Synergistic properties of bioavailable phenolic compounds from olive oil: electron transfer and neuroprotective properties

Malezieu, Morgane Lambert de; Courtel, Patricia; Sleno, Lekha; Abasq, Marie-Laurence; Ramassamy, Charles

doi:10.1080/1028415x.2019.1666480

Cited by 11 publications

(12 citation statements)

References 30 publications

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“…Our work is in line with the study of the EVOO-ArOH neuroprotective capacities and how the Mix could synergistically prevent oxidative stress-induced neuronal death, as observed in previous work [9]. With this aim, we questioned whether the oxidized compounds from the Mix (Mix-Ox) or from Ole (Ole-Ox) could prevent H 2 O 2 -induced neuronal death.…”

Section: Neuroprotective Effect Of Oxidized Ole and MIXsupporting

confidence: 78%

“…In this previous study, also evaluating superoxide or hydrogen peroxide inhibition, a significant difference in reactivity of Mixes was observed. Indeed the presence of the catechol Ole in combination with the two monophenols (Tyr, p-Cou) displayed higher reactivity than when the catechol hydroxytyrosol was present [9]. The enhancement of the activity was attributed to possible coupled redox and intermolecular reactions generating stronger H-atom or electron donor compounds when Ole is present.…”

Section: Introductionmentioning

confidence: 97%

“…The chemistry behind these assays involves H-atom transfer (HAT), radical-chain breaking, and electron transfer (ET) mechanisms, which have been detailed by Apak [4]. The monophenols, tyrosol (Tyr), and p-coumaric acid (p-Cou) are weaker H-atom and electron donors, even though p-Cou could reveal superoxide scavenging capacity almost as high as Ole and OH-Tyr of 18 ascribed to its higher conjugative effects [5][6][7][8][9]. In these non-cellular assays, the reactivity of the ArOH-EVOO engages among others the formation of oxidized species, which have been partially analyzed so far by NMR or HPLC-MS.…”

Section: Introductionmentioning

confidence: 99%

“…An interesting highlight is that some molecule combinations enhance the antioxidant efficacy in both non-cellular and cellular in vitro assays by synergic effects [1,[21][22][23]. Indeed, our previous work has shown for instance that a low concentration equimolar mix of Ole, Tyr, and p-Cou (0.1 and 1 µM) reduces intracellular ROS and protein carbonyl levels, and prevents the activation of Nrf2 and NF-κB in neuronal SK-N-SH cells challenged with H2O2 or Paraquat [9]. This is much lower than the concentration of any one individual molecule required to observe similar effects.…”

Section: Introductionmentioning

confidence: 99%

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UV-Vis Spectroelectrochemistry of Oleuropein, Tyrosol, and p-Coumaric Acid Individually and in an Equimolar Combination. Differences in LC-ESI-MS2 Profiles of Oxidation Products and Their Neuroprotective Properties

et al. 2019

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Major phenolic compounds from olive oil (ArOH-EVOO), oleuropein (Ole), tyrosol (Tyr), and p-coumaric acid (p-Cou), are known for their antioxidant and neuroprotective properties. We previously demonstrated that their combination could potentiate their antioxidant activity in vitro and in cellulo. To further our knowledge of their electron-transfer properties, Ole, Tyr, and p-Cou underwent a spectroelectrochemical study, performed either individually or in equimolar mixtures. Two mixtures (Mix and Mix-seq) were prepared in order to determine whether distinct molecules could arise from their simultaneous or sequential oxidation. The comparison of Liquid Chromatography–Electrospray Ionization–Tandem Mass Spectrometry (LC-ESI-MS2) profiles highlighted the presence of specific oxidized products found in the mixes. We hypothesized that they derived from the dimerization between Tyr and Ole or p-Cou, which have reacted either in their native or oxidized forms. Moreover, Ole regenerates when the Mix undergoes oxidation. Our study also showed significant neuroprotection by oxidized Ole and oxidized Mix against H2O2 toxicity on SK-N-SH cells, after 24 h of treatment with very low concentrations (1 and 5 nM). This suggests the putative relevant role of oxidized Ole products to protect or delay neuronal death.

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Section: Neuroprotective Effect Of Oxidized Ole and MIXsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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UV-Vis Spectroelectrochemistry of Oleuropein, Tyrosol, and p-Coumaric Acid Individually and in an Equimolar Combination. Differences in LC-ESI-MS2 Profiles of Oxidation Products and Their Neuroprotective Properties

et al. 2019

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“…Oleuropein acts as a scavenger of superoxide, nitric oxide, 2,2 -azinobis-(3-ethylbenzothiazoline-6-sulfonic acid, and 2,2-diphenyl-1-picrylhydrazyl radicals [221,222]. Various research groups have demonstrated that treatment with oleuropein and its derivatives inhibit the accumulation of ROS and prevent the progression of PD pathology [97,98,120]. Palazzi et al demonstrated that in vitro incubation with oleuropein aglycone stabilizes α-synuclein monomers to prevent pathological aggregation [97].…”

Section: Oleuropeinmentioning

confidence: 99%

Dietary Antioxidants and Parkinson’s Disease

Park

Ellis

2020

Antioxidants

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Parkinson’s disease (PD) is a neurodegenerative disorder caused by the depletion of dopaminergic neurons in the basal ganglia, the movement center of the brain. Approximately 60,000 people are diagnosed with PD in the United States each year. Although the direct cause of PD can vary, accumulation of oxidative stress-induced neuronal damage due to increased production of reactive oxygen species (ROS) or impaired intracellular antioxidant defenses invariably occurs at the cellular levels. Pharmaceuticals such as dopaminergic prodrugs and agonists can alleviate some of the symptoms of PD. Currently, however, there is no treatment to halt the progression of PD pathology. Due to the nature of PD, a long and progressive neurodegenerative process, strategies to prevent or delay PD pathology may be well suited to lifestyle changes like dietary modification with antioxidant-rich foods to improve intracellular redox homeostasis. In this review, we discuss cellular and genetic factors that increase oxidative stress in PD. We also discuss neuroprotective roles of dietary antioxidants including vitamin C, vitamin E, carotenoids, selenium, and polyphenols along with their potential mechanisms to alleviate PD pathology.

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