Surveilans Penyalahgunaan Bahan Kimia Sintetis Deksametason Pada Jamu Pegal Linu Menggunakan Metode Near Infra Red dan Kemometrik

Abstract

Law Number 36 of 2009 regarding Health states that the community is given the widest opportunity to process, produce, distribute, develop, improve, and use traditional medicines that can be justified for their benefits and safety. The presence of medicinal chemicals added to traditional medicines (herbs) is not appropriate to the therapeutic dose, resulting in overdosing and causing side effects that can be harmful to the health of the consumers. One of the analytical methods to detect the presence of medicinal chemicals, especially dexamethasone, is the Near Infra Red and Chemometrics method. The research design used in this study was descriptive non-analytic. The population in this study is 28 herbal medicine shop that sells herbal sore-aches traditional medicines (jamu pegal linu) in Jember Regency using the Total Sampling technique. This study is using univariate analysis of frequency distribution. This research shows that there was no chemical content of dexametasone found in all herbal medicine samples in the analysis using the Near Infra Red method while in the Chemometric testing, it was found that one of the herbal samples (code J-C) contained 2% of dexamethasone. It is imperative to Socialize to the community the impact of using herbal medicine containing medicinal chemicals, and it also needs to be analyzed using the most sensitive methods.Keyword: Chemical Abuse, Dexamethasone, Sciatica Herbs, Near Infra Red, Chemometric Methods

Adulteration of Herbal Medicine and its Detection Methods

“…54 The use of HMs adulterated with dexamethasone was found to cause serious adverse effects, including nausea, fatigue, insomnia, anxiety, psychosis, exacerbation of schizophrenia, hypertension, and depression. 55,56 To enhance the action of weight gain products, cyproheptadine is also added to dexamethasone. 57…”

ANALISIS TEOFILIN DALAM JAMU SESAK NAPAS SEDIAAN SERBUK YANG BEREDAR DI KOTA BEKASI SECARA KLTp, SPEKTROFOTOMETRI UV/VIS DAN FTIR

“…Menurut BPOM, BKO diganti dengan bahan kimia yang mengandung obat seringkali ditambahkan ke dalam obat tradisional adalah fenilbutazon, antalgin, diklofenak sodium, piroksikam, parasetamol, prednison atau deksametason pada jamu pegal linu/encok/rematik; sibutramin hidroklorida pada jamu pelangsing; sildenafil sitrat pada jamu peningkat stamina atau obat kuat pria; glibenklamid pada jamu kencing manis/diabetes dan teofilin pada jamu sesak nafas atau asma. Bahan kimia yang ditambahkan ke dalam jamu bisa sangat berbahaya, karena efek samping yang ditimbulkan akibat penambahan dosis yang tidak terukur [6].…”

Simple Analytical Method on the Determination of Dexamethasone in Herbal Medicine

“…Dexamethasone is a glucocorticoid that acts as a very potent and long-acting anti-in ammatory agent with the mechanism of action of reducing the production of inammatory mediators such as suppressing the increase in neutrophils, reversing the increase in capillary permeability, and suppressing the immune response [5][6][7]. However, uncontrolled consumption of dexamethasone will cause some adverse e ects such as vomiting, malaise, insomnia, anxiety until psychosis, aggravation of schizophrenia [6], and moon face [8]. erefore, monitoring dexamethasone in herbal medicine is important.…”