Survival Rates of Lung Cancer According to Histological Type

Campobasso, O; Invernizzi, B; Musso, M; Berrino, Franco

doi:10.1038/bjc.1974.63

Cited by 29 publications

(9 citation statements)

References 16 publications

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“…In effect, the data demonstrate the need for only three symptom status categories: I (Zubrod 0-I), I1 (2), and I11 (3)(4). The data did not suggest that information was lost by employing the simpler Zubrod system.…”

Section: Discussio~mentioning

confidence: 75%

Survival with inoperable lung cancer.An integration of prognostic variables based on simple clinical criteria

Lanzotti

Thomas

Boyle

et al. 1977

Cancer

158

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The objectives are to identify and integrate through regression analysis those fundamental clinical variables predicting survival of patients with inoperable lung cancer managed in a modern setting. Median survival time from first treatment in 129 patients with limited disease and 187 patients with extensive disease was 36 and 14 weeks, respectively. Within the proposed survival model for limited disease, weight loss was the major prognosticator followed by symptom status, supraclavicular metastases, and age. Within extensive disease, symptom status and age were dominant variables followed by weight loss and metastases to liver, opposite hemithorax, brain, and bone. Survival by cell type was similar within the limited and extensive disease groups. The data identify the essential factors which must be controlled or accounted for in studies analyzing survival as a dependent variable.

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Section: Discussio~mentioning

confidence: 75%

Survival with inoperable lung cancer.An integration of prognostic variables based on simple clinical criteria

Lanzotti

Thomas

Boyle

et al. 1977

Cancer

158

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“…The lung cancer survival rate shows a difference by histological type, with NSCLC having a better prognosis compared to SCLC [ 19 ]. However, the staging of a tumor is the strongest determinant factor of lung cancer survival.…”

Section: Discussionmentioning

confidence: 99%

An overview of mortality & predictors of small-cell and non-small cell lung cancer among Saudi patients

Alghamdi

Alshehri

Farhat³

2017

JEGH

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Lung cancer ranks as the top cancer worldwide in terms of incidence and constitutes a major health problem. About 90% of lung cancer cases are diagnosed at advance stage where treatment is not available. Despite evidence that lung cancer screening improves survival, guidelines for lung cancer screening are still a subject for debate. In Saudi Arabia, only 14% of lung cancers are diagnosed at early stage and researches on survival and its predictors are lacking. This overview analysis was conducted on predictors of lung cancer mortality according to the two major cancer types, small-cell lung cancers (SCLCs) and non-small cell lung cancers (NSCLCs) in Saudi Arabia. A secondary data analysis was performed on small-cell lung cancers (SCLCs) and Non-small cell lung cancers (NSCLCs) registered in the Saudi Cancer Registry (SCR) for the period 2009-2013 to estimate predictors of mortality for both lung cancer types. A total of 404 cases (197 SCLC and 207 NSCLC) were included in the analysis, all Saudi nationals. A total of 213 (52.75%) deaths occurred among lung cancer patients, 108 (54.82%) among SCLCs and 105 (50.72%) among NCSLCs. Three quarter of patients are diagnosis with advance stage for both SCLC & NSCLC. Univariate analysis revealed higher mean age at diagnosis in dead patients compared to alive patients for SCLCs (p=0.04); but not NSCLCs, a lower mortality for NSCLCs diagnosed in 2013 (p=0.025) and a significant difference in stage of tumor (p=0.006) and (p=0.035) for both SCLC and NSCLC respectively. In multiple logistic regression, stage of tumor was a strong predictor of mortality, where distant metastasis increased morality by 6-fold (OR=5.87, 95% CI: 2.01 - 17.19) in SCLC and by 3-fold (OR=3.29, 95% CI: 1.22 - 8.85) in NSCLC, compared to localized tumors. Those with NSCLC who were diagnosed in 2013 were less likely to die by 64% compared to NSCLC diagnosed in 2009 (OR=0.36, 95% CI: 0.14 - 0.93). Age, sex, topography and laterality were not associated with mortality for both types of lung cancer. We observed that the stage of the tumor is the strongest predictor of mortality for both SCLCs and NSCLs. This confirms the impact of diagnostic stage on survival. However, establishing Saudi-specific lung cancer screening guidelines will require further research on the benefits and harms of screening modalities in the Saudi population.

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“…However, routine use of these techniques has, so far, been limited and the light microscopic pattern still remains the principal criterion for pathological diagnosis and therapy planning (Sobin, 1991). This was well recognized when, in 1967, a WHO classification (Kreyberg et al, 1967) was suggested in order to distinguish morphological categories of tumours corresponding to different types of clinical behaviour (Kern et al, 1968;Campobasso et al, 1974). This classification was updated in 1981 (WHO, 1981) because of the need for a better reproducibility of typing, using stricter criteria.…”

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confidence: 99%

“…The same material, classified according to the 1967 WHO criteria under the direction of one of us (O.C. ), had been used in previous studies on clinical-pathological correlations in lung cancer (Campobasso et al, 1974(Campobasso et al, ,1989.…”

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confidence: 99%

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The value of the 1981 who histological classification in inter‐observer reproducibility and changing pattern of lung cancer

Campobasso

Andrion

Ribotta

et al. 1993

Intl Journal of Cancer

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A series of 722 lung carcinomas, surgically resected and typed some years ago according to the 1967 WHO classification, was independently reviewed by 2 observers in order to test the reproducibility of histopathological typing when using the criteria of the 1981 WHO classification. Typing was fully agreed upon in 87% of cases. Agreement was very high for squamous-cell, small-cell and adeno-carcinomas (kappa = 0.87, 0.89 and 0.85, respectively) while adenosquamous (kappa = 0.56) and large-cell (kappa = 0.71) carcinomas were more controversial categories. A consensus diagnosis was formulated for lesions with discrepant diagnoses. When comparing the final typing to the previous typing based on the 1967 WHO classification, squamous- and large-cell carcinomas were reduced respectively by 22% and 33% and adenocarcinomas increased by 94% of the original number. The 1981 "adenosquamous carcinoma" category included 2.8% of the tumours, while the corresponding 1967 category "combined epidermoid and adenocarcinoma" was empty. These changes must be taken into account when considering epidemiological studies, especially those aiming at evaluation of the secular trends of lung cancer by cell type.

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Survival Rates of Lung Cancer According to Histological Type

Cited by 29 publications

References 16 publications

Survival with inoperable lung cancer.An integration of prognostic variables based on simple clinical criteria

Survival with inoperable lung cancer.An integration of prognostic variables based on simple clinical criteria

An overview of mortality & predictors of small-cell and non-small cell lung cancer among Saudi patients

The value of the 1981 who histological classification in inter‐observer reproducibility and changing pattern of lung cancer

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