Synchronous Occurrence of Chronic Myeloid Leukemia and Mantle Cell Lymphoma

Pathak, Prajwol; Liu, Ying; Gray, Brian A.; May, W. Stratford; Markham, Merry Jennifer

doi:10.1155/2017/7815095

Cited by 7 publications

(7 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All were adults with a median age of 63 years. These lymphomas included the following types, five diffuse large B-cell lymphoma (including our case),7,13–15 five chronic lymphocytic Leukemia/small lymphocytic lymphoma (CLL/SLL),16–20 three plasma cell neoplasm (PCN),21–23 two follicular lymphoma (FL),24,25 two Mantle Cell Lymphoma (MCL),26,27 two Mediastinal B cell lymphoma (MBCL),28,29 one large-cell NHL,30 one B-cell lymphoma,12 one mucosa-associated lymphoid tissue (MALT) lymphoma,31 one extranodal marginal zone B-cell lymphoma (EMZBCL) 32. As shown in Table 1, there are 4 cases of DCBCL with CML have been published, however, the PG-DLBCL with CML is the first report.…”

Section: Discussionmentioning

confidence: 95%

<p>A case of primary gastric diffuse large B-cell lymphoma occurring in chronic myeloid leukemia</p>

Cai

Liu

et al. 2019

OTT

View full text Add to dashboard Cite

Chronic myeloid leukemia (CML) and Non-Hodgkin Lymphoma (NHL) are two different origins of hematological malignancies, which rarely occur at the same time. Moreover, NHL secondary to CML is common in T cell lymphoma, while NHL of B cell origin is rare. Since 1999, only 22 cases with B cell lymphoma have been reported, of which 4 cases have diffuse large B-cell lymphoma (DLBCL). The lesions of DLBCL were in lymph node, liver, jejunum, and soft palate. To our knowledge, it has no report for the primary gastric DLBCL (PG-DLBCL) occurring in CML. Here we reported a 63-year-old man of chronic phase (CP) CML associated with PG-DLBCL. The patient was diagnosed with CML nearly eight years ago and was treated with imatinib and nilotinib successively. However, gastroscopy found malignant lesions in the patient’s stomach in March 2018, and the masses were diagnosed as PG-DLBCL. Subsequently, with the treatment of the RCOP + lenalidomide regimen chemotherapy for 3 cycles, the patient achieved nearly complete remission (CR).

show abstract

Section: Discussionmentioning

confidence: 95%

<p>A case of primary gastric diffuse large B-cell lymphoma occurring in chronic myeloid leukemia</p>

Cai

Liu

et al. 2019

OTT

View full text Add to dashboard Cite

show abstract

“…There have been reports of synchronic MCL and CML [15], MCL and laryngeal neuroendocrine carcinoma [16], MCL and adenocarcinoma or squamous carcinoma of the lung [17][18][19][20][21], which incidentally now includes our 5 Case Reports in Oncological Medicine case, MCL and genitourinary tract tumors [22][23][24][25], MCL and breast cancer [26,27], MCL associated with the gastrointestinal tract and endocrine tumors [4,[28][29][30][31], and MCL and papillary thyroid carcinoma [4]. An esophageal adenocarcinoma associated with MCL has not been described in any of these series; neither has an overexpression of cyclin D1 in both lymphoma cells and carcinoma cells been described.…”

Section: Discussionmentioning

confidence: 99%

Synchronous Occurrence of Splenic Pleomorphic Mantle Cell Lymphoma and Esophageal Adenocarcinoma with Overexpression of BCL1 Protein

Dabrowski

Silva

Constantinescu

et al. 2020

Case Reports in Oncological Medicine

View full text Add to dashboard Cite

Synchronous occurrences of mantle cell lymphoma (MCL), or intermediate lymphocytic lymphoma, and other malignancies are rare. Such cases present diagnostic and especially therapeutic challenges, making them of particular interest to study. We report a case of synchronic MCL and an esophageal tumor in an elderly male patient. Morphologically, the tumors were classified as splenic pleomorphic MCL and adenocarcinoma of the esophagus occurring concurrently. The pleomorphic MCL mimicked diffuse large B cell lymphoma (DLBCL) but lacked larger centroblast- or immunoblast-like cells. Curiously, both tumors overexpressed cyclin D1 by immunohistochemistry. This is an important feature that distinguishes MCL pathologically from two of its closest entities in the differential diagnosis: chronic lymphocytic leukemia and DLBCL, the latter of which mantle cells cannot transform into. The lymphoproliferation revealed IGH/CCND1 translocation by FISH, but the esophageal adenocarcinoma only showed CCND1 aneuploidy without break-apart signals. Since the gastrointestinal (GI) tract is a common site of extranodal involvement by MCL and lymphomatous polyposis can present as GI polyps, adequate care was taken to differentiate the esophageal adenocarcinoma from advanced stagings of MCL, as well as metastatic adenocarcinoma. Despite numerous immunohistochemical stainings studied, only BCL1 was demonstrated to have partial overlap in both tumors. The patient underwent esophagectomy and splenectomy. A subsequent metastatic primary lung squamous cell carcinoma was diagnosed, after which the patient expired. MCL typically presents at an advanced stage and has been deemed incurable with a prognosis of only several years. It is unclear whether the patient succumbed to complications of his MCL or the metastatic squamous cell carcinoma. Furthermore, he was lost to follow-up for a year and only received treatment after his third cancer was diagnosed. We have reviewed previous reports of synchronic mantle cell lymphoma and other solid tumors or hematological malignancies in the literature.

show abstract

“…A total of 588 genes known to be related to lymphoma were included in our gene panel; the genes are listed in Supplementary Table S4. The targeted lymphoma panel consisted of frequently mutated genes in the previously reported 26 studies of lymphoma including particularly MCL 1,8,[10][11][12]18,21,[50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68] . The mutated genes in lymphoma samples deposited in databases such as Catalogue of Somatic Mutations in Cancer (COSMIC), ClinVar, and Human Gene Mutation Database (HGMD) were also selected for broader range of targets of TPS.…”

Section: Tps and Wesmentioning

confidence: 99%

Genetic heterogeneity and prognostic impact of recurrent ANK2 and TP53 mutations in mantle cell lymphoma: a multi-centre cohort study

Jeong

Park

Yun

et al. 2020

Sci Rep

View full text Add to dashboard Cite

The molecular features of mantle cell lymphoma (MCL), including its increased incidence, and complex therapies have not been investigated in detail, particularly in East Asian populations. In this study, we performed targeted panel sequencing (TPS) and whole-exome sequencing (WES) to investigate the genetic alterations in Korean MCL patients. We obtained a total of 53 samples from MCL patients from five Korean university hospitals between 2009 and 2016. We identified the recurrently mutated genes such as SYNE1, ATM, KMT2D, CARD11, ANK2, KMT2C, and TP53, which included some known drivers of MCL. The mutational profiles of our cohort indicated genetic heterogeneity. The significantly enriched pathways were mainly involved in gene expression, cell cycle, and programmed cell death. Multivariate analysis revealed that ANK2 mutations impacted the unfavourable overall survival (hazard ratio [HR] 3.126; P = 0.032). Furthermore, TP53 mutations were related to worse progressionfree survival (HR 7.813; P = 0.043). Among the recurrently mutated genes with more than 15.0% frequency, discrepancies were found in only 5 genes from 4 patients, suggesting comparability of the TPS to WES in practical laboratory settings. We provide the unbiased genetic landscape that might contribute to MCL pathogenesis and recurrent genes conferring unfavourable outcomes. Mantle cell lymphoma (MCL) is a mature B-cell non-Hodgkin's lymphoma (NHL) accounting for 5-7% of all NHLs 1. Although MCL is uncommon (0.64/100,000 person-years), there has been a 130.9% rise in its incidence in recent years 2. Higher incidence rates have been seen in Caucasians (153.0%), Asians (96.

show abstract

Synchronous Occurrence of Chronic Myeloid Leukemia and Mantle Cell Lymphoma

Cited by 7 publications

References 15 publications

<p>A case of primary gastric diffuse large B-cell lymphoma occurring in chronic myeloid leukemia</p>

<p>A case of primary gastric diffuse large B-cell lymphoma occurring in chronic myeloid leukemia</p>

Synchronous Occurrence of Splenic Pleomorphic Mantle Cell Lymphoma and Esophageal Adenocarcinoma with Overexpression of BCL1 Protein

Genetic heterogeneity and prognostic impact of recurrent ANK2 and TP53 mutations in mantle cell lymphoma: a multi-centre cohort study

Contact Info

Product

Resources

About