Swallowing a Surgeon: Toward Clinical Nanorobots

Sim, Seunghyun; Aida, Takuzo

doi:10.1021/acs.accounts.6b00495

Cited by 32 publications

(26 citation statements)

References 47 publications

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“…The research field of micro/nanorobots connects the advances in nanoscience and material sciences for possible applications of the new size related effects in the fields of biology, medicine, and environmental remediation . Much work has been done on the new concepts of micromotors such as microjets, Janus particles, and particle dimers in the past years, showing the possibility to construct micrometer‐sized objects with physically and chemically programmed behavior for a specific environment and specific stimuli .…”

Section: Introductionmentioning

confidence: 99%

“…Such programmed behavior patterns include catalytically driven bubble‐jet propulsion, self‐electrophoresis, self‐diffusiophoresis, self‐thermophoresis, which are connected to response to external magnetic, electric, or electromagnetic field and also to concentration gradients of chemical substances . These micromachines are proposed to be used in biomedicinal and environmental as well as in military applications . Applications of micromotors in sensing of small molecules are also developed but in much smaller extent.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Plasmonic Self‐Propelled Nanomotors for Explosives Detection via Solution‐Based Surface Enhanced Raman Scattering

Novotný

Plutnar

Pumera

2019

Adv Funct Materials

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Nanomotors represent a class of artificial machines that span the chasm between molecular motors and bigger micromotors. Their importance lies in the fact that to effectively navigate and perform tasks in a biological environment without alerting the action of the immune system, the maximal size of the object has to be well below 200 nm. Fully nanosized gold/silver core/shell plasmonic nanomotors using the seeded growth wet chemical approach, which allows high scalability of synthesis of the nanomotors compared to planar substrate-based methods, is presented. Using the nanoparticle tracking analysis, the catalysis driven enhanced diffusion of the plasmonic nanomotors in the presence of low concentrations of fuel is presented and shown that the prepared nanomotors are good candidates for a solutionbased surface-enhanced Raman spectroscopy detection of picric acid, a typical explosive. In addition to the mentioned effects, ligand-exchange is performed on the nanomotors to replace the surfactant with its thiolated analog, a combination which is already proven in literature to be stealthy to the immune response of the living organism.The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adfm.201903041. microjets, [8][9][10][11] Janus particles, [5,12,13] and particle dimers [11] in the past years, showing the possibility to construct micrometer-sized objects with physically and chemically programmed behavior for a specific environment and specific stimuli. [5,14] Such programmed behavior patterns include catalytically driven bubble-jet propulsion, [8] self-electrophoresis, [15][16][17] self-diffusiophoresis, [15,17] selfthermophoresis, [12,17] which are connected to response to external magnetic, [18] electric, [19] or electromagnetic field [20,21] and also to concentration gradients of chemical substances. [22] These micromachines are proposed to be used in biomedicinal [3] and environmental [4,6] as well as in military applications. [23] Applications of micromotors in sensing of small molecules are also developed but in much smaller extent. The sensing is usually based on (i) slowing the micromotors down by catalyst poisoning or accelerating them by providing fuel, [24,25] (ii) aggregation of the micromotors to produce higher concentrations of an analyte [26] or (iii) separation of the sensing of an analyte by collecting the micromotors be sedimentation. [26] However, direct sensing by micromotors is limited.While the area of self-propelled micromachines is well developed, the field of nanorobots, i.e., self-propelled devices of submicrometer size, is developed much less. For any micro-or nanorobots to have real-world impact, we have to use millions and billions of them. Most of the works in the field use planar substrate-based preparation technique. [17] To further push the micro/nanorobots field to real-world applications, one has to develop objects, whose synthesis is easily scalable. [27] The scalability is a property hard to fulfill for the planar-based...

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Plasmonic Self‐Propelled Nanomotors for Explosives Detection via Solution‐Based Surface Enhanced Raman Scattering

Novotný

Plutnar

Pumera

2019

Adv Funct Materials

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“…Nanotechnology is becoming everyday a more valuable resource in developing strategies of diagnostics and therapeutics; in fact, a new area is arising which is named nanomedicine [1]. From the use of nanoparticles [2] to nanorobots [3] or nanosensors [4], there is no shortage of ways to apply it to nanomedicine's benefit. Nanoparticles are particularly useful as theranostic agents, as a multifunctional platform which combine both therapeutic and diagnostic applications simultaneously [5].…”

Section: Introductionmentioning

confidence: 99%

Protein Interactions and Nanomaterials: A Key Role of the Protein Corona in Nanobiocompatibility

Ânia¹,

Emilio²,

Millán³

et al. 2018

Protein-Protein Interaction Assays

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The protein corona is still somewhat of a mysterious consequence of the nanoparticles' application in theranostics. In this review, several critical aspects related to the protein corona are described, in particular which influences more specifically its formation, how to evaluate/characterize it, and what interactions to expect when the nanoparticle and the protein corona are inside the cell. Despite these issues, which have been studied in a general way, it has been verified that there's still much information missing when it comes to specific nanoparticles. Here, a few proteins are also highlighted as examples, which have been identified as part of the protein corona; in addition, several factors related to the formation of protein corona are discussed due to their important role in the different adsorbed proteins.

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“…80 The length of these nanotubes can be controlled by the ratio between GroEL Cys and a molecularly engineered protein end-capper (SR MC ), a single ring version of GroEL Cys (Figure 2.12D). 81,82 As the length of these tubular structures is significantly affect the cellular uptake and circulation behaviour, the nanotubes that longer than 100 nm are less likely to be taken up into cells. that structurally supports the nucleus by forming mechanically tough filaments through longitudinal growth and subsequent lateral attraction.…”

Section: Light-responsive Tubulesmentioning

confidence: 99%

mentioning

confidence: 99%