Surgical Staging of Ovarian Low Malignant Potential Tumors

Rao, Gautam; Skinner, Elizabeth N.; Gehrig, Paola A.; Duska, Linda R.; Coleman, Robert L.; Schorge, John O.

doi:10.1097/01.aog.0000133484.92629.88

Cited by 57 publications

(30 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This figure is lower than that of Leake and co-workers but higher than that reported in recent studies 17,22,28 and is attributed to differences in study design and to evolving staging practices. Because we were interested in identifying histologic patterns of LNI, we included any patient with a primary ovarian S-LMP who had a lymph node sampled during initial staging, whether it was obtained during a formal surgical pelvic or paraaortic lymph node sampling procedure or incidentally during a staging procedure that included mesenteric/ omental or peritoneal biopsies.…”

Section: Discussioncontrasting

confidence: 69%

Lymph Node Involvement in Ovarian Serous Tumors of Low Malignant Potential (Borderline Tumors)

McKenney

Balzer

Longacre

2006

American Journal of Surgical Pathology

View full text Add to dashboard Cite

The occurrence of regional lymph node involvement (LNI) in patients with primary ovarian serous tumors of low malignant potential (S-LMP), although well described in the literature, continues to be problematic. Most studies indicate that LNI is not associated with an adverse prognosis, but there has not been a comprehensive study addressing the histologic patterns of LNI, the importance, if any, of classifying the type of LNI (ie, as either noninvasive or invasive in analogy to peritoneal implant classification), or the presence and significance of associated endosalpingiosis. To further evaluate LNI in S-LMP, 74 patients with ovarian S-LMP and a lymph node biopsy or sampling were studied. Thirty-one of 74 patients had LNI in pelvic (18; 58%), mesenteric/omental (9; 29%), paraaortic (8; 26%), or supradiaphragmatic (2; 6%) lymph nodes. The number of involved nodes ranged from 1 to 20 (mean, 11.1). Four patterns of LNI were identified: individual cells, clusters of cells, and simple, nonbranching papillae (28 of 31; 90%); intraglandular (21 of 31; 68%); cells with prominent cytoplasmic eosinophilia ("eosinophilic cell" pattern) (16 of 31; 52%); and micropapillary pattern (5 of 31; 16%). LNI was diffuse in at least one lymph node in 13 patients (42%) and formed nodular aggregates greater than 1 mm in 6 patients (19%). Nodal endosalpingiosis was present in 58% of cases with LNI compared with 35% without LNI (P=0.06). There was no significant difference in survival for patients with LNI compared with patients without LNI. However, the presence of discrete nodular aggregates of epithelium greater than 1 mm in linear dimension without intervening lymphoid tissue was associated with a statistically significant decreased disease-free survival when compared with other patterns of LNI (P=0.02). Nodular aggregates were strongly associated with desmoplastic fibrous stromal reaction (P=0.001) and micropapillary architecture (0.02). There was also a trend for decreased survival among patients with LNI without associated endosalpingiosis (56%) compared with patients with LNI associated with endosalpingiosis (85%) and those with endosalpingiosis only (93%). This study suggests that patients with ovarian S-LMP may be further substratified into risk categories by the presence of nodular aggregates of S-LMP in lymph nodes, a feature that is more common in cases with micropapillary architecture and associated stromal reaction in the intranodal tumor. This high risk pattern of LNI may have a predictive value similar to invasive peritoneal implants and deserves independent evaluation in future studies of S-LMP.

show abstract

Section: Discussioncontrasting

confidence: 69%

Lymph Node Involvement in Ovarian Serous Tumors of Low Malignant Potential (Borderline Tumors)

McKenney

Balzer

Longacre

2006

American Journal of Surgical Pathology

View full text Add to dashboard Cite

show abstract

“…In the present study, median age of patients who had conservative surgery was 29 years. In many other studies, it was said that conservative surgery in patients with BOT could be acceptable (22)(23)(24). In our study, only one patient who had USO in the initial surgery (conservative group) had recurrence.…”

Section: Discussionmentioning

confidence: 43%

Mucinous borderline ovarian tumors: Analysis of 75 patients from a single center

Kavak

Üreyen

Karalök

et al. 2016

J Turkish German Gynecol Assoc

View full text Add to dashboard Cite

“…Cependant, plusieurs études n'ont pas retrouvé de bénéfice à cette chirurgie de stadification complète [34][35][36][37]. L'atteinte extra-ovarienne à l'origine d'un changement de stadification consiste le plus souvent en une cytologie péritonéale positive et/ ou dans l'existence d'implants microscopiques non invasifs sur l'épiploon ou les différentes biopsies péritonéales réalisées [6,35,36,38].…”

Section: Prise En Charge Standard : Intérêt D'une Stadification Complèteunclassified

Tumeur borderline de l’ovaire : comment préserver la fertilité ?

Koskas

Madelenat²,

Yazbeck

2009

Gynécologie Obstétrique & Fertilité

View full text Add to dashboard Cite

Surgical Staging of Ovarian Low Malignant Potential Tumors

Abstract: Routine pelvic and para-aortic lymph node dissection is not necessary in the majority of women with ovarian low malignant potential tumors.

Cited by 57 publications

References 20 publications

Lymph Node Involvement in Ovarian Serous Tumors of Low Malignant Potential (Borderline Tumors)

Lymph Node Involvement in Ovarian Serous Tumors of Low Malignant Potential (Borderline Tumors)

Mucinous borderline ovarian tumors: Analysis of 75 patients from a single center

Tumeur borderline de l’ovaire : comment préserver la fertilité ?

Contact Info

Product

Resources

About