Surface properties of poly(dimethylsiloxane)-based inorganic/organic hybrid materials

Li, Z Zhili; Han, Wei; Kozodaev, DA Dmitry; Brokken-Zijp, Jcm José; Thüne, PC Peter

doi:10.1016/j.polymer.2005.12.057

Cited by 58 publications

(43 citation statements)

References 33 publications

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Section: Characterization Of Capturing Surfacessupporting

confidence: 59%

“…In particular, the sample II presented the highest fluorine percentage as expected for the use of the double silane quantity in the functionalization protocol. Beside fluorine, the chemical composition has a relative percentage of carbon, oxygen and silicon compatible with the standard composition of PDMS, as reported in the literature [31,33,37] and evident for the control surface, which is native PDMS and did not received any functionalization step.The AFM images reported in Figure 2 clearly show the formation of the nano-holes pattern; while the surface of the native PDMS is smooth and does not evidence any topographic feature. In the patterned samples the nanometric holes are well visible and the inset in Figure 2B aims to show a profile of a single nano-hole from sample I.…”

supporting

confidence: 59%

“…XPS measurements were performed using a Scienta ESCA200 instrument equipped with a hemispherical analyzer and a monochromatic Al Kα (1486.6 eV) X-ray source, in transmission mode. The emission angle between the analyzer axis and the sample surface was 30°, corresponding to a sampling depth of approximately 5 nm [33]. For each sample Si 2p, O 1s, C 1s, and F 1s core lines were recorded, using the low electron energy flood gun to compensate sample charging.…”

mentioning

confidence: 99%

“…All surfaces were observed with a 20× magnification objective and measured with a cooled CCD camera (DFC 420C, Leica Microsystems, Germany). All fluorescence images were analyzed with Fiji software [33] in order to quantify the fluorescence of the adsorbed RNA. …”

mentioning

confidence: 99%

See 3 more Smart Citations

Enhancing miRNAs Capture on Polydimethylsiloxane Surface with Nanostructuration

Guida¹,

Savio²,

Potrich³

et al. 2017

J Nanomed Nanotechnol

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IntroductionIn the last years, predictive and preventive medicine took advantage on the novel discoveries in nano-diagnostics and smart therapies, mainly based on the specific identification of molecular biomarkers, such as nucleic acids (DNA, miRNA) and proteins. The possibility to detect low amount of biomarkers directly in biological fluids gives a great advantage in the early diagnosis and therapy of malignant diseases, which have high social impact. In fact, a correlation between degenerative, contagious, or inflammatory illnesses with the presence of specific biomarkers like miRNAs is now well established [1][2][3][4][5]. However, this remains a challenging task since in each biological sample several different biomolecular species co-exist, and moreover it is very hard to treat them in order to achieve the degree of purity and concentration required for a quantitative, specific, and reliable identification. To overcome these obstacles, several nanotechnologybased systems are being developed and tested for miRNAs detection. Nanobiosensor development is particularly relevant for such miRNAs, whose aberrant expression has been shown to correlate with the pathogenesis and progression of several diseases including cancer [6,7]. , in particular, is largely studied since is overexpressed in a variety of solid [8,9] and hematological tumors [10,11]. For these reasons, miR-21 was selected as a microRNA prototype in this study.Recently, it has been proposed that nanotechnology-based approaches [12][13][14] alternative to conventional methods [15][16][17][18][19] for miRNA detection and quantification can be developed using innovative biosensors made of Polydimetylsiloxane (PDMS) [20][21][22]. PDMS is known to have numerous advantages, supporting its development as a useful platform for biosensor and biomedical applications [20,[23][24][25]. Particularly, the attractiveness of such polymer lies in the fact that its chemical and physical properties and also the surface topography can be modulated [26]. These features combined with the manufacturing of biomolecule-specific topographies contribute to the improvement of PDMS performance in terms of sensitivity and efficiency. Recently, the fabrication of PDMS-based devices has introduced significant advances in several analytical techniques in terms of sensitivity, time consuming, and sample volume. Since PDMS material revealed characteristic properties and reliability, PDMS-nanotechnology has therefore gained great attention in developing new generation of research tools. However, both traditional and technology-based approaches have yet limitations mainly related to sample processing, purification, separation and enrichment of the small RNA fraction [12,27]. In fact, advanced biosensors still require specific conjugation steps [28] and expensive equipment which need to be overcome before they can have a real clinical application.PDMS nanostructures manufacturing may be useful to enhance the efficient purification of miRNA circulating bio-markers present at low Abstrac...

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Section: Characterization Of Capturing Surfacessupporting

confidence: 59%

supporting

confidence: 59%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Enhancing miRNAs Capture on Polydimethylsiloxane Surface with Nanostructuration

Guida¹,

Savio²,

Potrich³

et al. 2017

J Nanomed Nanotechnol

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“…Atomic Force Microscopy (AFM) has been largely employed for textural analysis of silica gel, [32][33] organic-inorganic hybrids prepared by the sol-gel method, [34][35] and for the study the mechanism of self-assembled monolayer growing of octadecyltrichlorosilane on oxidized silicon substrate. [36][37] In the present study, AFM was employed for the textural characterization in terms of surface morphology, and roughness of some silicas obtained by the sol-gel method.…”

Section: Effect Of the Teos/ods Molar Ratio On The Morphology And Texmentioning

confidence: 99%

Spherical and lamellar octadecylsilane hybrid silicas

Brambilla

Pires

Silveira

et al. 2008

Journal of Non-Crystalline Solids

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Preparation and morphology of transparent poly(methyl methacrylate)–poly(dimethylsiloxane) hybrid materials using multifunctional silicone macromonomer

Sugimoto

Nishino

Koyama

et al. 2011

J of Applied Polymer Sci

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In this study, transparent poly(methylmethacrylate) (PMMA)-silicone hybrid materials, P(MMA-coSigUMAx), were prepared with methylmethacrylate (MMA) and multifunctional silicone macromonomer introduced methacryl groups. The transmittance of hybrid materials improved with increase of methacryl groups of silicone macromonomer and reached around 90% T. Atomic force microscopic analysis, scanning electron microscope examinations, and copolymerization kinetics estimation by proton nuclear magnetic resonance revealed that the silicone macromonomer randomly incorporated in the copolymer with MMA by the increase of methacryl groups and suppresses the aggregation of the silicone segment. The hybrid materials introduced over 10 wt % of silicone component had watershedding surface and the water contact angle was elevated from 65 to 95. Though the mechanical properties of hybrid materials were lowered by introduction of flexible silicone component, thermal property such as 5 wt % weight loss temperature were improved.

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Surface properties of poly(dimethylsiloxane)-based inorganic/organic hybrid materials

Cited by 58 publications

References 33 publications

Enhancing miRNAs Capture on Polydimethylsiloxane Surface with Nanostructuration

Enhancing miRNAs Capture on Polydimethylsiloxane Surface with Nanostructuration

Spherical and lamellar octadecylsilane hybrid silicas

Preparation and morphology of transparent poly(methyl methacrylate)–poly(dimethylsiloxane) hybrid materials using multifunctional silicone macromonomer

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