Synergistic effects of natural compounds and conventional chemotherapeutic agents: recent insights for the development of cancer treatment strategies

Castañeda, Ana María; Meléndez, Carlos Mario; Uribe, Diego; Pedroza-Díaz, Johanna

doi:10.1016/j.heliyon.2022.e09519

Cited by 49 publications

(20 citation statements)

References 103 publications

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“…Finally, the high efficacy in neuroblastoma of DNA-topoisomerase I inhibitors (e.g., camptotechin and its derivatives irinotecan and topotecan) was demonstrated decades ago [ 63 , 64 , 65 ]; at the same time, there were many chemical–chemical and chemical–natural combinations tested to manage tumor resistance or to obtain synergistic activity [ 66 , 67 , 68 ]. In addition, in silico studies have also revealed new molecular targets and tumor inhibitors as potential cancer approaches and combined therapies [ 69 , 70 , 71 ].…”

Section: Discussionmentioning

confidence: 99%

Potential Benefits of Dietary Plant Compounds on Normal and Tumor Brain Cells in Humans: In Silico and In Vitro Approaches

Pîrvu

Neagu

Albulescu

et al. 2023

IJMS

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Neuroblastoma can be accessed with compounds of larger sizes and wider polarities, which do not usually cross the blood–brain barrier. Clinical data indicate cases of spontaneous regression of neuroblastoma, suggesting a reversible point in the course of cell brain tumorigenesis. Dual specificity tyrosine-phosphorylation-regulated kinase2 (DYRK2) is a major molecular target in tumorigenesis, while curcumin was revealed to be a strong inhibitor of DYRK2 (PBD ID: 5ZTN). Methods: in silico studies by CLC Drug Discovery Workbench (CLC) and Molegro Virtual Docker (MVD) Software on 20 vegetal compounds from the human diet tested on 5ZTN against the native ligand curcumin, in comparison with anemonin. In vitro studies were conducted on two ethanolic extracts from Anemone nemorosa tested on normal and tumor human brain cell lines NHA and U87, compared with four phenolic acids (caffeic, ferulic, gentisic, and para-aminobenzoic/PABA). Conclusions: in silico studies revealed five dietary compounds (verbascoside, lariciresinol, pinoresinol, medioresinol, matairesinol) acting as stronger inhibitors of 5ZTN compared to the native ligand curcumin. In vitro studies indicated that caffeic acid has certain anti-proliferative effects on U87 and small benefits on NHA viability. A. nemorosa extracts indicated potential benefits on NHA viability, and likely dangerous effects on U87.

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Section: Discussionmentioning

confidence: 99%

Potential Benefits of Dietary Plant Compounds on Normal and Tumor Brain Cells in Humans: In Silico and In Vitro Approaches

Pîrvu

Neagu

Albulescu

et al. 2023

IJMS

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“…[22,23] Besides natural products, small molecule inhibitors in combination with anticancer drugs induce synergistic apoptotic cell death mechanisms, thereby achieving significant efficacy with less toxicity in preclinical models. [36][37][38] Resveratrol, a small molecular weight natural phytoalexin derived from grapes, was previously shown to activate caspase-3 and caspase-9 via CD95 or TRAIL-mediated signaling and hence reduce cell growth potential. [39] Louisa and colleagues reported that SC promotes apoptosis induction in HCT116 P53-/cells by activating procaspase-8 and −9 and subsequently activates PARP-1 cleavage.…”

Section: Discussionmentioning

confidence: 99%

Sclareol induces cell cycle arrest and ROS‐mediated apoptosis and ferroptosis in lung adenocarcinoma cells

Rah,

Shafarin,

Hamad

et al. 2023

J Biochem & Molecular Tox

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Sclareol (SC) has shown significant anticancer activity against breast and colon cancers among others. However, its ability to precipitate similar anticancer effects in lung cancer has yet to be investigated. To address this issue, SC‐treated lung adenocarcinoma cells (A549) were assessed for viability and functional competence as well as the expression of genes related to apoptosis and cell cycling. Our results demonstrated that SC treatment inhibited A549 cell clonogenic features and reduced their migration and invasion potential in a dose‐dependent manner. Mechanistically, SC treatment downregulated the expression of cyclin D1 and survivin and upregulated that of p21 and p16, which was associated with a significant increase in the percentage of SubG0 cells. SC treatment is also associated with the induction of both the extrinsic and intrinsic apoptotic pathways, as evidenced by the increased expression and splitting of PARP1 and procaspases 3 and 9 and the reduced expression of antiapoptotic proteins Bcl‐2 and Bcl‐xL. Increased cell death in SC‐treated cells is likely to have resulted from the induction of ferroptosis as suggested by the reduced expression of FPN and the inhibition of the anti‐ferroptosis regulator GPX4. In conclusion, the data presented here suggest that SC can reduce lung carcinoma cell growth and metastasis and promote cell death.

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“…Thus the leaf extract used in this study or specific bioactive compounds may also have the property to modulate the tumor microenvironment. It was reported that different natural compounds can act synergistically with several existing chemotherapeutic agents to enhance their efficacy (Castañeda et al, 2022). It was also reported that natural products like polyphenols, alkaloids, terpenoids, saponins, and bioactive polysaccharides have the potential to be used as adjuvant therapy and cancer immunotherapy (Dong et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Effect ofLantana camaraethanolic leaf extract on survival and migration of MDA-MB-231 triple negative breast cancer cell line

Pal

Sanyal

Das

et al. 2023

Preprint

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Breast cancer is considered as a leading cause of cancer related death worldwide. The development of chemotherapeutic resistance and the production of undesirable side effects steer the search for new potential candidates with therapeutic implications. Lantana camara has been reported to cure a number of ailments, with few studies showing its cytotoxic effect on breast cancer cell lines. However, the impact of Lantana camara on triple negative breast cancer cells is largely obscure to date. The present study investigated the effect of ethanolic extract of Lantana camara leaves on the triple negative breast cancer cell line, MDA-MB-231. We found that Lantana camara leaf extract induced cytomorphological changes and exhibited a growth inhibitory effect on MDA-MB-231 cells in a dose-dependent manner. The extract was observed to induce G0/G1 cell cycle arrest. Nuclear staining of the cells exposed to Lantana camara leaf extract suggested the presence of condensed nuclei and the result of flow cytometry analysis confirmed cell death by apoptosis. Lantana camara leaf extract also reduced the migration of MDA-MB-231 cells as evidenced by the wound healing assay results. In summary, this study demonstrates the efficacy of the extract to produce growth-inhibitory and anti-migratory effects on MDA-MB-231 cells. Our results thus suggest that Lantana camara leaf extract can be considered a potent source of chemotherapeutic agents for triple-negative breast cancer treatment.

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Synergistic effects of natural compounds and conventional chemotherapeutic agents: recent insights for the development of cancer treatment strategies

Cited by 49 publications

References 103 publications

Potential Benefits of Dietary Plant Compounds on Normal and Tumor Brain Cells in Humans: In Silico and In Vitro Approaches

Potential Benefits of Dietary Plant Compounds on Normal and Tumor Brain Cells in Humans: In Silico and In Vitro Approaches

Sclareol induces cell cycle arrest and ROS‐mediated apoptosis and ferroptosis in lung adenocarcinoma cells

Effect ofLantana camaraethanolic leaf extract on survival and migration of MDA-MB-231 triple negative breast cancer cell line

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