Synthesis and Anti-inflammatory Activity of Some Newer Potential Isoxazoline Derivatives of Indole

Abstract

Some new 3-acetyl-2-carboxy-5-methoxy indole (1), 2-carboxy-5-methoxy-3-indolyl chalcones (2-6), 3-(2'-carboxy-5'-methoxyindol-3'-yl)-5-(substituted phenyl)-2-isoxazolines (7-11), 3-(2'carboxy-5'-methoxyindol-3'-yl)-4-(substituted phenyl) aminomethyl-5-(substituted phenyl)-2isoxazolines (12-26) derivatives of indole have been synthesized in the present study. All the prepared compounds have been characterized by elemental and spectral analysis. All the above said compounds have been evaluated for their anti-inflammatory activity and some of them have been found as potential anti-inflammatory agents.

Sodium Storage in Coal/Biomass‐Derived Carbon/Carbon 3D Networks

“…Stretching vibration characteristic peaks marked by a dotted line, can be attributed to NÀ H or OÀ H (3420 cm À 1 ), À CH 2 (2850 and 2920 cm À 1 ), C=N (1600 cm À 1 ), CÀ OÀ N (1240 cm À 1 ), CÀ N (1050 cm À 1 ) and NÀ O (900 cm À 1 ), respectively. [24][25][26][27][28][29] According to previous report, the sample derived from pure chitosan exhibits two new peaks of C=N and NÀ O compared to uncalcined chitosan, indicating that N is transferred to newly formed graphite lattice from chitosan. [26] In addition, because of high-temperature treatment, oxygen functional groups containing C=O bonds (1750 cm À 1 ) on all the samples disappeared, which is different from our previous work.…”

“…To investigate the functional groups on the surface of materials, FT‐IR spectra from 700 to 4000 cm −1 were collected and shown in Figure d. Stretching vibration characteristic peaks marked by a dotted line, can be attributed to N−H or O−H (3420 cm −1 ), −CH 2 (2850 and 2920 cm −1 ), C=N (1600 cm −1 ), C−O−N (1240 cm −1 ), C−N (1050 cm −1 ) and N−O (900 cm −1 ), respectively . According to previous report, the sample derived from pure chitosan exhibits two new peaks of C=N and N−O compared to uncalcined chitosan, indicating that N is transferred to newly formed graphite lattice from chitosan .…”

A brief review of the biological potential of indole derivatives

“…Indole-based chalcone derivatives reported as COX-1 and COX-2 inhibitor by Ozdemir et al Compound 3-(5-Bromo-1H-indol-3-yl)-1-(4-cyanophenyl)prop-2-en-1one (21) and compound 3-(5-methoxy-1H-indol-3-yl)-1-(4-(methylsulfonyl)phenyl)prop-2-en-1-one (22) were found to demonstrate a significant activity [13].…”

“…Some new derivatives of 3-(2'-carboxy-5'-mehoxyindol-3'-yl)-5-(substituted phenyl)-2-isoxazolines have been prepared with less CVS and CNS activities but good anti-inflammatory activity by Prajapati et al All the compounds were investigated for anti-inflammatory activity and compound 5methoxy-3-(3-phenylacryloyl)-1H-indole-2-carboxylic acid (38) showed maximum activity (64.20%) at 50 mg/kg [22]. A series of nitrogen and carbon substituted bisindoles were synthesized and investigated for antimicrobial agents by Singh et al The N-benzyl moiety or morpholine or pyrrolidine at position 3 and xylidine or butane or propane as the bridge between the indoles were good for activity.…”