2005
DOI: 10.1016/j.jcv.2004.04.002
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Survey of acyclovir-resistant herpes simplex virus in the Netherlands: prevalence and characterization

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Cited by 219 publications
(159 citation statements)
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“…In a setting of antiviral prophylaxis, HSV-1 resistance was demonstrated by viral culture in 27% of patients with HSV. 13 In other studies, a prevalence of resistance of 14% was found using a colorimetric yield reduction assay 14 and of 18% using another colorimetric assay. 12 The retrospective analysis of resistance in our study hampers addressing the clinical significance of the infections with resistant HSV-1.…”
Section: Discussionmentioning
confidence: 90%
“…In a setting of antiviral prophylaxis, HSV-1 resistance was demonstrated by viral culture in 27% of patients with HSV. 13 In other studies, a prevalence of resistance of 14% was found using a colorimetric yield reduction assay 14 and of 18% using another colorimetric assay. 12 The retrospective analysis of resistance in our study hampers addressing the clinical significance of the infections with resistant HSV-1.…”
Section: Discussionmentioning
confidence: 90%
“…A serine to asparagine change was detected at position 180 of the TK protein of HSV-1 strain 5123376433, but the role of this mutation in drug resistance is unknown. Strain C74106 harbored an arginine to histidine change at position 222 of the TK enzyme that was reported to induce resistance to ACV (20). HSV-1 strain C114093 contained the change of an arginine by a stop codon at position 281 of the TK that was associated with resistance to ACV (21).…”
Section: Cellsmentioning
confidence: 99%
“…A study conducted in the Netherlands analyzed 542 HSV isolates and found ACV resistance in only 0.27% of immunocompetent patients. In contrast, the prevalence of ACV-resistant virus in immunocompromised patients was 7%, and the highest frequency of resistance (14.3%) was observed among patients after hematopoietic stem cell transplantation (7). ACV resistance frequencies of even more than 25% have been reported for patients in the allogeneic stem cell or bone marrow transplantation setting (8,9).…”
mentioning
confidence: 94%