Synergistic Photodynamic and Photothermal Antibacterial Nanocomposite Membrane Triggered by Single NIR Light Source

Sun, Jing; Song, Lingjie; Ye, Fan; Tian, Limei; Luan, Shifang; Niu, Shichao; Ren, Luquan; Ming, Weihua; Zhao, Jie

doi:10.1021/acsami.9b07037

Cited by 196 publications

(146 citation statements)

References 57 publications

Supporting

Mentioning

146

Contrasting

Order By: Relevance

“…As a transparent optical organ of eyeball, phototherapy has broad prospects on the ophthalmic disease. Phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), are widely used to treat infections and exhibit a distinct advantage over conventional chemical antimicrobial agents 27 . Considering the complex structure of the eye, a bactericidal strategy of mild temperature photothermal assisted therapy, which remains the antibacterial effect but reduces thermal damage to nearby tissues, is more suitable for endophthalmitis 28 , 29 .…”

Section: Introductionmentioning

confidence: 99%

Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis

Yang¹,

He²,

Qiao³

et al. 2020

Theranostics

View full text Add to dashboard Cite

Rationale: Endophthalmitis, which is one of the severest complications of cataract surgeries, can seriously threaten vision and even lead to irreversible blindness owing to its complicated microenvironment, including both local bacterial infection and severe inflammation. It is urgent to develop a comprehensive treatment for both anti-bacterial and anti-inflammatory effects. Methods: Herein, we developed AuAgCu 2 O-bromfenac sodium nanoparticles (AuAgCu 2 O-BS NPs), which was designed to combine anti-bacterial and anti-inflammatory effects for integrated therapy of endophthalmitis after cataract surgery. The AuAgCu 2 O-BS NPs could eradicate methicillin-resistant Staphylococcus aureus (MRSA) bacterial strain relied on their photodynamic effects and the release of metal ions (Ag + and Cu + ) by the hollow AuAgCu 2 O nanostructures mediated mild photothermal effects. The anti-inflammatory drug, bromfenac sodium, released from the nanoparticles were able to significantly reduce the local inflammation of the endophthalmitis and promote tissue rehabilitation. In vivo bacterial elimination and anti-inflammation were confirmed by a postcataract endophthalmitis rabbit model. Results: Excellent antibacterial ability of AuAgCu 2 O-BS NPs was verified both in vitro and in vivo . Ophthalmological clinical observation and pathologic histology analysis showed prominent treatment of inflammatory reaction. Importantly, the mild temperature photothermal effect not only promoted the release of metal ions and bromfenac sodium but also avoided the thermal damage of the surrounding tissues, which was more suitable for the practical application of ophthalmology due to the complex structure of the eyeball. Moreover, superior biocompatibility was approved by the preliminary toxicity investigations, including low cytotoxicity, negligible damage to major organs, and stable intraocular pressure. Conclusions: Our studies of nanosystem provide a promising synergic therapeutic strategy for postcataract endophthalmitis treatment with favorable prognosis and promise in clinical translations.

show abstract

Section: Introductionmentioning

confidence: 99%

Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis

Yang¹,

He²,

Qiao³

et al. 2020

Theranostics

View full text Add to dashboard Cite

show abstract

“…When the concentration was greater than 100 μg/mL, the final temperature of RBCM-NW-G reached values as high as 50 °C. This temperature has the ability to sterilize without damaging normal tissues [ 43 , 44 ]. The photothermal effect of particles also depends on the laser density, which in turn, has an important effect on the particle temperature.…”

Section: Resultsmentioning

confidence: 99%

Erythrocyte membrane-camouflaged nanoworms with on-demand antibiotic release for eradicating biofilms using near-infrared irradiation

Ran

Qiu

et al. 2021

Bioactive Materials

View full text Add to dashboard Cite

The increase in the number of resistant bacteria caused by the abuse of antibiotics and the emergence of biofilms significantly reduce the effectiveness of antibiotics. Bacterial infections are detrimental to our life and health. To reduce the abuse of antibiotics and treat biofilm-related bacterial infections, a biomimetic nano-antibacterial system, RBCM-NW-G namely, that controls the release of antibiotics through near infrared was prepared. The hollow porous structure and the high surface activity of nanoworms are used to realize antibiotic loading, and then, biomimetics are applied with red blood cell membranes (RBCM). RBCM-NW-G, which retains the performance of RBCM, shows enhanced permeability and retention effects. Fluorescence imaging in mice showed the effective accumulation of RBCM-NW-G at the site of infection. In addition, the biomimetic nanoparticles showed a longer blood circulation time and good biocompatibility. Anti-biofilm test results showed damage to biofilms due to a photothermal effect and a highly efficient antibacterial performance under the synergy of the photothermal effect, silver iron, and antibiotics. Finally, by constructing a mouse infection model, the great potential of RBCM-NW-G in the treatment of in vivo infections was confirmed.

show abstract

“…The hybrid nanomaterials make a difference in the separation and purification of biomolecules or the design of multimodal bioimaging probes. Noble metals such as a silver shell modified on the surface of UCNPs can enhance UCL efficiency by surface plasmon coupled emission to produce a multimodal hybrid material, which can be used for photothermal therapy [ 121 ]. By adjusting the thickness of the silver layer, the wavelength of the UCNP surface plasmon resonance can be adjusted to 980 nm, and bioimaging by upconversion emission can be performed simultaneously under single wavelength illumination [ 122 ].…”

Section: Synthesis and Functionalization Of Upconversion Nanomaterialmentioning

confidence: 99%

Recent progress in the development of upconversion nanomaterials in bioimaging and disease treatment

et al. 2020

View full text Add to dashboard Cite

Multifunctional lanthanide-based upconversion nanoparticles (UCNPs), which feature efficiently convert low-energy photons into high-energy photons, have attracted considerable attention in the domain of materials science and biomedical applications. Due to their unique photophysical properties, including light-emitting stability, excellent upconversion luminescence efficiency, low autofluorescence, and high detection sensitivity, and high penetration depth in samples, UCNPs have been widely applied in biomedical applications, such as biosensing, imaging and theranostics. In this review, we briefly introduced the major components of UCNPs and the luminescence mechanism. Then, we compared several common design synthesis strategies and presented their advantages and disadvantages. Several examples of the functionalization of UCNPs were given. Next, we detailed their biological applications in bioimaging and disease treatment, particularly drug delivery and photodynamic therapy, including antibacterial photodynamic therapy. Finally, the future practical applications in materials science and biomedical fields, as well as the remaining challenges to UCNPs application, were described. This review provides useful practical information and insights for the research on and application of UCNPs in the field of cancer.

show abstract

Synergistic Photodynamic and Photothermal Antibacterial Nanocomposite Membrane Triggered by Single NIR Light Source

Cited by 196 publications

References 57 publications

Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis

Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis

Erythrocyte membrane-camouflaged nanoworms with on-demand antibiotic release for eradicating biofilms using near-infrared irradiation

Recent progress in the development of upconversion nanomaterials in bioimaging and disease treatment

Contact Info

Product

Resources

About