Survivin and laryngeal carcinoma prognosis: nuclear localization and expression of splice variants

Marioni, Gino; Agostini, Marco; Bedin, Chiara; Blandamura, Stella; Stellini, Edoardo; Favero, Gian Antonio; Lionello, Marco; Giacomelli, Luciano; Burti, Silvia; D’Angelo, Edoardo; Nitti, Donato; Staffieri, Alberto; Filippis, Cosimo de

doi:10.1111/j.1365-2559.2012.04217.x

Cited by 20 publications

(19 citation statements)

References 33 publications

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“…Several previous studies have described survivin expression in laryngeal carcinoma, but contradictory results have been reported. In our series, survivin nuclear reaction predominated, in agreement with several previous studies [27,28,33]. Meanwhile, other researchers found that survivin was mainly distributed in LSCC cytoplasm [23,38].…”

Section: Discussionsupporting

confidence: 93%

Stem cell markers OCT4 and nestin in laryngeal squamous cell carcinoma and their relation to survivin expression

Deeb

Abdelzaher

2014

Pathology - Research and Practice

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Section: Discussionsupporting

confidence: 93%

Stem cell markers OCT4 and nestin in laryngeal squamous cell carcinoma and their relation to survivin expression

Deeb

Abdelzaher

2014

Pathology - Research and Practice

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“…Literature data suggests higher expression of survivin (nuclear or cytoplasmic or both), as an apoptotic marker which correlates significantly with tumor grade, stage, and patient outcome including recurrence rate, and disease-free survival rate [12,[36][37][38]. Current reports in these research areas are inconsistent and propose opposing conclusions regarding the significance and prognostic value of nuclear and cytoplasmic immunoexpression of survivin [30].…”

Section: Discussionmentioning

confidence: 81%

Immunohistochemical study on survivin in sinonasal tumors and its relationship with the immunoexpression of Ki67 and Bcl-2

Stasikowska-Kanicka

Wągrowska-Danilewicz

Danilewicz

2013

Folia Histochem Cytobiol.

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Abstract:The immunoexpression of the inhibitor of apoptosis protein survivin has been shown to be a significant prognostic factor in various human cancers. Immunohistochemical method was used to examine the expression of survivin, Ki67 and Bcl-2 in 20 cases of sinonasal inverted papillomas (IPs), 12 cases of sinonasal squamous cell carcinoma (SNCs) and 19 cases of nasal chronic sinusitis as a control. Nuclear immunostaining for survivin was observed in 14 of 20 (70%) cases of sinonasal IPs and 10 of 12 (83.4%) cases of SNCs. Apart from nuclear, also weak cytoplasmic immunoexpression of survivin was detected in 2 of 20 cases (10%) of sinonasal IP and moderate intense staining in 9 of 12 cases (75%) of SNC. There was no immunostaining for survivin in 19 control cases. The immunoexpression of survivin, Ki67 and Bcl-2 was significantly higher in SNCs than in sinonasal IPs and control group. Moreover, nuclear survivin and Ki67 antigen immunoexpression were significantly higher in sinonasal IPs group as compared to control group. There were statistically significant positive correlations between nuclear (but not cytoplasmic) immunoexpression of survivin and Ki67 antigen, as well as Bcl-2 oncoprotein in both tested tumors. In conclusion, our findings suggest that survivin, Ki67 and Bcl-2 may be involved in sinonasal tumorigenesis.

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“…The six known splice variants of the survivin gene transcript have recently been found to localise in different subcellular components, where they have distinct functions 1 2. Survivin is transiently expressed during embryonic development, then barely detectable in normal, differentiated adult cells and tissues, apart from certain tissues such as the thymus and placenta 2.…”

Section: Introductionmentioning

confidence: 99%

“…In the case of laryngeal squamous cell carcinoma (LSCC), the nuclear expression of survivin appears to influence the tumour's aggressiveness, and wild-type survivin is the most frequently detected splice variant 1. The novel main aim of this study was to conduct a preliminary investigation into the possible role of survivin expression in LSCC neoangiogenesis, as determined from endoglin-assessed MVD.…”

Section: Introductionmentioning

confidence: 99%

Nuclear survivin expression correlates with endoglin-assessed microvascularisation in laryngeal carcinoma

et al. 2017

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Survivin-targeting strategies to enhance tumour cell response to apoptosis and inhibit tumour growth should receive more attention with a view to developing agents for use in multimodality advanced LSCC treatment, or combined with conventional chemotherapy. Given the present preliminary evidence in LSCC, survivin targeting should also be further investigated for anti-angiogenic purposes, to reduce tumour blood flow and induce cancer necrosis.

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Survivin and laryngeal carcinoma prognosis: nuclear localization and expression of splice variants

Abstract: Nuclear expression of survivin appears to influence LSCC aggressiveness, a higher nuclear survivin expression correlating with a higher recurrence rate and a shorter DFS. Wild-type survivin was the most frequently detected splice variant in LSCC tissues.

Cited by 20 publications

References 33 publications

Stem cell markers OCT4 and nestin in laryngeal squamous cell carcinoma and their relation to survivin expression

Stem cell markers OCT4 and nestin in laryngeal squamous cell carcinoma and their relation to survivin expression

Immunohistochemical study on survivin in sinonasal tumors and its relationship with the immunoexpression of Ki67 and Bcl-2

Nuclear survivin expression correlates with endoglin-assessed microvascularisation in laryngeal carcinoma

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