Surface plasmon resonance signal enhancement based on erlotinib loaded magnetic nanoparticles for evaluation of its interaction with human lung cancer cells

Mohammadzadeh-Asl, Saeideh; Aghanejad, Ayuob; Guárdia, Miguel de la; Dolatabadi, Jafar Ezzati Nazhad; Keshtkar, Ahmad

doi:10.1016/j.optlastec.2020.106521

Cited by 19 publications

(4 citation statements)

References 30 publications

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“…SPR sensors have many advantages, such as low cost [135], no labeling [136], require a low sample volume, real-time measurement [137], high sensitivity and specificity, and allow fast measurement [138][139][140][141]. They have increasing applications in the detection of various analytes in medical diagnosis, environmental monitoring, food safety, and so on [142][143][144][145][146].…”

Section: Surface Plasmon Resonancementioning

confidence: 99%

Recent Advances of Optical Sensors for Copper Ion Detection

2022

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A trace element copper (Cu2+) ion is the third most plentiful metal ion that necessary for all living organisms and playing a critical role in several processes. Nonetheless, according to cellular needs, deficient or excess Cu2+ ion cause various diseases. For all these reasons, optical sensors have been focused rapid Cu2+ ion detection in real-time with high selectivity and sensitivity. Optical sensors can measure fluorescence in the refractive index—adsorption from the relationships between light and matter. They have gained great attention in recent years due to the excellent advantages of simple and naked eye recognition, real-time detection, low cost, high specificity against analytes, a quick response, and the need for less complex equipment in analysis. This review aims to show the significance of Cu2+ ion detection and electively current trends in optical sensors. The integration of optical sensors with different systems, such as microfluidic systems, is mentioned, and their latest studies in medical and environmental applications also are depicted. Conclusions and future perspectives on these advances is added at the end of the review.

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Section: Surface Plasmon Resonancementioning

confidence: 99%

Recent Advances of Optical Sensors for Copper Ion Detection

2022

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“…Usually, the detection of EFGR using SPR sensors is limited due to the nature of its molecular size. Fortunately, the conjugation of magnetic nanoparticles (MNPS) to an erlotinib functionalised SPR sensor has demonstrated a mean signal amplifi-cation of about 2.5-fold for its interaction with EFGR (A549 lung cancer cells) compared to the erlotinib functionalised sensor [85]. Similarly, the sensitivity issue can be overcome by engineering a phase-based SPR sensor with an atomically thin two-dimensional film made from novel materials such as Ge 2 Sb 2 Te 5 [86].…”

Section: Spr Biosensors For the Detection Of Other Biomarkersmentioning

confidence: 99%

Plasmonic Biosensors for the Detection of Lung Cancer Biomarkers: A Review

et al. 2021

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Lung cancer is the most common and deadliest cancer type globally. Its early diagnosis can guarantee a five-year survival rate. Unfortunately, application of the available diagnosis methods such as computed tomography, chest radiograph, magnetic resonance imaging (MRI), ultrasound, low-dose CT scan, bone scans, positron emission tomography (PET), and biopsy is hindered due to one or more problems, such as phenotypic properties of tumours that prevent early detection, invasiveness, expensiveness, and time consumption. Detection of lung cancer biomarkers using a biosensor is reported to solve the problems. Among biosensors, optical biosensors attract greater attention due to being ultra-sensitive, free from electromagnetic interference, capable of wide dynamic range detection, free from the requirement of a reference electrode, free from electrical hazards, highly stable, capable of multiplexing detection, and having the potential for more information content than electrical transducers. Inspired by promising features of plasmonic sensors, including surface plasmon resonance (SPR), localised surface plasmon resonance (LSPR), and surface enhanced Raman scattering (SERS) such as ultra-sensitivity, single particle/molecular level detection capability, multiplexing capability, photostability, real-time measurement, label-free measurement, room temperature operation, naked-eye readability, and the ease of miniaturisation without sophisticated sensor chip fabrication and instrumentation, numerous plasmonic sensors for the detection of lung cancer biomarkers have been investigated. In this review, the principle plasmonic sensor is explained. In addition, novel strategies and modifications adopted for the detection of lung cancer biomarkers such as miRNA, carcinoembryonic antigen (CEA), cytokeratins, and volatile organic compounds (VOCs) using plasmonic sensors are also reported. Furthermore, the challenges and prospects of the plasmonic biosensors for the detection of lung cancer biomarkers are highlighted.

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“…Meanwhile, some nanoparticles, like gold nanoparticles (AuNPs) and magnetic nanoparticles, can be introduced in SPR sensor to increase response and improve sensitivity. 39,40 This assay integrates the strengths of aptamer and SPR analysis, and is suitable for real time and high throughput analysis. The aptamer-coated sensor chip is reusable and presents high stability, showing great potential for applications.…”

Section: Nse Detectionmentioning

confidence: 99%