“…Moreover, osteoinductive biomaterials should be able to recruit progenitor cells (MCS) to the grafted site, induce the formation of osteoblasts by differentiating progenitor cells (MCS) in mature cells and eventually regenerate ectopic bone where there is no extraskeletal structure [ 36 ]. The prevalence of implant failure and wear has been related to the presence of inflammation and infections as a result of oral diseases, such as peri-implant and oral flora disorders/dysbiosis [ 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ]. The biophysical and biochemical properties of biomaterials could influence the cellular responses, including the macro-topography, pore geometry and stiffness, surface chemistry, rate of degradation and presence of biomolecules, influence proliferation and differentiation to eventually give tissue regeneration [ 48 , 49 ].…”