Synthese einiger β‐Aryl‐β‐methoxy‐äthylamine

Merz, K. W.; Fink, Jürgen

doi:10.1002/ardp.19562890705

Cited by 24 publications

(9 citation statements)

References 23 publications

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“…Due to the limited commercial availability of bacillibactin, we used azotochelin, a biscatechol from Azotobacter vinelandii, as a model catechol siderophore. Azotochelin was synthetized as described previously (37, 38). The B.…”

Section: Methodsmentioning

confidence: 99%

Iron Homeostasis in Bacillus subtilis Requires Siderophore Production and Biofilm Formation

Rizzi

Roy

Bellenger

et al. 2019

Appl Environ Microbiol

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Iron acquisition is of fundamental importance for microorganisms, since this metal is generally poorly bioavailable under natural conditions. In the environment, most bacteria are found tightly packed within multicellular communities named biofilms. Here, using the soil Gram-positive bacterium Bacillus subtilis, we show that biofilm formation and the production of siderophores, i.e., small molecules specifically binding metals, are both essential to ensure Fe uptake from the medium and maintain cellular Fe homeostasis. The biofilm matrix appears to play an important role favoring the efficient usage of siderophores. Taken together, our results demonstrate a close link between biofilm formation and iron acquisition in B. subtilis, allowing a better comprehension of how bacteria can cope with metal limitation under environmental conditions.

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Section: Methodsmentioning

confidence: 99%

Iron Homeostasis in Bacillus subtilis Requires Siderophore Production and Biofilm Formation

Rizzi

Roy

Bellenger

et al. 2019

Appl Environ Microbiol

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“…All chemicals used were of analytical grade from Sigma or Fisher Bioblock and were used without further purification. Azotochelin was synthesized according to published procedures (6,22). Protochelin was extracted and purified from an A. vinelandii culture medium as previously described (9; Bellenger et al, unpublished).…”

Section: Methodsmentioning

confidence: 99%

Vanadium Requirements and Uptake Kinetics in the Dinitrogen-Fixing Bacterium Azotobacter vinelandii

Bellenger

Wichard

Kraepiel

2008

Appl Environ Microbiol

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Vanadium is a cofactor in the alternative V-nitrogenase that is expressed by some N 2 -fixing bacteria when Mo is not available. We investigated the V requirements, the kinetics of V uptake, and the production of catechol compounds across a range of concentrations of vanadium in diazotrophic cultures of the soil bacterium Azotobacter vinelandii. In strain CA11.70, a mutant that expresses only the V-nitrogenase, V concentrations in the medium between 10 ؊8 and 10 ؊6 M sustain maximum growth rates; they are limiting below this range and toxic above. A. vinelandii excretes in its growth medium micromolar concentrations of the catechol siderophores azotochelin and protochelin, which bind the vanadate oxoanion. The production of catechols increases when V concentrations become toxic. Short-term uptake experiments with the radioactive isotope 49 V show that bacteria take up the V-catechol complexes through a regulated transport system(s), which shuts down at high V concentrations. The modulation of the excretion of catechols and of the uptake of the V-catechol complexes allows A. vinelandii to precisely manage its V homeostasis over a range of V concentrations, from limiting to toxic.

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“…Only a few compounds show activity against Escherichia coli and Salmonella typhi but of a low order (50-100 gg/ml). In the case of gram-positive bacteria, some of these compounds show fairly high activity (2)(3)(4)(5)(6)(7)(8)(9)(10)…”

Section: -[4-(2-furoylmentioning

confidence: 99%

Synthesis and identification of the major metabolites of prazosin formed in dog and rat

Althuis¹,

Hess²

1977

J. Med. Chem.

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The 6-O-demethyl and 7-O-demethyl analogues of the new antihypertensive drug prazosin [2-[4-(2-furoyl)-piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline hydrochloride] have been unequivocally synthesized via separate ten-step reaction sequences starting from isovanillin and vanillin, respectively. The 6-O-demethyl derivative was found to be identical with the major prazosin metabolite formed in dog and rat, while the 7-O-demethyl derivative was identical with another, less prevalent but significant metabolite. Two minor metabolites of prazosin, 2-(1-piperazinyl)-4-amino-6,7-dimethoxyquinazoline and 2,4-diamino-6,7-dimethoxyquinazoline, are also described. All four metabolites are less potent blood pressure lowering agents in dogs than prazosin but may contribute to its antihypertensive effect, since they account for a major portion of the administered dose.

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Synthese einiger β‐Aryl‐β‐methoxy‐äthylamine

Cited by 24 publications

References 23 publications

Iron Homeostasis in Bacillus subtilis Requires Siderophore Production and Biofilm Formation

Iron Homeostasis in Bacillus subtilis Requires Siderophore Production and Biofilm Formation

Vanadium Requirements and Uptake Kinetics in the Dinitrogen-Fixing Bacterium Azotobacter vinelandii

Synthesis and identification of the major metabolites of prazosin formed in dog and rat

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