Symptomatic Gastroesophageal Reflux in Subjects With a Breathing Sleep Disorder

Valipour, Arschang; Makker, Himender; Hardy, Rebecca; Emegbo, Stephen; Toma, Tudor; Spiro, Stephen

doi:10.1378/chest.121.6.1748

Cited by 105 publications

(84 citation statements)

References 28 publications

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“…This study paired a validated GERD questionnaire and nocturnal oximetry desaturations (as a proxy for apnoeic and hypopnoeic events) to investigate the relationship between OSAS and GERD. 9 The authors found no relationship between these surrogate measures of GERD.…”

Section: Introductionmentioning

confidence: 94%

“…A more recent investigation with 228 patients also utilizing a validated questionnaire (GERQ) did not establish a relationship between OSAS and GERD. 9 Finally, as in this study recent work also utilized both polysomnography and a validated GERD questionnaire (GERD Symptom Checklist) to investigate OSAS and GERD. In 136 patients, the authors stated that their data '…failed to show a causal link between GERD and OSA'.…”

mentioning

confidence: 99%

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Symptoms of gastro‐oesophageal reflux disease and the severity of obstructive sleep apnoea syndrome are not related in sleep disorders center patients

Kim

Vorona

Winn

et al. 2005

Aliment Pharmacol Ther

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SUMMARYBackground: Studies suggest obstructive sleep apnea syndrome (OSAS) frequently manifests in patients with gastroesophageal reflux disease (GERD) and that there may be a causal relationship. Aim: To determine the relationship between OSAS and symptoms of GERD. Methods: Consecutive patients referred to the Sleep Disorders Center (SDC) 18 years and older with polysomnographically defined OSAS were evaluated prospectively for GERD using a validated symptoms questionnaire. The GERD and OSAS relationship was assessed by 1) determining frequency of GERD in patients with and without OSAS; 2) ascertaining the relationship between

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Section: Introductionmentioning

confidence: 94%

mentioning

confidence: 99%

Symptoms of gastro‐oesophageal reflux disease and the severity of obstructive sleep apnoea syndrome are not related in sleep disorders center patients

Kim

Vorona

Winn

et al. 2005

Aliment Pharmacol Ther

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“…So fo cu sing only to the ado lescents who sno re or ha ve OSA symptoms may ca u se to un de res ti ma te the sub ject. 32 Si mi lar to a study which was con duc ted in the Uni ted King dom, the aut hors conc lu ded that sympto ma tic GER was very com mon among the sub jects with a bre at hing sle ep di sor der, 33 we fo und a re la ti ons hip bet we en OSA symptoms and gas troesop ha ge al ref lux symptoms in our study (OR: 2.85, 95% CI: 1.75-4.67).…”

Section: Discussionmentioning

confidence: 98%

Frequency and Risk Factors of Sleep Problems Among High School Students Who Will Undergo University Entrance Exam as a Stressful Experience

Çifçili¹,

Ünalan²,

Kivrak³

et al. 2010

Turkiye Klinikleri J Med Sci

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Frequency and Risk Factors of Sleep Problems Among High School Students Who Will Undergo University Entrance Exam as a Stressful ExperienceA AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Pre va len ce of sle ep dis tur ban ces is 15-35%, which is mo re fre qu ent du ring ado les cen ce. Stress is known to ca u se sle ep dis tur ban ce, in par ti cu lar in som ni a. In this study it is ai med to eva lu a te the frequency of sle ep dis tur ban ces among high scho ol stu dents who will un der go a uni ver sity en tran ce exam as a stress fac tor, and re la ti ons hip of sle ep dis tur ban ces with the sug ges ted va ri ab les. M Ma at te er ri ia al l a an nd d M Me et t h ho od ds s: : This des crip tive study was con duc ted in fo ur dif fe rent types of high scho ols and a pri va te uni ver sity pre pa ring exam co ur se in Is tan bul. One se ni or and one ju ni or class from all scho ols and fo ur clas ses from the pri va te co ur se we re se lec ted by simp le ran do mi za ti on and all stu dents we re in vi ted to ta ke pla ce in the study. Of the stu dents, 324 ac cep ted to parti ci pa te and 302 who fully-fil led qu es ti on na i res we re inc lu ded in the analy sis. A self-re port qu es ti on na i re abo ut ma in symptoms of sle ep di sor ders and gas tro-esop ha ge al ref lux, chro nic whe e zing or co ugh at nights, cof fe e and/or te a in ta ke, al co hol and drug use, ci ga ret te smo king, his tory of chro nic di se a ses and cur rent me di ca ti ons was used to get the da ta. Chi-squ a re, Stu dent's t -test and bi nary lo gis tic reg res si on analy sis we re used. R Re e s su ul lt ts s: : Of the parti ci pants, 33.4% (101) re por ted ex ces si ve day ti me sle e pi ness. The par ti ci pants who re por ted in som ni a we re %20. .99 res pec ti vely). C Co on nc c l lu u s si i o on n: : Alt ho ugh sle ep dif fi cul ti es se e med to be very com mon, this was re la ted to obe sity, chro nic co ugh, gas tro-esop ha ge al ref lux symptoms, ci garet te smo king, ad dic ti ve drug use and dep res si ve symptoms mo re than exam stress. Thus the stu dents with ast hma and those who are over we ight may be as ked and ma na ged abo ut sle ep di sor ders.K Ke ey y W Wo or rd ds s: : Sle ep ini ti a ti on and ma in te nan ce di sor ders; ado les cent; stress, physi o lo gi cal; sle ep ap ne a, obs truc ti ve Ö ÖZ ZE ET T A Am ma aç ç: : Ado le san çağ da ol duk ça yay gın olan uy ku bo zuk lu ğu nun sık lı ğı %15-30'dur. Stre sin uy ku bo zukluk la rı na özel lik le in som ni a ya se bep ol du ğu bi lin mek te dir. Bu ça lış ma da bir stres fak tö rü ola rak Üni ver si te sı navı na gi re cek olan öğ ren ci ler de uy ku bo zuk luk la rı nı de ğer len dir mek ve uy ku bo zuk luk la rı nın di ğer de ğiş ken ler le iliş ki si ni göz le mek amaç lan mış tır. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Bu ta nım la yı cı ça lış ma İstan bul' da bu lu nan ve tür le ri birbi rin den fark lı dört li se de ve bir özel ders ha ne de ger çek leş ti ril miş tir. Ku ra yön te mi ile her okul dan ve...

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“…GERD occurs in up to 60% of OSA patients; comparatively, it occurs in only 20% of the general population. [14][15][16] In addition, several studies showed that OSA was more common in GERD patients than in the general population. 3,17,18 A recent study showed that the prevalence of OSA was higher over 10% in GERD patients compared with general population.…”

Section: Discussionmentioning

confidence: 99%

Association Between Non-erosive Reflux Disease and High Risk of Obstructive Sleep Apnea in Korean Population

You¹,

Oh²,

Seo³

et al. 2014

J Neurogastroenterol Motil

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Background/AimsObstructive sleep apnea is becoming more important in gastroesophageal reflux disease (GERD) patients. This study investigated the prevalence of high risk for obstructive sleep apnea in GERD patients in comparison with that in healthy controls using the Berlin Questionnaire. We also investigated the risk factors for obstructive sleep apnea in GERD patients. MethodsWe enrolled 1,007 subjects: 776 healthy controls, 115 individuals with erosive reflux disease, and 116 with non-erosive reflux disease. GERD was diagnosed and classified using endoscopy and a reflux questionnaire. The Berlin Questionnaire was used to evaluate obstructive sleep apnea. ResultsMore patients in the GERD group (28.2%) had higher risk for obstructive sleep apnea than healthy controls (20.4%, P = 0.036). More patients with non-erosive disease (32.8%) had higher risk for obstructive sleep apnea (OSA) than patients with erosive disease (20.9%) and controls (20.4%, P = 0.010). On multivariate analysis, non-erosive disease was a high risk factor for obstructive sleep apnea (odds ratio [OR], 1.82; P = 0.011). Age ≥ 55 years (OR, 1.83; P < 0.001) and a high body mass index (≥ 25 kg/m 2 ) (OR, 2.76; P < 0.001) were also identified as risk factors. Nocturnal GERD was related to high risk for OSA in non-erosive disease patients (OR, 2.97; P = 0.019), but not in erosive disease patients. ConclusionsHigh risk for OSA is more prevalent in GERD patients than in controls. Non-erosive reflux disease, age ≥ 55, and a high BMI are associated with high risk for OSA.

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Symptomatic Gastroesophageal Reflux in Subjects With a Breathing Sleep Disorder

Cited by 105 publications

References 28 publications

Symptoms of gastro‐oesophageal reflux disease and the severity of obstructive sleep apnoea syndrome are not related in sleep disorders center patients

Symptoms of gastro‐oesophageal reflux disease and the severity of obstructive sleep apnoea syndrome are not related in sleep disorders center patients

Frequency and Risk Factors of Sleep Problems Among High School Students Who Will Undergo University Entrance Exam as a Stressful Experience

Association Between Non-erosive Reflux Disease and High Risk of Obstructive Sleep Apnea in Korean Population

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