Synchronous and metachronous bilateral breast cancer: clinicopathologic characteristics and prognostic outcomes

Mruthyunjayappa, Smitha; Zhang, Kui; Zhang, Lanjing; Eltoum, Isam-Eldin; Siegal, Gene P.; Wei, Shi

doi:10.1016/j.humpath.2019.07.008

Cited by 26 publications

(25 citation statements)

References 32 publications

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“…Bilateral BC is associated with shorter relapse-free survival (RFS), but similar DSS when compared to unilateral BC. Furthermore, BSBC is associated with favourable RFS, but has similar DSS when compared to BMBC with respect to other clinicopathologic parameters in patients with bilateral BC [70].…”

Section: Therapeutic Modalities and Prognosismentioning

confidence: 89%

“…When compared to unilateral BC, bilateral breast cancer is associated with significantly lower rate of the ductal type, with a higher histologic grade, HER2 positivity and metastases in lymph nodes, without differences relating to age, race, ER and PR status, or pathologic stage of the tumour disease (Figures 3 and 4). Synchronous breast cancer is associated with a higher rate of consistency with the ER, PR, and HER2 statuses (Figure 4) as compared to metachronous bilateral breast cancer, but without any difference regarding the histologic type or grade [70]. A high-grade malignancy and multifocal contralateral breast disease are inversely proportional [46], which is why patients with BSBC often develop slowgrowing and low-grade carcinomas [71].…”

Section: Pathology Reportmentioning

confidence: 99%

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Multifocality, Multicentricity, and Bilaterality of Breast Cancer

Ilić¹

2021

Breast Cancer - Evolving Challenges and Next Frontiers

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Multifocal, multicentric, and bilateral breast tumours are either benign, precursor lesions or malignant neoplasms.A multidisciplinary review of these entities can offer clinicians a practical guidance for diagnostic and treatment procedures. Multiple synchronous (multifocal or multicentric) ipsilateral breast cancers (MSIBC) with heterogeneous histopathology require particular attention, since MSIBC tends toward more aggressive biology and higher rates of nodal positivity. Being independent of laterality, domination of the invasive carcinoma was observed in the bilateral and multifocal disease type. The TNM staging system for breast cancer does not include multifocality and multiplicity. Only the tumour with the largest diameter is considered for the pT category, neglecting the secondary foci which can make the treatment decision more difficult. MSIBC has a similar prognosis to unifocal cancers, but sometimes they might be negative prognostic parameters. Likewise, in comparison with unifocal breast cancer, MSIBC presents a different genetic pathway.

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Section: Therapeutic Modalities and Prognosismentioning

confidence: 89%

Section: Pathology Reportmentioning

confidence: 99%

Multifocality, Multicentricity, and Bilaterality of Breast Cancer

Ilić¹

2021

Breast Cancer - Evolving Challenges and Next Frontiers

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“…While the incidence of first primary breast cancer is similar for NH White women and NH Black women, and lower among Hispanic and NH Asian women in the United States, 1 several studies have reported elevated age‐adjusted incidence of second primary breast cancer following a diagnosis of invasive or in situ breast cancer for Black women relative to white women 7‐10 . However, others have failed to detect differences in CBC risk by race/ethnicity after adjusting for tumor characteristics and treatment 11‐13 . Racial/ethnic differences in risk of second cancer after lobular or ductal carcinoma in situ have also been observed 14,15 .…”

Section: Introductionmentioning

confidence: 99%

“…[7][8][9][10] However, others have failed to detect differences in CBC risk by race/ethnicity after adjusting for tumor characteristics and treatment. [11][12][13] Racial/ethnic differences in risk of second cancer after lobular or ductal carcinoma in situ have also been observed. 14,15 It remains unknown whether reported differences in CBC risk are explained or modified by socioeconomic status (SES), health insurance, differences in receipt of chemotherapy, or differences in uptake of contralateral prophylactic mastectomy (CPM) after a first breast cancer diagnosis.…”

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confidence: 98%

Race, ethnicity and risk of second primary contralateral breast cancer in the United States

Watt

John

Bandera

et al. 2021

Intl Journal of Cancer

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Breast cancer survivors have a high risk of a second primary contralateral breast cancer (CBC), but there are few studies of CBC risk in racial/ethnic minority populations. We examined whether the incidence and risk factors for CBC differed by race/ethnicity in the United States. Women with a first invasive Stage I‐IIB breast cancer diagnosis at ages 20‐74 years between 2000 and 2015 in the Surveillance, Epidemiology, and End Results Program (SEER) 18 registries were followed through 2016 for a diagnosis of invasive CBC ≥1 year after the first breast cancer diagnosis. We used cause‐specific Cox proportional hazards models to test the association between race/ethnicity and CBC, adjusting for age, hormone receptor status, radiation therapy, chemotherapy and stage at first diagnosis, and evaluated the impact of contralateral prophylactic mastectomy, socioeconomic status, and insurance status on the association. After a median follow‐up of 5.9 years, 9247 women (2.0%) were diagnosed with CBC. Relative to non‐Hispanic (NH) White women, CBC risk was increased in NH Black women (hazard ratio = 1.44, 95% CI 1.35‐1.54) and Hispanic women (1.11, 95% CI 1.02‐1.20), with the largest differences among women diagnosed at younger ages. Adjustment for contralateral prophylactic mastectomy, socioeconomic status and health insurance did not explain the associations. Therefore, non‐Hispanic Black and Hispanic women have an increased risk of CBC that is not explained by clinical or socioeconomic factors collected in SEER. Large studies of diverse breast cancer survivors with detailed data on treatment delivery and adherence are needed to inform interventions to reduce this disparity.

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“…The occurrence of bilateral breast cancer (BBC) is increasing nowadays with a reported incidence ranging between 1.4% and 12% 1,2 . However, in recent literature, patients with BBC showed a significantly worse distant relapse‐free survival (RFS) as compared to those with unilateral breast cancer (UBC), as distant metastases were frequently reported in patients with BBC 2,3 . Early detection and treatment of BBC is important to improve the overall prognosis of patients with breast cancer.…”

Section: Introductionmentioning

confidence: 99%

The hidden breast lesions: A case report of bilateral breast cancer

Dai

Bao

Tan

et al. 2021

J of Clinical Ultrasound

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Bilateral breast cancer (BBC) is rare and is associated with an unfavorable prognosis. Consequently it is crucial to improve diagnostic performance of breast cancer in the clinical setting. We report a case of BBC in a 66‐year‐old woman and describe the imaging findings, including mammography, hand‐held ultrasound, automated breast ultrasound, anatomical intelligence for breast ultrasound (AI‐breast), and magnetic resonance imaging. Only AI‐breast ultrasound successfully located the two tumors, while other imaging examinations failed to detect the tumor in the right breast.

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Synchronous and metachronous bilateral breast cancer: clinicopathologic characteristics and prognostic outcomes

Cited by 26 publications

References 32 publications

Multifocality, Multicentricity, and Bilaterality of Breast Cancer

Multifocality, Multicentricity, and Bilaterality of Breast Cancer

Race, ethnicity and risk of second primary contralateral breast cancer in the United States

The hidden breast lesions: A case report of bilateral breast cancer

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