Switching photochromic molecules adsorbed on optical microfibres

Wiedemann, U.; Alt, Wolfgang; Meschede, Dieter

doi:10.1364/oe.20.012710

Cited by 16 publications

(10 citation statements)

References 24 publications

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“…A significant decrease in signal was observed in the first 4 experimental cycles, falling to 50% of the initial fluorescence, as seen in Figure 4B. This decrease is likely the result of the sensor switching back to the weakly-fluorescent SP isomer under the influence of the 532 nm laser light and/or light induced parasitic side reactions that led to the formation of non-switchable by-products, a process that is not completely understood and beyond the scope of this work [55]. In comparison, the fluorescence of Rhodamine B (a fluorophore capable of excitation under the same 532 nm laser but not photoswitchable) fell to 30% of the initial fluorescence by the same photoswitching cycle in a similar experiment.…”

Section: Photoswitching In An Optical Fibrementioning

confidence: 89%

A Rationally Designed, Spiropyran-Based Chemosensor for Magnesium

et al. 2018

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Magnesium ions (Mg 2+ ) play an important role in mammalian cell function; however, relatively little is known about the mechanisms of Mg 2+ regulation in disease states. An advance in this field would come from the development of selective, reversible fluorescent chemosensors, capable of repeated measurements. To this end, the rational design and fluorescence-based photophysical characterisation of two spiropyran-based chemosensors for Mg 2+ are presented. The most promising analogue, chemosensor 1, exhibits 2-fold fluorescence enhancement factor and 3-fold higher binding affinity for Mg 2+ (K d 6.0 µM) over Ca 2+ (K d 18.7 µM). Incorporation of spiropyran-based sensors into optical fibre sensing platforms has been shown to yield significant signal-to-background changes with minimal sample volumes, a real advance in biological sensing that enables measurement on subcellular-scale samples. In order to demonstrate chemosensor compatibility within the light intense microenvironment of an optical fibre, photoswitching and photostability of 1 within a suspended core optical fibre (SCF) was subsequently explored, revealing reversible Mg 2+ binding with improved photostability compared to the non-photoswitchable Rhodamine B fluorophore. The spiropyran-based chemosensors reported here highlight untapped opportunities for a new class of photoswitchable Mg 2+ probe and present a first step in the development of a light-controlled, reversible dip-sensor for Mg 2+ .

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Section: Photoswitching In An Optical Fibrementioning

confidence: 89%

A Rationally Designed, Spiropyran-Based Chemosensor for Magnesium

et al. 2018

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“…Microstructured optical fibres were coated separately with each photoswitch using a modified "drip method" [50,51] (see Section 2.4) prior to coupling to the fluorescence setup; fluorescence and photostability measurements were then performed as described in Section 2.4. Optimization of the alignment of the MOF core to the excitation light source is typically determined by maximizing the fibre transmittance; however, this was not possible with the fluorophores pre-attached to the core as this could cause photobleaching, and the fluorophores caused an increase in fibre transmission loss due to increased absorption and scattering of the light.…”

Section: Solid State Fibre Fluorescence Measurementsmentioning

confidence: 99%

A comparative study of the fluorescence and photostability of common photoswitches in microstructured optical fibre

Stubing

Heng

Monro

et al. 2017

Sensors and Actuators B: Chemical

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 If accepted for publication, we encourage authors to link from the preprint to their formal publication via its Digital Object Identifier (DOI). Millions of researchers have access to the formal publications on ScienceDirect, and so links will help your users to find, access, cite, and use the best available version. Authors can update their preprints on arXiv or RePEc with their accepted manuscript. Please note: Cell Press, The Lancet, and some society-owned titles have different preprint policies. Information on these is available on the journal homepage. Preprints should not be added to or enhanced in any way in order to appear more like, or to substitute for, the final versions of articles. December 2016Fluorescence Abstract:The fluorescence spectra and photostability under 532 nm laser excitation of four different common photoswitches (an azobenzene, spiropyran, indolylfulgide, and a diarylperfluorocyclopentene) was investigated in a silica microstructured optical fibre. An example of each photoswitch was examined both in solution as well as physically adsorbed to the silica fibre surface. This comparison was made to determine any fluorescence behavioral differences as a result of each solution and the optical fibre fluorescence sensing platform, and to determine which photoswitch has the best performance in this light intense microenvironment. It was found that the azobenzene and the spiropyran showed the most favorable behavior; showing a stronger fluorescence response and the least degradation of the fluorescence signal.

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“…; (b) The absorbance decreases after the UV exposure has stopped. [90] As with neutral atoms, bringing single particles into contact with the evanescent field of a nanofiber has obvious potential for both sensing and spectroscopic studies. Such a technique was demonstrated by Gregor et al [91], who introduced individual charged particles to the surface of a nanofiber via a segmented linear Paul trap.…”

Section: Molecular Spectroscopymentioning

confidence: 99%

“…Due to the fact that lowering the gas pressure can reduce the pressure broadened width, longer ONF lengths are desirable for such studies. Wiedemann et al [90] recently presented a novel application for nanofibers where organic photochromic molecules show a reversible light-induced change of their absorption spectra and are thus ideal candidates for optical switching studies using nanofibers. Low concentrations of SpiroOH molecules, which photoswitch between transparent and colored when exposed to UV and white light, were drip-coated onto the nanofibers State-switching was then induced by simultaneously coupling a UV LED through the fiber.…”

Section: Molecular Spectroscopymentioning

confidence: 99%

Spectroscopy, Manipulation and Trapping of Neutral Atoms, Molecules, and Other Particles Using Optical Nanofibers: A Review

Morrissey

Deasy

Frawley

et al. 2013

Sensors

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The use of tapered optical fibers, i.e., optical nanofibers, for spectroscopy and the detection of small numbers of particles, such as neutral atoms or molecules, has been gaining interest in recent years. In this review, we briefly introduce the optical nanofiber, its fabrication, and optical mode propagation within. We discuss recent progress on the integration of optical nanofibers into laser-cooled atom and vapor systems, paying particular attention to spectroscopy, cold atom cloud characterization, and optical trapping schemes. Next, a natural extension of this work to molecules is introduced. Finally, we consider several alternatives to optical nanofibers that display some advantages for specific applications.

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Switching photochromic molecules adsorbed on optical microfibres

Cited by 16 publications

References 24 publications

A Rationally Designed, Spiropyran-Based Chemosensor for Magnesium

A Rationally Designed, Spiropyran-Based Chemosensor for Magnesium

A comparative study of the fluorescence and photostability of common photoswitches in microstructured optical fibre

Spectroscopy, Manipulation and Trapping of Neutral Atoms, Molecules, and Other Particles Using Optical Nanofibers: A Review

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