Synergistic Effect of Curcuminoid and S-methyl Cysteine in Regulation of Cholesterol Homeostasis

Hasimun, Patonah; Sukandar, E. Y.; Adnyana, I Ketut; Tjahjono, Daryono Hadi

doi:10.3923/ijp.2011.268.272

Cited by 8 publications

(8 citation statements)

References 8 publications

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“…In curcumin treated group, the level of cholesterol is decreased probably due to the increase in the CYP7A1 gene expression which is a rate limiting enzyme in the biosynthesis of bile acid from cholesterol as suggested by Kim and Kim (2010). Nanocurcumin shows obviously better hypocholesterolemic effect than curcumin either by increasing total cholesterol absorption as suggested by Hasimun, Sukandar, Adnyana, and Tjahjono (2011) or by degrading and eliminating the total cholesterol (Arafa, 2005). Triglyceride lowering effect by nanocurcumin is probably due to multiple inductions of fatty acid catabolism as reported by Asai and Miyazawa (2001).…”

Section: Discussionmentioning

confidence: 99%

Potential amelioration of nicotine‐induced toxicity by nanocurcumin

Chattopadhyay

Samanta

Mukhopadhyay

et al. 2018

Drug Development Research

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Clinical Research Curcumin, a nontoxic bioactive agent of turmeric significantly reduces nicotine-induced toxicity both at cellular and genetic levels. The clinical implication of native curcumin is hindered in the target cells due to its low aqueous solubility, poor bioavailability and poor pharmacokinetics. The problem was tried to overcome by preparing nanocurcumin with a view to improve its aqueous solubility and better therapeutic efficacy against nicotine-induced toxicity. The prepared nanocurcumin was characterized by Ultraviolet-visible spectroscopy; Field emission scanning electron microscopy (FE-SEM); X-ray diffraction (XRD); and Fourier transform infrared spectroscopy (FTIR). Female albino rats of Wistar strain were daily exposed to effective dose of nicotine (2.5 mg/kg, injected subcutaneously) and supplemented with effective dose of curcumin (80 mg/kg body weight orally) or nanocurcumin (4 mg/kg body weight orally) for 21 days. The preventive efficacies of curcumin and nanocurcumin were evaluated against the changes in liver function enzymes, kidney function parameters, lipid profiles, lipid-peroxidation, anti-oxidant status, and tissues damages etc. Results revealed that nanocurcumin more effectively ameliorated the nicotine-induced toxicities at much lower concentration due to its higher aqueous solubility and more bioavailability. The nanocurcumin can be used as a potential therapeutic agent for better efficacy against nicotine-induced toxicities than native curcumin.

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Section: Discussionmentioning

confidence: 99%

Potential amelioration of nicotine‐induced toxicity by nanocurcumin

Chattopadhyay

Samanta

Mukhopadhyay

et al. 2018

Drug Development Research

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“…Our investigation revealed that triglyceride and HDL-C levels were reduced by the consumption of raw turmeric, especially for the workers who were under prolonged exposure of nicotine fumes in the factories. Curcumin present in the turmeric mainly acted as a hypo-cholesterolemic agent [38] and lowered the triglyceride level by multiple inductions of fatty acid catabolism [39]. Raw turmeric supplementation also established that it had no adverse effect on kidney and liver functions as the normal levels of urea, creatinine, SGOT and SGPT were maintained to the volunteers who consumed it.…”

Section: Discussionmentioning

confidence: 99%

Protective Role of Raw-Turmeric Rhizomes Against Nicotine-Induced Complications of Beedi (Indian Cigarette) Workers

Chattopadhyay¹

2015

Pharm Anal Acta

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Introduction: The unscientific process of beedi (Indian smoking element) production under constant exposure of nicotine dust in India induces serious health disorders to the workers. Beedi produces more tar in smoke than cigarette due to lack of any filtering process. Sometimes active consumption of beedi and other tobacco products makes the users more vulnerable to cancer, respiratory diseases and cardiovascular disorders etc.Objective: The present study was designed to observe the protective effects of raw turmeric rhizomes on health conditions of the beedi workers who were exposed to nicotine dust for 8-10 hours daily for a long duration.Methods: General health checkup, blood glucose levels, lipid profiles and the hemogram profiles etc. of the workers from two beedi factories (Canning of South 24 Parganas District and Bankura of Bankura District, both in West Bengal, India) were conducted before and after the consumption of laboratory processed raw turmeric rhizomes (80 mg/kg body weight/day by chewing) for 8 weeks. Blood samples (5 ml) were collected from all the workers before and after the completion of the study and analyzed for estimation of different parameters. Results:The results showed significant improvement in the general health conditions of the factory workers who consumed raw-turmeric rhizomes. Significant improvement of blood pressure, blood glucose levels and lipid profiles and also improvement of creatinine, serum protein and SGOT/SGPT levels of the treated volunteers were noted. The results also showed improvement in the enzymes levels of SOD, GSH and GP X in the serum of rhizomes consumed workers. Conclusion:It is concluded that turmeric rhizomes are effective in the amelioration of nicotine-induced complications. It would be a better therapeutic supplement for the improvement of health for the workers who are compelled to work under nicotinic dust environment for a long time.

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“…Turmeric has been used as a colour of food and flavouring [5,6] as well as a traditional medicine. Curcuminoids have a large variety of activities such as antioxidant to the reactive oxygen species (ROS) [7][8][9], anti-viral [10], anti-bacterial [11], diminishing the blood cholesterol level [12], the ability to treat Alzheimer's disease [13], the inhibition of a wide types of tumour cells, such as lung cancer, bladder cancer, prostate cancer, breast cancer and leukaemia cancer [14][15][16][17]. Curcumin has no toxicity and is extremely safe at high dose.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antioxidant study of new hydrazones derived from bisdemethoxycurcumin pyrazole

2017

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The antioxidant activity of new hydrazones derived from bisdemethoxycurcumin pyrazole was investigated. The study was divided into two main parts: The first one includes the synthesis and characterization of the target compounds from bisdemethoxycurcumin (BDMC), while the second step is devoted to the investigation of their antioxidant activities. In the first step of synthesis, the curcumin-pyrazole (2) was synthesized by the reaction of BDMC with hydrazine hydrate. Later, the obtained product treated with ethyl 2chloroacetate to produce curcumine ester (3), then the product was converted to hydrazide (4) by the reaction of curcumin ester (3) with hydrazine hydrate. Finally, curcumine hydrazones (5a-f) were synthesized from the reaction of hydrazide (4) with substituted aromatic aldehydes. All compounds were characterized with the aid of suitable spectroscopic techniques. The antioxidant activity of the prepared compounds was studied against the stable radical α,α-diphenyl-β-picrylhydrazyl. The study showed that only the phenolic OHcontaining compounds (2, 5b and 5f) have antioxidant activity.

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Synergistic Effect of Curcuminoid and S-methyl Cysteine in Regulation of Cholesterol Homeostasis

Cited by 8 publications

References 8 publications

Potential amelioration of nicotine‐induced toxicity by nanocurcumin

Potential amelioration of nicotine‐induced toxicity by nanocurcumin

Protective Role of Raw-Turmeric Rhizomes Against Nicotine-Induced Complications of Beedi (Indian Cigarette) Workers

Synthesis and antioxidant study of new hydrazones derived from bisdemethoxycurcumin pyrazole

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