Sustained delivery of atenolol drug using gum dammar crosslinked polyacrylamide and zirconium based biodegradable hydrogel composites

Sharma, Pooja; Mittal, Hemant; Jindal, Rajeev; Jindal, Dhruvi; Alhassan, Saeed M.

doi:10.1016/j.colsurfa.2018.11.039

Cited by 43 publications

(14 citation statements)

References 55 publications

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“…A linear regression of log Q versus log t was performed for the three formulations to find Km and n value, which gives an indication about the release mechanism. A Fickian diffusion mechanism is indicated when n value ≤ 0.5, A n anomalous mechanism (the release is controlled by both diffusion and relaxation of the polymeric chain) when 0.5 ˂ n value ˂ 1.0, case 2 transport (release is controlled by relaxation of the polymeric chain) when n value = 1 and super case 2 transport (the release is controlled by both diffusion and relaxation of the polymeric chain) when n value>1.0 [41][42][43]. The estimated n value was between 0.5 and 1.0 for the three prepared formulations, which indicates an anomalous release mechanism.…”

Section: In Vitro Drug Release Studiesmentioning

confidence: 99%

Drug Release Control and Enhancement Using Carriers With Different Concentrations of Capmul® MCM C8

Bayan

2021

Int J App Pharm

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Objective: The main aim of this study was to design a drug carrier capable to control and enhance the release of poorly water soluble drugs. Methods: Three polymeric formulations, based on poly (2-hydroxyethyl methacrylate) and loaded with different Capmul® MCM C8 concentrations (0, 10 and 20 % w/w), were prepared. Felodipine, which is a poorly soluble substance, was selected as a model drug. The effect of Capmul® MCM C8 on swelling behavior and in vitro release profile of the prepared polymer was investigated in PBS. Results: The swelling profiles of allformulationswere statistically similar, which indicated the non-significant effect of added Capmul® MCM C8 on polymer's swelling behavior. All formulations showed a delayed drug release. Formulation-F3, which is loaded with 20% w/wCapmul® MCM C8 displayed a significant higher release compared to the other formulations. Conclusion: Capmul® MCM products, which are widely used in food industries, can be used to improve the oral delivery of poorly soluble substances. The optimized formulation exhibited the ability to control and enhance the release of the model drug.

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Section: In Vitro Drug Release Studiesmentioning

confidence: 99%

Drug Release Control and Enhancement Using Carriers With Different Concentrations of Capmul® MCM C8

Bayan

2021

Int J App Pharm

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“…So, polyacrylamide polymers are widely studied in controlled‐release systems, as evidenced by the considerable number of publications in scientific journals 12–14,28–33 . So, in paper 28 an electroresponsive drug delivery system was developed using poly(acrylamide‐grafted‐xanthan gum) (PAAm‐g‐XG) hydrogel for transdermal delivery of ketoprofen.…”

Section: Introductionmentioning

confidence: 99%

“…The PAAm‐g‐XG hydrogel could be useful as transdermal drug delivery systems actuated by an electric signal to provide on‐demand release of drugs. Sustained delivery of atenolol drug using Gum dammar (Gd), crosslinked polyacrylamide and zirconium based biodegradable hydrogel composites was described in 29 . In order to utilize drugs to maximum and to minimize their adverse effects on human health the authors have used crosslinked graft co‐polymer of natural gum polysaccharide (Gd) and acrylamide, that is, Gd‐cl‐poly(AAm) and its organo‐inorganic hydrogel composite with zirconium (i.e.…”

Section: Introductionmentioning

confidence: 99%

Polymer matrices on the basis of polyacrylamide and β‐cyclodextrin‐containing pseudorotaxane for prolonged drug release: Synthesis and properties

Sinelnikov

Orel

Kobrina

et al. 2021

J of Applied Polymer Sci

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Polymer cross‐linked matrices based on polyacrylamide (PAA) and β‐cyclodextrin‐pseudorotaxane have been designed. The structure and properties of the objects synthesized were confirmed and studied by a series of methods, involving ultraviolet‐, Fourier transform infrared‐spectroscopy, thermal mass spectrometry, DSC, X‐ray diffraction analysis (WAXS and SAXS). Desorption kinetics (especially significant slowing of desorption process) of some drugs, like metoprolol succinate and loratadine from obtained polymer matrices is shown to be optimal with 10 wt% β‐CD‐pseudorotaxane in their structure.

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“…Thus, ref. [ 37 ] looks into the continuous administration of the drug atenolol, made of Dammar gum interlaced with hydrogel biodegradable composites based on polyacrylamide and zirconium. The interlacing process was synthesized successfully, obtaining improved properties for the polyacrylamide Dammar gum, which is explained by the presence of an inorganic component in the zirconium mixture.…”

Section: Introductionmentioning

confidence: 99%

A Study of Some Mechanical Properties of Composite Materials with a Dammar-Based Hybrid Matrix and Reinforced by Waste Paper

Stănescu

Bolcu

2020

Polymers

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When obtaining environment-friendly hybrid resins made of a blend of Dammar natural resin, in a prevailing volume ratio, with epoxy resin, it is challenging to find alternatives for synthetic resins. Composite materials reinforced with waste paper and matrix made of epoxy resin or hybrid resin with a volume ratio of 60%, 70% and 80% Dammar were studied. All samples obtained have been submitted to tensile tests and Scanning Electron Microscopy (SEM) analysis. The tensile response, tensile strength, modulus of elasticity, elongation at break and the analysis of the fracture surface were determined. The damping properties of vibrations of bars in hybrid resins and in the composite materials under study were also examined. The mechanical properties of the four types of resins and of the composite materials were compared. The chemical composition for a hybrid resin specimen were obtained using the Fourier Transformed Infrared Spectroscopy (FTIR) and Energy, Dispersive X-ray Spectrometry (EDS) analyzes.

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Sustained delivery of atenolol drug using gum dammar crosslinked polyacrylamide and zirconium based biodegradable hydrogel composites

Cited by 43 publications

References 55 publications

Drug Release Control and Enhancement Using Carriers With Different Concentrations of Capmul® MCM C8

Drug Release Control and Enhancement Using Carriers With Different Concentrations of Capmul® MCM C8

Polymer matrices on the basis of polyacrylamide and β‐cyclodextrin‐containing pseudorotaxane for prolonged drug release: Synthesis and properties

A Study of Some Mechanical Properties of Composite Materials with a Dammar-Based Hybrid Matrix and Reinforced by Waste Paper

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