Research about indoor comfort in future years will increasingly be guided by the pressing need for decarbonizing the built environment due to climate change. Health, efficiency, and satisfaction of work and the feeling of comfort are largely determined by the interior criteria. The sustainable indoor environment is a result of complex factors: air conditioning (ventilation), indoor temperature, heating methods, lighting, and acoustic. This chapter explores and analyzes climatic, cultural, and behavioral factors that play an important role and have an influence on technology for an indoor regenerative environment. This chapter is based on an explorative literature review and reflects indoor environmental quality, users’ expectations, and users’ behavior from the perspective of different scientific disciplines. Current standards are based on a rational approach to thermal comfort, and indicators are determined on the measured subjects’ reactions during stabilized conditions in climatic chambers. It is concluded from these results that people in different environmental conditions react similarly to everyday life. Nevertheless, survey results suggest that achieving the optimal level of the indoor environment is possible when climatic, cultural, and social context is taken into account.