Synergistic Effects of Flavonoids on Cell Proliferation in Hepa‐1c1c7 and LNCaP Cancer Cell Lines

Campbell, Joseph P.; King, Jennifer L.; Harmston, Matt T.; Lila, Mary Ann; Erdman, John W.

doi:10.1111/j.1750-3841.2006.00013.x

Cited by 49 publications

(26 citation statements)

References 36 publications

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“…It is interesting the kaempferol glucoside exhibited moderate cytotoxicity compared to other kaempferol and its structurally related flavones reported in the literature (Dimas et al, 2000;Gardenia Carmem et al, 2005;Nakamura et al, 2005), but dramatically antiproliferative effects, coordinate results are also available. Campbell et al (2006) reported that kaempferol (at 12.5-50 M) significantly inhibited mouse liver cancer cell line Hepa-1c1c7 and LNCaP, a human prostate cancer cell proliferation in a dose-dependent manner without cytotoxicity. Kaempferol significantly inhibited platelet-derived growth factor (PDGF)-BB-induced proliferation and without any cytotoxicity in primary cultured rat aortic vascular smooth muscle cells (VSMCs) (Kim et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

A flavonoid glycoside isolated from Smilax china L. rhizome in vitro anticancer effects on human cancer cell lines

Guoping

Zhang

et al. 2007

Journal of Ethnopharmacology

135

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Section: Discussionmentioning

confidence: 99%

A flavonoid glycoside isolated from Smilax china L. rhizome in vitro anticancer effects on human cancer cell lines

Guoping

Zhang

et al. 2007

Journal of Ethnopharmacology

135

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“…Phytochemical screening considers that every compound, regardless of their proportion in the plant, known or not, may be an active ingredient [39]. Studies suggest that combinations of phenolics naturally present in fruits and vegetables as a whole inhibit cancer cell growth more effectively than the individual compounds [40]. …”

Section: Discussionmentioning

confidence: 99%

Chemopreventive effect of Copaifera langsdorffii leaves hydroalcoholic extract on 1,2-dimethylhydrazine-induced DNA damage and preneoplastic lesions in rat colon

Senedese

Alves

Lima

et al. 2013

BMC Complement Altern Med

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BackgroundNatural antioxidants present in common foods and beverages have drawn great attention to cancer prevention due to its health benefits, remarkable lack of toxicity and side effects. Copaifera langsdorffii, known as “copaiba”, “capaiva”, or “pau-de-óleo“, belongs to the Leguminosae family and occurs in fields and grasslands in the northern and northeastern parts of Brazil. Biological studies of Copaifera corroborate its widespread use by the population. This paper describes the effects of C. langsdorffii leaves hydroalcoholic extract on the 1,2-dimethylhydrazine (DMH)-induced DNA damage and aberrant crypt foci (ACF) in the colon of male Wistar rats.MethodsThe hydroalcoholic extract of C. langsdorffii was administered to rats by gavage at daily doses of 20, 40 and 80 mg/kg body weight. To evaluate DNA damage by the comet assay, animals received the C. langsdorffii extract for seven days and a single subcutaneous injection (sc) of 1,2-dimethylhydrazine (DMH) at a dose of 40 mg/kg on day 7. Animals were sacrificed 4 h after injection of DMH, to assess DNA damage. For the ACF assay, animals were acclimatized for one week (week 1) and then treated with the C. langsdorffii extract five times a week for four weeks (weeks 2 to 5). The rats received sc injections of DMH (40 mg/kg) on days 2 and 5 of weeks 2 and 3, to induce ACF. Animals were euthanized at week 5; i.e., four weeks after the first DMH treatment.ResultsAnimals treated with different doses of the C. langsdorffii extract combined with DMH had significantly lower frequency of DNA damage as compared with the positive control (animals treated with DMH only). The percentage of reduction in the frequency of DNA damage ranged from 14.30% to 38.8%. The groups treated with 40 and 80 mg/kg C. langsdorffii extract during and after DMH treatment presented significantly lower numbers of ACF and aberrant crypts compared with the control.ConclusionThe C. langsdorffii extract significantly reduced the extent of DNA damage and ACF induced by DMH, suggesting that the extract has a protective effect against colon carcinogenesis.

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“…These anthraquinone derivatives are well known to exhibit a variety of biological activities [19], such as antimicrobial [2], antifungal [20], antitumor [21], antioxidant [22], cytotoxic [23], and hypoglycemic [24] activities. The flavonoid kaempferol has been reported to have anticancer properties [25,26]. It is clear that there is a correlation between the ethnopharmacological properties ascribed to this herbal medicine and the biological activities of these phenolic compounds.…”

Section: Published In Final Edited Form Asmentioning

confidence: 99%

Determination of pharmacologically active compounds in root extracts of Cassia alata L. by use of high performance liquid chromatography

Fernand

Dinh

Washington

et al. 2008

Talanta

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A simple high performance liquid chromatography (HPLC) method was developed and validated for the determination of six phenolic compounds, five anthraquinones (rhein, aloe-emodin, emodin, chrysophanol and physcion) and a flavonoid (kaempferol), in root extracts from Cassia alata L. Solid-phase extraction, using C 18 cartridges, was used to remove interfering substances from the root extracts. The extracts were analyzed on a C 18 column using an isocratic mobile phase which consisted of acetonitrile, methanol, and 10 mM aqueous ammonium acetate (25: 55: 20, v/v). Identification of the analytes was performed by use of standards and on-line mass spectrometric detection using atmospheric pressure chemical ionization. The concentration of the phenolic compounds in the root extracts was determined using HPLC with ultraviolet detection at 260 nm. The limits of detection obtained for the anlytes were in the range of 0.23 -4.61 ppm. The overall R.S.D. precision values (intra and inter-day) for the retention times and peak-areas were lower than 0.16% and 2.10%, respectively. In addition, the recovery of the developed method for the analysis of these phenolic compounds was determined, and ranged from 81.2 ± 4.3% to 106 ± 2%.

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Synergistic Effects of Flavonoids on Cell Proliferation in Hepa‐1c1c7 and LNCaP Cancer Cell Lines

Cited by 49 publications

References 36 publications

A flavonoid glycoside isolated from Smilax china L. rhizome in vitro anticancer effects on human cancer cell lines

A flavonoid glycoside isolated from Smilax china L. rhizome in vitro anticancer effects on human cancer cell lines

Chemopreventive effect of Copaifera langsdorffii leaves hydroalcoholic extract on 1,2-dimethylhydrazine-induced DNA damage and preneoplastic lesions in rat colon

Determination of pharmacologically active compounds in root extracts of Cassia alata L. by use of high performance liquid chromatography

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