Synergy of cystamine and pyraclostrobin against Fusarium graminearum involves membrane permeability mitigation and autophagy enhancement

Luan, Shaorong; Chen, Yongjun; Wang, Xiaohua; Yan, Dongmei; Xu, Jialin; Cui, Hairong; Huang, Qingchun

doi:10.1016/j.pestbp.2022.105287

Pesticide Biochemistry and Physiology

2022

DOI: 10.1016/j.pestbp.2022.105287

|View full text |Cite

Synergy of cystamine and pyraclostrobin against Fusarium graminearum involves membrane permeability mitigation and autophagy enhancement

Shaorong Luan¹,

Yongjun Chen

Xiaohua Wang³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

2024

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Antifungal Activity of Novel Isoindoline‐2‐Yl Putrescines as Potential Autophagy‐Activated Fungicide

Zhu,

Huang,

Wang

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

The exacerbation of plant fungal diseases necessitates the development of new fungicides to prevent outbreaks. In this study, five novel isoindoline‐2‐yl putrescines (ISPs) were synthesized, and their synthetic procedures and gram‐scale preparation were explored. When tested at 50 μg mL‐1, ISPs did not significantly inhibit mycelial growth on agar plates. However, at 100 μg mL‐1, they demonstrated remarkable in vivo efficacy in mitigating Botrytis cinerea infection, especially ISP3 showed curative and protective activities of 91.9% and 92.6%, respectively. Moreover, ISP3 also effectively halted lesion expansion of gray mold, Sclerotic rot, and Fusarium scabs, while inducing excessive malformed top mycelial branches of B. cinerea and Sclerotinia sclerotiorum, suppressing sclerotia formation in S. sclerotiorum, and triggering autophagic vacuolization with numerous autophagosomes in the mycelia of these fungi. Molecular docking revealed that ISP3 effectively bound to the active site of BcAtg3, forming hydrogen bonds with Ser279, Gly343, Asp370, and Asp13, along with establishing a stable salt bridge with Asp13. Furthermore, ISP3 possessed favorable ADMET properties. These findings highlight ISP3 as a promising antifungal candidate through autophagy activation.

show abstract

Antifungal Activity of Novel Isoindoline‐2‐Yl Putrescines as Potential Autophagy‐Activated Fungicide

Zhu,

Huang,

Wang

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

Fabrication of pH-responsive nanoparticles for co-delivery of fungicide and salicylic acid with synergistic antifungal activity

Huang,

Wang,

Tang

et al. 2024

Journal of Cleaner Production

View full text Add to dashboard Cite

Ascendancy of pyraclostrobin nanocapsule formulation against Rhizoctonia solani: From a perspective of fungus

Ma,

Yu,

et al. 2023

Pesticide Biochemistry and Physiology

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Synergy of cystamine and pyraclostrobin against Fusarium graminearum involves membrane permeability mitigation and autophagy enhancement

Cited by 3 publications

References 40 publications

Antifungal Activity of Novel Isoindoline‐2‐Yl Putrescines as Potential Autophagy‐Activated Fungicide

Antifungal Activity of Novel Isoindoline‐2‐Yl Putrescines as Potential Autophagy‐Activated Fungicide

Fabrication of pH-responsive nanoparticles for co-delivery of fungicide and salicylic acid with synergistic antifungal activity

Ascendancy of pyraclostrobin nanocapsule formulation against Rhizoctonia solani: From a perspective of fungus

Contact Info

Product

Resources

About