Synergistic photothermal antibacterial therapy enabled by multifunctional nanomaterials: progress and perspectives

Abstract

In recent years, infection caused by drug-resistant bacteria has become a serious public health problem. The exploration of antibacterial therapies other than antibiotics has attracted more and more attention. Photothermal...

Nanomaterials as multimodal photothermal agents (PTAs) against ‘Superbugs’

“…18 Nanomaterials and polymers show excellent photothermal conversion efficacies and thus have become favorable candidates in this domain. [19][20][21] Apart from nanoparticles, some other nanostructures such as nanofibers, nanosheets, and nanoflowers have emerged as functional photothermal agents in recent times. 22 Herein, we aim to discuss their design rationale and introduce some non-conventional PTT systems, which showed remarkable efficiencies in the recent past.…”

Mild-temperature photothermal assisted CuSi nanowires for promoting infected wound healing

“…For example, after NIR irradiation, the temperature of infected sites increased to 56 °C which was much higher than surrounding normal skin, and showed excellent antibacterial activity against methicillin-resistant S. aureus (MRSA) (Qian et al, 2018). However, the application of hyperthermia may also cause damage to normal tissues, and even delay wound healing, making PTT hard be implemented alone (Xu et al, 2018;Huo et al, 2021;Bai et al, 2023). Therefore, the combination of PPT with other antibacterial treatment methods to achieve high antibacterial efficiency under mild temperatures is becoming the focus of photothermal antibacterial therapy.…”

Microenvironment Restruction of Emerging 2D Materials and their Roles in Therapeutic and Diagnostic Nano‐Bio‐Platforms

“…Compared with conventional nanomaterials, the emerging 2D materials offer distinct advantages such as 1) the sheet-like 2D structure with atomic thickness offers them better flexibility, large surface area, and facile modification availability [38][39][40][41][42] ; 2) tunable bonding states and band structures between layers [37,43,44] ; 3) superior chemical and physical properties, including photothermal, photodynamic, electrochemical, optical, biocatalytic, etc. [45][46][47][48] These characteristics and advantages have driven researchers to create abundant therapeutic and diagnostic NBPFs via the emerging 2D materials (2D-NBPFs) in diverse biomedical fields. [6,23,42,[49][50][51] The critical points for designing efficient 2D-NBPFs include i) the physiological stability and biocompatibility; ii) the bioad-hesiveness and surface functional groups; iii) molecularly programmed specific binding ability and stimuli-responsiveness; iv) the active centers/adsorption sites and the interfacial microenvironments of carrier materials.…”

“…[52][53][54] In recent years, there are some reviews have summarized the biomedical applications of these emerging 2D-NBPFs, including applications in drug delivery, cancer therapy, tissue engineering, bioimaging, and biosensing. [45,46,48] However, few of them pay attention to engineering and analyzing the complex molecularly restructured microenvironments and biofunctionalities of 2D-NBPFs that have well-defined chemical structures or configurations. [47,53,[55][56][57] To direct the future engineering of 2D-NBPFs, this timely review aims to offer a multidisciplinary summarization of modulating the molecularly restructured microenvironments and disclosing the structure-property correlations of diverse biofunctionalities in 2D-NBPFs (Scheme 1).…”