Synthesis and Antibacterial Activity of some Heterocyclic β-Enamino Ester Derivatives with 1,2,3-triazole

Chen, Mingdong; Shan, Lu; Yuan, Guangpu; Yang, Shiyan; Du, Xiaoli

doi:10.1515/hc.2000.6.5.421

Cited by 81 publications

(32 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compounds (26a-c) and (27) inhibited the growth of H 37 Rv strain at concentrations of 8 lg/mL. These compounds (26,27) found even active in the concentrations 32-64 lg/ mL. From SAR, the 2-mercaptobenzothiazoles conjugated to 1,2,3-triazole ring were more active when compared to the aromatic/aliphatic/cyclic secondary amines attached through an amide linkage.…”

Section: 23-triazole Derivatives For Treatment Of Tuberculosismentioning

confidence: 95%

Triazole: A Promising Antitubercular Agent

et al. 2015

View full text Add to dashboard Cite

Tuberculosis is a contagious disease with comparatively high mortality worldwide. The statistics shows that around three million people throughout the world die annually from tuberculosis and there are around eight million new cases each year, of which developing countries showed major share. Therefore, the discovery and development of effective antituberculosis drugs with novel mechanism of action have become an insistent task for infectious diseases research programs. The literature reveals that, heterocyclic moieties have drawn attention of the chemists, pharmacologists, microbiologists, and other researchers owing to its indomitable biological potential as anti-infective agents. Among heterocyclic compounds, triazole (1,2,3-triazole/1,2,4-triazole) nucleus is one of the most important and well-known heterocycles, which is a common and integral feature of a variety of natural products and medicinal agents. Triazole core is considered as a privileged structure in medicinal chemistry and is widely used as 'parental' compounds to synthesize molecules with medical benefits, especially with infection-related activities. In the present review, we have collated published reports on this versatile core to provide an insight so that its complete therapeutic potential can be utilized for the treatment of tuberculosis. This review also explores triazole as a potential targeted core moiety against tuberculosis and various research ongoing worldwide. It is hoped that this review will be helpful for new thoughts in the quest for rational designs of more active and less toxic triazole-based antituberculosis drugs.

show abstract

Section: 23-triazole Derivatives For Treatment Of Tuberculosismentioning

confidence: 95%

Triazole: A Promising Antitubercular Agent

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Gill et al reported some novel [1,2,3] triazoles clubbed with fluorine benzimidazole (5) series of H37Rv strain inhibitors which were found to be potentially active against Mycobacterium tuberculosis on the basis of promising results of preliminary antimicrobial study. Some of the derivatives under further evaluation are showing improved activity compared to rifampin [31].…”

Section: Pharmacological Significance Of Triazole Scaffoldmentioning

confidence: 99%

“…It follows from the literature that the triazole derivatives possess a wide range of pharmacological activities such as antimicrobial [3,4], analgesic [5], anti-inflammatory, local anaesthetic [6], anticonvulsant [7], antineoplastic [8], antimalarial [9], antiviral [10], antiproliferative [11], and anticancer activities [12]. Many triazole-based derivatives are available as medicines [13].…”

Section: Introductionmentioning

confidence: 99%

Pharmacological significance of triazole scaffold

Kharb

Sharma

Yar

2010

Journal of Enzyme Inhibition and Medicinal Chemistry

483

236

View full text Add to dashboard Cite

“…On the other hand, 1,2,3-triazoles and their derivatives have emerged as powerful pharmacophores [23], gaining interest for their various biological activities [24e26] as chemotherapeutic agents [27,28], potent antimicrobial [29], anti-inflammatory [30,31], local anaesthetic [32], anticonvulsant [33], antineoplastic [34], antimalarial [35] and antiviral activity [36]. Considering such a biological importance of 1,2,3-triazoles, a new series of the diarylhetherocycles having the aryl groups positioned on N 1 and C 4 of the triazole nucleus was projected to explore further productive and selective interactions with COXs active site.…”

Section: Designmentioning

confidence: 99%