The challenge of Nigeria's food insecurity in the era of the Covid-19 pandemic, insecurity, climate change, population growth, food wastage, etc., is a demanding task. This study addresses Nigeria's food insecurity challenges by adopting agriculture 4.0 and commercial farming. Using data from six digital libraries, the Nigerian Bureau of Statistics, and other internet sources, we conducted a Systematic Literature Review (SLR using PRISMA) on Nigeria's agriculture, food security, and agriculture 4.0. Our results show Nigeria's current agricultural state, threats to food security, and modern digital agriculture technologies. We adapted our SLR findings to develop an implementation framework for agriculture 4.0 in solving Nigeria's food insecurity challenge in the post-Covid-19 era. Our proposed framework integrates precision agriculture in Nigeria's food production and the necessary enabling digital technologies in the agri-food supply chain. We analyzed the critical implementation considerations during each agri-food supply chain stage of farming inputs, farming scale, farming approach, farming operation, food processing, food preservation/storage, distribution/logistics, and the final consumers. This study will help researchers, investors, and the government address food security in Nigeria. The implementation of agriculture 4.0 will substantially contribute to SDG 2 (zero hunger), SDG 3 (good health and well-being), and SDG 8 (decent work and economic growth) of #Envision 2030 of the United Nations, for the benefit of Nigeria, Africa, and the entire world.INDEX TERMS Agriculture 4.0, agri-food 4.0, food security, Sustainability, SDG goal 2, implementation framework, supply chain.