Sustained dual release of placental growth factor-2 and bone morphogenic protein-2 from heparin-based nanocomplexes for direct osteogenesis

Liu, Yun; Deng, Lei; Sun, Haipeng; Xu, Jinkai; Li, Yiming; Xie, Xin; Zhang, Liming; Deng, Feilong

doi:10.2147/ijn.s100156

Cited by 33 publications

(18 citation statements)

References 55 publications

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“…For this reason, recent focus has been on incorporating a combination of several GFs within biomaterials. For example, chitosan nanocomplexes encapsulating PlGF-2 and BMP-2, GFs that stimulate angiogenesis and osteogenesis, respectively, indicated that the dual delivery of PlGF-2 and BMP-2 has a greater potential to regenerate bone tissue compared with the delivery of either GF alone [63]. In another approach, a dual GF delivery system was designed composed of PLGA nanoparticles and alginate microcapsules encapsulating BMP-2 and VEGF, respectively.…”

Section: Controlled Release Of Biomolecules From Biomaterialsmentioning

confidence: 99%

Enhancing regenerative approaches with nanoparticles

Rijt

Habibović

2017

J. R. Soc. Interface.

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In this review, we discuss recent developments in the field of nanoparticles and their use in tissue regeneration approaches. Owing to their unique chemical properties and flexibility in design, nanoparticles can be used as drug delivery systems, to create novel features within materials or as bioimaging agents, or indeed these properties can be combined to create smart multifunctional structures. This review aims to provide an overview of this research field where the focus will be on nanoparticle-based strategies to stimulate bone regeneration; however, the same principles can be applied for other tissue and organ regeneration strategies. In the first section, nanoparticlebased methods for the delivery of drugs, growth factors and genetic material to promote tissue regeneration are discussed. The second section deals with the addition of nanoparticles to materials to create nanocomposites. Such materials can improve several material properties, including mechanical stability, biocompatibility and biological activity. The third section will deal with the emergence of a relatively new field of research using nanoparticles in advanced cell imaging and stem cell tracking approaches. As the development of nanoparticles continues, incorporation of this technology in the field of regenerative medicine will ultimately lead to new tools that can diagnose, track and stimulate the growth of new tissues and organs.

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Section: Controlled Release Of Biomolecules From Biomaterialsmentioning

confidence: 99%

Enhancing regenerative approaches with nanoparticles

Rijt

Habibović

2017

J. R. Soc. Interface.

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“…This new nanocomplex shows good potential in the bone regeneration process. 91 An outline for preparing the heparin-based nanocomplexes supported with PlGF is shown in Figure 8.…”

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confidence: 99%

A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine

Jahangirian

Lemraski

Webster

et al. 2017

IJN

449

216

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This review discusses the impact of green and environmentally safe chemistry on the field of nanotechnology-driven drug delivery in a new field termed “green nanomedicine”. Studies have shown that among many examples of green nanotechnology-driven drug delivery systems, those receiving the greatest amount of attention include nanometal particles, polymers, and biological materials. Furthermore, green nanodrug delivery systems based on environmentally safe chemical reactions or using natural biomaterials (such as plant extracts and microorganisms) are now producing innovative materials revolutionizing the field. In this review, the use of green chemistry design, synthesis, and application principles and eco-friendly synthesis techniques with low side effects are discussed. The review ends with a description of key future efforts that must ensue for this field to continue to grow.

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“…In vitro studies demonstrated the development of chemotaxis in mesenchymal progenitor cells in response to PlGF [163,164]. Also, PlGF has been found to significantly enhance the osteoinductive effect of BMP-2 [165].…”

Section: Growth Factorsmentioning

confidence: 98%

Current Trends in the Development of Materials for Bone Grafting and Spinal Fusion (Review)

Bokov¹,

Mlyavykh²,

Shirokova³

et al. 2018

Sovrem Tehnol Med

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The review addresses the currently used materials for spinal stabilization surgery by spinal fusion. Among them: autografts; allo-and xenografts; materials of synthetic and biological origin; growth factors; multipotent mesenchymal stromal cells; grafts made by 3D modeling. We discuss advantages and disadvantages of these materials as reported in the literature; with this analysis, we hope to stimulate further research into the graft biocompatibility and biointegration, especially into the issue of reparative regeneration and graft transformation into the bone tissue.

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Sustained dual release of placental growth factor-2 and bone morphogenic protein-2 from heparin-based nanocomplexes for direct osteogenesis

Cited by 33 publications

References 55 publications

Enhancing regenerative approaches with nanoparticles

Enhancing regenerative approaches with nanoparticles

A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine

Current Trends in the Development of Materials for Bone Grafting and Spinal Fusion (Review)

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