Syntheses of 8-Substituted-2- Carboxy-4-(4-Halophenyl)-2,3-Dihydro-1,5-Benzothiazepines

Sharma, Arti; Pant, Seema; Sharma, C. K.; Pant, U. C.

doi:10.1080/10426509608038779

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“…benzothiazepines 23 and tetra cyclic benzopyranobenzo thiazepines 24 have been reported. Herein is reported the synthesis of having various substituents at positions 2, 4 and 8.…”

Section: Research Articlementioning

confidence: 99%

Piperidine Mediated Synthesis of Hetero Chalcones and -Substituted-2, 5-dihydro-2-(2-furanyl)-4-(2-thienyl)-1,5-benzothiazepines as Antibacterial Agents

Bhasker¹,

Prashanthi²,

Reddy³

et al. 2013

Chem Sci Trans

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The reactions of 5-substituted-2-amino benzenethiols with hetero chalcones 3 have been carried out in dry toluene containing catalytic amount of piperidine, the products, 8-substituted-2,5dihydro-2-(2-furanyl)-4-(2-thienyl)-1,5-benzo thiazepines 5 and hetero chalcones 3 were synthesized by piperidine mediated condensation of an ethanolic solution of a 1-thiophen-2-yl-ethanone 2 with corresponding furan-2-carbaldehyde 1. The structures have been established on the basis of elemental (C, H, N) analysis, IR, 1 H NMR, Mass spectral data. The compounds 3 and 5 were screened for antimicrobial activities against a variety of bacterial agent.

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“…benzothiazepines 23 and tetra cyclic benzopyranobenzo thiazepines 24 have been reported. Herein is reported the synthesis of having various substituents at positions 2, 4 and 8.…”

Section: Research Articlementioning

confidence: 99%