Synthese und biologische Wirksamkeit neuer N,N‐disubstituierter 5‐Alkyliden‐ bzw. 5‐Aralkyliden‐3‐aminorhodanine

Abstract

Numerous novel N,N-disubstituted 5-alkyliden- or 5-aralkyliden-3-aminorhodanines 2 have been prepared by condensation of carbonyl compounds with 1. The effectiveness of some derivatives in an "akanthose test" with hairless mice was shown.

Recent Heterocyclic Compounds from (1,3‐Dioxo‐2,3‐dihydro‐1H‐inden‐2‐ylidene)propanedinitrile

“…Considerable attention has been drawn to the condensation reaction between 3‐aminothiazolidine‐2‐thion‐4‐one (3‐aminorhodanine, 16 ) and both aldehydes and ketones to give 3‐alkylidene and/or arylidene rhodanines . The reaction of 1 with 16 afforded the condensation product 2‐(3‐amino‐4‐oxo‐2‐thioxothiadi‐azolidine‐5‐ylidene)‐1,3‐indanedione 17 via a nucleophilic attack of the rhodanine methylene function on the dicyanomethylene carbon atom of 1 , followed by elimination of a molecule of malononitrile (Scheme ) .…”