Surveillance of meningococcal infections in Belgium

Looveren, M. Van; Carion, FranÃ§oise; Vandamme, Peter; Goossens, Herman

doi:10.1111/j.1469-0691.1998.tb00675.x

Cited by 10 publications

(11 citation statements)

References 22 publications

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“…7, B 4p1.3,6, B 15p1.12,13 and B 1p1.4 strains. However, this is not surprising, as it has been documented previously that B 4p1.4 strains can be closely related genetically to strains of other diverse serological phenotypes (Van Looveren et al, 1998, 2001. Therefore, it could be concluded that serotype 4 could be important for inclusion in RT5, although other strains of serotype 4, three B 4p1.15 strains and two C 4p1.10 strains, yielded a different RT, RT15.…”

Section: Discussionsupporting

confidence: 51%

Multilocus restriction typing: a tool for Neisseria meningitidis strain discrimination

Bennett

Cafferkey

2003

Journal of Medical Microbiology

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Invasive disease-associated strains of Neisseria meningitidis were analysed by multilocus restriction typing (MLRT), which involves the restriction fragment-length polymorphism analysis of PCR products generated from the seven loci of housekeeping genes used in MLST. Several different restriction patterns (alleles) were observed for each of the seven loci examined. Greater allelic variation was observed with the fumC and pgm loci than with the abcZ and adk loci, suggesting that the latter were more conserved. The alleles at each of the seven loci were combined to give an allelic profile or restriction type (RT). A good correlation between RT and serogroup, serotype and serosubtype was observed, as all C 2ap1.2,5 strains were contained in a single RT, as were all but one strain of B 4p1.4. In this study, MLRT proved to be an efficient, effective and relatively inexpensive method for N. meningitidis strain characterization.

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Section: Discussionsupporting

confidence: 51%

Multilocus restriction typing: a tool for Neisseria meningitidis strain discrimination

Bennett

Cafferkey

2003

Journal of Medical Microbiology

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“…In Spain the incidence increased from 0.4% in 198512 to 67% in 1996 13. In the United Kingdom the incidence rose to 11% in 199514; in Belgium 6% of meningococcal isolates showed reduced susceptibility to penicillin in 1998 15. From the data, it seems that the prevalence of resistance is low in other parts of the world; in the Netherlands it is still below 2% 16…”

Section: Neisseria Meningitidismentioning

confidence: 96%

“…Rifampicin resistance is rare, and resistance to fluoroquinolone drugs has not yet been reported. 14 15 Nevertheless, evidence of the development of resistance to penicillin and to other antibiotics in N meningitidis is mounting.…”

Section: Neisseria Meningitidismentioning

confidence: 99%

Community acquired infections and bacterial resistance

Goossens

Sprenger

1998

BMJ

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“…Serogroup B has always been the main cause of meningococcal disease in Belgium (24,25), but in the late 1990s the incidence of serogroup C disease increased considerably and peaked in 2001 (10). The greatest burden of serogroup C meningococcal disease was observed in young children and in teenagers.…”

mentioning

confidence: 99%

Evolutionary Changes in Antimicrobial Resistance of Invasive Neisseria meningitidis Isolates in Belgium from 2000 to 2010: Increasing Prevalence of Penicillin Nonsusceptibility

Bertrand

Carion

Wintjens

et al. 2012

Antimicrob Agents Chemother

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bThis study was conducted to evaluate the evolution of the antimicrobial susceptibility of Neisseria meningitidis causing invasive diseases in Belgium in the period of January 2000 to December 2010. A total of 1,933 cases of N. meningitidis from invasive infections were analyzed by antimicrobial susceptibility testing at the Belgian Meningococcal Reference Centre. The majority of strains were susceptible to antibiotics that are currently used for the treatment and prophylaxis of meningococcal disease, but the prevalence of clinical isolates with reduced susceptibility to penicillin increased over the years. The phenotyping, genotyping, and determination of MICs of penicillin G were performed. The systematic shift of the curves toward higher penicillin MICs in the susceptible population indicated that this population became less sensitive to penicillin in this period. A 402-bp DNA fragment in the 3= end of penA was sequenced for the 296 nonsusceptible meningococcal strains isolated between 2000 and 2010 to examine the genetic diversity and evolution of their penA gene. In conclusion, the data obtained in our study support the statement that the position of penicillin G as a first choice in the treatment of invasive meningococcal diseases in Belgium should be reexamined. Despite an important number of isolates displaying a reduced susceptibility to penicillin, at present the expandedspectrum cephalosporins, such as ceftriaxone, are not affected. The follow-up of the evolutionary changes in antimicrobial resistance has also proved to be essential for the recommendation of an appropriate antimicrobial treatment for invasive meningococcal diseases.

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Surveillance of meningococcal infections in Belgium

Cited by 10 publications

References 22 publications

Multilocus restriction typing: a tool for Neisseria meningitidis strain discrimination

Multilocus restriction typing: a tool for Neisseria meningitidis strain discrimination

Community acquired infections and bacterial resistance

Evolutionary Changes in Antimicrobial Resistance of Invasive Neisseria meningitidis Isolates in Belgium from 2000 to 2010: Increasing Prevalence of Penicillin Nonsusceptibility

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