Surveillance for InvasiveStreptococcus pneumoniaeDisease among Hospitalized Children in Bangladesh: Antimicrobial Susceptibility and Serotype Distribution

Abstract

High levels of nonsusceptibility to cotrimoxazole and susceptibility to penicillin suggest that penicillin may be a drug of choice for treatment of invasive pneumococcal disease. Although serotype distribution is diverse, with changes over time and differences between syndromes observed, implementation of use of the currently available 10- or 13-valent vaccines would have a substantial impact on pneumococcal disease in Bangladesh.

Prospective Surveillance Study of Invasive Pneumococcal Disease Among Urban Children in the Philippines

“…Other studies in asia have yielded mixed rates of antibiotic resistance, possibly influenced by local prescribing patterns. 5,10,13,[22][23][24][25] importantly, isolation of S. pneumoniae in this study may have been limited by the observed *Results from years 1 and 2 were annualized. The number of cases was the total of the number of cases captured during years 1 and 2.…”

Epidemiology, Diagnosis, and Antimicrobial Treatment of Acute Bacterial Meningitis

“…These data indicate the need for the development of immunization programs, especially in poor countries, to reduce morbidity and mortality (273). Surveillance studies of serotypes causing invasive pneumococcal disease in developing countries have also demonstrated that the current 7-valent pneumococcal vaccine would not cover all serotypes causing invasive disease and have suggested that wider coverage would be provided by the 10-valent or 13-valent pneumococcal conjugate vaccines (13,17,22,98,173,221,267,273,283,307,351,354). The introduction of these vaccines into these vulnerable populations is a crucial, but expensive, step to control this serious infection.…”

Changing Trends in Antimicrobial Resistance and Serotypes of Streptococcus pneumoniae Isolates in Asian Countries: an Asian Network for Surveillance of Resistant Pathogens (ANSORP) Study

“…According to recent data from the United States in 2007, 93.2% of penicillin-nonsusceptible isolates which caused invasive diseases showed non-PCV7 serotypes, and serotype 19A accounted for 53.2% of these penicillin-nonsusceptible isolates (5). However, since the introduction of PCV7 to Asian countries, the epidemiology of S. pneumoniae in Asian countries has not been well investigated (21,26). Therefore, the ANSORP Study Group performed a prospective, multinational, hospitalbased surveillance study in patients with pneumococcal infections in 11 Asian countries during 2008 to 2009 to investigate the current status of antimicrobial resistance and serotype distribution in S. pneumoniae after the introduction of PCV7.…”