Susceptibility breakpoint for cefquinome against Escherichia coli and Staphylococcus aureus from pigs

Zhang, Huilin; Zhao, Yiyang; Zhou, Zichong; Ding, Huanzhong

doi:10.1016/s2095-3119(20)63572-9

Cited by 2 publications

(2 citation statements)

References 38 publications

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“…ruckeri isolated from various fish was 0.12 μg/ml (Huang et al, 2014). In this study, %T > MIC was calculated using the hypothetical MIC values (≤2 μg/ml) that were determined based on susceptibility breakpoint (2 μg/ml, Zhang et al, 2021). In this study, the T > MIC value following IP and IV administration at 10 mg/kg dose of cefquinome in the rainbow trout was above 40% for bacteria, with MIC values of ≤2 μg/ml at 72 and 96 h intervals, respectively, but cefquinome for oral route never reached the MIC values of ≤2 μg/ml.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of cefquinome in rainbow trout (Oncorhynchus mykiss) after intravascular, intraperitoneal, and oral administrations

Çorum

Terzi̇

et al. 2022

Vet Pharm & Therapeutics

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This study aimed to determine the pharmacokinetics and bioavailability of cefquinome in rainbow trout (Oncorhynchus mykiss) following intravascular (IV), intraperitoneal (IP), and oral (PO) administrations at 14 ± 1°C. In this study, three hundred and six clinically healthy rainbow trout (110-140 g) were used. The fish received single IV, IP, and PO injections of cefquinome at 10 mg/kg dose. The plasma concentrations of cefquinome were measured using HPLC-UV and were evaluated using non-compartmental analysis. Cefquinome was measured up to 96 h for PO route and 144 h for IV and IP routes in plasma. Following IV administration, t 1/2ʎz , Cl T , and V dss were 18.85 h, 0.037 L/h/ kg, and 0.84 L/kg, respectively. The C max of IP and PO routes was 9.75 and 1.64 μg/ ml, respectively. The bioavailability following IP and PO administrations was 59.46% and 12.33%, respectively. Cefquinome at 10 mg/kg dose may maintain T > MIC above 40% at 72 and 96 h intervals, respectively, following the IP and IV routes for bacteria with MIC values of ≤2 μg/ml and at 24 h intervals following the PO route for bacteria with MIC value of ≤0.75 μg/ml. However, further studies are needed to determine in vitro and in vivo antibacterial efficacy and multiple dosage regimens of cefquinome against pathogens isolated from rainbow trout.

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of cefquinome in rainbow trout (Oncorhynchus mykiss) after intravascular, intraperitoneal, and oral administrations

Çorum

Terzi̇

et al. 2022

Vet Pharm & Therapeutics

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“…Finally, an MIC of 41.8 µg•mL −1 was achieved for tri-assembly against E. coli, which was significantly promoted compared to EuW10 and the bi-assemblies. In addition, among the reported antibacteria materials (Table S1) [29][30][31][32][33][34], the efficiency of the constructed tri-assembly is comparabl (p < 0.001).…”

Section: Enhanced Antibacterial Effects Of the Bi-and Tri-assemblymentioning

confidence: 96%

Adaptive Responses of a Peroxidase-like Polyoxometalate-Based Tri-Assembly to Bacterial Microenvironment (BME) Significantly Improved the Anti-Bacterial Effects

Zhang

Liu

Kong

et al. 2023

IJMS

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The present study presents the tertiary assembly of a POM, peptide, and biogenic amine, which is a concept to construct new hybrid bio-inorganic materials for antibacterial applications and will help to promote the development of antivirus agents in the future. To achieve this, a Eu-containing polyoxometalate (EuW10) was first co-assembled with a biogenic amine of spermine (Spm), which improved both the luminescence and antibacterial effect of EuW10. Further introduction of a basic peptide from HPV E6, GL-22, induced more extensive enhancements, both of them being attributed to the cooperation and synergistic effects between the constituents, particularly the adaptive responses of assembly to the bacterial microenvironment (BME). Further intrinsic mechanism investigations revealed in detail that the encapsulation of EuW10 in Spm and further GL-22 enhanced the uptake abilities of EuW10 in bacteria, which further improved the ROS generation in BME via the abundant H2O2 involved there and significantly promoted the antibacterial effects.

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Susceptibility breakpoint for cefquinome against Escherichia coli and Staphylococcus aureus from pigs

Cited by 2 publications

References 38 publications

Pharmacokinetics of cefquinome in rainbow trout (Oncorhynchus mykiss) after intravascular, intraperitoneal, and oral administrations

Pharmacokinetics of cefquinome in rainbow trout (Oncorhynchus mykiss) after intravascular, intraperitoneal, and oral administrations

Adaptive Responses of a Peroxidase-like Polyoxometalate-Based Tri-Assembly to Bacterial Microenvironment (BME) Significantly Improved the Anti-Bacterial Effects

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