The paper analyzes three key indicators of economic growth and life quality from the National Development Goals of the Russian Federation. The following equivalents of these indicators were identified to form regions into clusters and highlight the main trends in their development: the growth rate of gross regional product (GRP), life expectancy, and poverty level. We studied the nationwide data based on the indicators, analyzed the distribution of regions, and carried out a cluster analysis according to 2017-2019 data. Our results suggest expanding the list of the Russian Federation subjects that require additional support in their development. More than one-third of the regions of the Russian Federation have been developing at a rate of less than one percent per year in the last three years. Considering the consequences of the pandemic, it can lead to serious problems in achieving the declared growth rates. Plans to increase life expectancy have already been adjusted. Considering the little-studied consequences of coronavirus infection, additional measures in the medical field will be required. The level of poverty of the population also demonstrates a significant degree of differentiation of the Russian Federation regions.