Surgical management of traumatic retinal detachment with perfluorocarbon liquid

Soheilian, Masoud; Peyman, Gholam A.; Wafapoor, H.; Navarro, Greta C.; Thompson, Hilary W.

doi:10.1007/bf00131918

Cited by 33 publications

(2 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In comparison, silicone oil, sulfur hexafluoride, and perfluoropropane were used as tamponades with retinal reattachment rates of 77.9%, 88%, and 70%, respectively. 8 The better reattachment rate is primarily why PFCL was chosen over silicone oil for use as an intraocular tamponade.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Long-Term Use of a Temporary Keratoprosthesis and Perfluorocarbon in Traumatic Retinal Detachment Repair

Govindaraju

Trese

Gupta

et al. 2022

Journal of VitreoRetinal Diseases

View full text Add to dashboard Cite

Purpose: To present a technique for optimizing repair of traumatic retinal detachments (RDs). Methods: A patient was followed in an outpatient setting with clinical examinations, optical coherence tomography, widefield fundus photography, and anterior segment imaging. Results: The patient presented with a total RD after ruptured globe repair. The patient had combined corneal and retinal surgery with placement of a temporary keratoprosthesis (TKP) and vitrectomy with perfluorocarbon liquid (PFCL) to reattach the retina. The TKP and PFCL were left in the eye for 2 weeks before a planned silicone oil exchange and penetrating keratoplasty were performed. Four months postoperatively, the patient presented with a partially attached retina and improved vision. Conclusions: In this case, a ruptured globe decompensated several months after primary repair. The prolonged use of the TKP allowed for optimal surgical visualization, enhanced office-based assessment, and limited endothelial cell loss of the donor corneal tissue.

show abstract

Section: Discussionmentioning

confidence: 99%

“…7 There are previous reports of leaving PFCL in the eye postoperatively. Soheilian et al 8 describe traumatic RD after OGIs in a series of 6 cases with a 100% reattachment rate. In comparison, silicone oil, sulfur hexafluoride, and perfluoropropane were used as tamponades with retinal reattachment rates of 77.9%, 88%, and 70%, respectively.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Use of a Temporary Keratoprosthesis and Perfluorocarbon in Traumatic Retinal Detachment Repair

Govindaraju

Trese

Gupta

et al. 2022

Journal of VitreoRetinal Diseases

View full text Add to dashboard Cite

show abstract

Biocompatibility assessment of silicone oil and perfluorocarbon liquids used in retinal reattachment surgery in rat retinal cultures

Malchiodi-Albedi

Morgillo

Formisano

et al. 2002

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

The effects of silicone oil and perfluorocarbon liquids used in retinal reattachment surgery were studied in vitro using rat retinal cultures seeded on microporous inserts. These inserts allow the cell layer to be in contact with the material to be tested on the apical side and with the nutrient medium on the basal side. The materials tested were silicone oil, the perfluorocarbons perfluorophenanthrene and perfluoroctane, and hydroxypropylmethylcellulose. Perfluorophenanthrene, the heaviest of the compounds, induced a very precocious detachment of the cell layer. All the other tested biomaterials were compatible with cell survival and did not alter the structural organization of the retinal cultures, as revealed by scanning electron microscopy. By immunocytochemical techniques we evaluated the cell composition and the differentiation state of each of the cultures. In both control and treated samples, neuronal cells were well preserved. The expression of microtubule-associated protein 2, a marker of differentiated neuronal cytoskeleton, was not affected. Amacrine neurons, immunolabeled for gamma-aminobutyric acid, still were detectable after treatment. Synapses, marked by immunoreactivity for synapthophysin, were equally preserved. Vimentin-positive glial cells did not show modifications. The apoptotic rate, as determined by the terminal transferase-mediated dUTP-biotin nick end-labeling assay, was similar in treated and control samples. The results confirm that the use of biomaterials with a specific gravity close to intraocular fluids is compatible with retinal cell survival and differentiation in vitro.

show abstract

Perfluorohexyloctane (F6H8) induces structural modifications and increases apoptosis in rat primary retinal cultures

et al. 2003

View full text Add to dashboard Cite

The effects of perfluorohexyloctane (F6H8), recently investigated as a long-term artificial vitreous substitute, were studied in vitro, with the use of rat retinal cultures seeded on microporous inserts that allow the cell layer to be in contact with the material to be tested, on the apical side, and with the nutrient medium, on the basal side. After 72 h of treatment with F6H8, retinal cultures lost the characteristic two-layered organization with glial cells at the bottom and neuronal cells on top of them. They appeared to be composed of only one layer of polyhedrical, flattened, and disconnected cells. TUNEL assay revealed an evident increase in the percentage of apoptotic cells in F6H8-treated cultures (30.1 +/- 4.5), compared to control (10.3 +/- 2.6) and perfluoroctane-treated cultures (10.1 +/- 1.7). Immunolabeling of MAP-2, a protein of neuronal cytoskeleton, evidenced a marked loss of neurites. The results suggest that F6H8 is harmful to retinal cells in vitro and can therefore be potentially noxious to the retina as an artificial vitreous substitute.

show abstract

Surgical management of traumatic retinal detachment with perfluorocarbon liquid

Cited by 33 publications

References 44 publications

Long-Term Use of a Temporary Keratoprosthesis and Perfluorocarbon in Traumatic Retinal Detachment Repair

Long-Term Use of a Temporary Keratoprosthesis and Perfluorocarbon in Traumatic Retinal Detachment Repair

Biocompatibility assessment of silicone oil and perfluorocarbon liquids used in retinal reattachment surgery in rat retinal cultures

Perfluorohexyloctane (F6H8) induces structural modifications and increases apoptosis in rat primary retinal cultures

Contact Info

Product

Resources

About