An early naturalist described lakes as "jewels" across the landscape and indeed they were…at the end of the nineteenth century. As we settled the country and began to utilize the lake resource for our needs, things changed. Additionally, our needs for water brought about the construction of impoundments from ice ponds to small stock ponds up to mainstem impoundments along our major rivers. The lake resource in the United States now includes natural lakes in our northern tier of states, unique physiographic regions such as Florida and the Sand Hills of Nebraska, and the mountainous regions, and impoundments scattered across the entire landscape. In this chapter, we will describe efforts by an unique partnership between the individual states and tribal nations of the USA and the US Environmental Protection Agency to monitor and assess these systems. These efforts go beyond single water quality (chemistry) issues and include assessments targeting the goal of the Clean Water Act, namely, restoring, maintaining, and protecting the chemical, physical, and biological integrity of the nation's lakes and reservoirs.