts: Insights into Synthesis and New Directions in Antibacterial Applications

Zhou

Zhou²,

Zhang

et al. 2023

Bioconjugate Chem.

View full text Add to dashboard Cite

show abstract

“…The generation of ROS species on the titanium composite surface induced light response and reversible conformational change caused the thermo-responsive behavior [ 114 ]. A pH-sensitive, self–adaptive coating with antibacterial, anti-inflammatory, and osteointegration was reported by Fanjun Zhang et al [ 115 ]. The smart coating comprised of antibacterial co-polymer containing quaternary ammonium salts (QAs), which were coated on a titanium surface by layer self-assembly.…”

Section: Antibacterial Coatings On Titanium Implantsmentioning

confidence: 99%

Antibacterial Coatings for Titanium Implants: Recent Trends and Future Perspectives

et al. 2022

View full text Add to dashboard Cite

Titanium and its alloys are widely used as implant materials for biomedical devices owing to their high mechanical strength, biocompatibility, and corrosion resistance. However, there is a significant rise in implant-associated infections (IAIs) leading to revision surgeries, which are more complicated than the original replacement surgery. To reduce the risk of infections, numerous antibacterial agents, e.g., bioactive compounds, metal ions, nanoparticles, antimicrobial peptides, polymers, etc., have been incorporated on the surface of the titanium implant. Various coating methods and surface modification techniques, e.g., micro-arc oxidation (MAO), layer-by-layer (LbL) assembly, plasma electrolytic oxidation (PEO), anodization, magnetron sputtering, and spin coating, are exploited in the race to create a biocompatible, antibacterial titanium implant surface that can simultaneously promote tissue integration around the implant. The nature and surface morphology of implant coatings play an important role in bacterial inhibition and drug delivery. Surface modification of titanium implants with nanostructured materials, such as titanium nanotubes, enhances bone regeneration. Antimicrobial peptides loaded with antibiotics help to achieve sustained drug release and reduce the risk of antibiotic resistance. Additive manufacturing of patient-specific porous titanium implants will have a clear future direction in the development of antimicrobial titanium implants. In this review, a brief overview of the different types of coatings that are used to prevent implant-associated infections and the applications of 3D printing in the development of antibacterial titanium implants is presented.

show abstract

“…The colony counting method was used for the number of adhered bacteria on the surface to show the antiadhesion property of PBOZs. ,− The bacterial suspension (10 8 CFU/mL) was co-incubated with PBOZs for 6 h at 37 °C. The bacteria adhered on the surface of PBOZs were dispersed into phosphate-buffered saline buffer and then incubated on the solid agar plate at 37 °C for 12 h. The tests were repeated three times.…”

Section: Methodsmentioning

confidence: 99%

Benzoxazine Monomers with Antibacterial Property and Polybenzoxazines for Preventing Adhesion to Bacteria

Yuan

Wang

et al. 2023

ACS Appl. Polym. Mater.

View full text Add to dashboard Cite

A series of biobased benzoxazine monomers (TF-BOZs) were designed and synthesized using tyrosine methyl ester, furfural, and five amine sources through the Mannich condensation reaction. The structures of BOZs were examined using 1H NMR, 13C NMR, mass spectra (MS), and Fourier transform infrared spectra (FT-IR), which indicated the successful synthesis of TF-BOZ monomers. Curing behavior was studied, which revealed that BOZ monomers could form polybenzoxazine resins (PBOZs) via ring-opening polymerization. In addition, the PBOZs exhibited remarkable thermal stability, which is better than that of the traditional bisphenol A–aniline polybenzoxazine. The antibacterial properties and antibiofilm performances of the BOZs were investigated. The TF-BOZs showed significant broad-spectrum antibacterial activity against Gram-positive Staphylococcus aureus (S. aureus), Gram-negative Escherichia coli (E. coli), and Pseudomonas aeruginosa (P. aeruginosa). The BOZ-Ola exhibited the best antibacterial property with the minimum inhibitory concentration (MIC) of 5 μg/mL against S. aureus, which, based on the electrostatic interaction acts on the bacterial surface and hydrophobic interaction destroys cell membrane integrity. Notably, PBOZs exhibited significant resistance to bacterial adhesion because of their antimicrobial properties, stable hydrophobicity, and low surface energy, indicating their application potential as antifouling materials. Those results indicate the great potential of TF-BOZs and PBOZs as antibacterial agents and materials to solve bacterial contamination and expand the application range of sustainable materials.

show abstract

Surface modification of titanium implants by pH-Responsive coating designed for Self-Adaptive antibacterial and promoted osseointegration

Cited by 31 publications

References 48 publications

Quaternary Ammonium Salts: Insights into Synthesis and New Directions in Antibacterial Applications

Quaternary Ammonium Salts: Insights into Synthesis and New Directions in Antibacterial Applications

Antibacterial Coatings for Titanium Implants: Recent Trends and Future Perspectives

Benzoxazine Monomers with Antibacterial Property and Polybenzoxazines for Preventing Adhesion to Bacteria

Contact Info

Product

Resources

About