Synthesis and anticancer property of three new Ca (II) compounds derived from tetrazole carboxylate ligands

Synthesis, Characterization and Bioactivity of Three Tetrazole Carboxylate Based Co(II) Complexes

“…As a multifunctional material, coordination complexes have been widely prepared and actively used in the treatment of cancer, and the complexes based on tetrazole‐carboxylate have shown a good inhibitory effect on tumor cell proliferation in the application of anticancer. In a previous study, a series of tetrazole‐carboxylate‐based mononuclear ruthenium(II) complexes were synthesized, which exhibited low dark toxicity, high excited‐state reactivity and excellent biocompatibility when used in photodynamic therapy, and Cu(II), Sm(III), Ca(II) complexes based on these ligands also have low IC 50 values against cancer cells [20–25] . In this study, we focus on Co(II) complexes based on H 3 tzpha, Hpztzma and Hpytza (Scheme 1).…”

“…In a previous study, a series of tetrazole-carboxylate-based mononuclear ruthenium(II) complexes were synthesized, which exhibited low dark toxicity, high excited-state reactivity and excellent biocompatibility when used in photodynamic therapy, and Cu(II), Sm(III), Ca(II) complexes based on these ligands also have low IC 50 values against cancer cells. [20][21][22][23][24][25] In this study, we focus on Co(II) complexes based on H 3 tzpha, Hpztzma and Hpytza (Scheme 1). As a result, three complexes [Co 3 (tzpha) 2 (4,4'bipy) 3…”

Syntheses, crystal structures and thermal decomposition studies of two novel Mn(ii)-MOFs with tetrazole-based carboxylic acids

“…[3][4][5][6][7][8][9][10] In our previous work, a series of tetrazole-based carboxylic acids such as N-(1-carboxymethyltetrazole-5-yl)-N-(2 0 -carboxymethyltetrazole-5 0 -yl)amine, 11,12 1,3-bis(2-carboxymethyltetrazol-5-yl) benzene (H 2 L 1 ), [13][14][15] 1,4-bis(2-carboxymethyltetrazol-5-yl)benzene, 16 1,3,5-tri(2-carboxymethyltetrazol-5-yl)benzene, 2,14,[17][18][19] and 2-(5-(3pyridyl)tetrazol-2-yl)propionic acid (HL 2 ) [20][21][22][23][24] have been designed and successfully prepared. Their MOFs with Mg(II), Ca(II), Sr(II), Ba(II), Pb(II), Mn(II), Co(II), Zn(II), and Cd(II) ions have been synthesized and the related properties like luminescence, 2,11,16 thermal decomposition, 13,16,17,20,21,24 proton conduction 2 and anticancer activity 22,23,25 have also been researched. As a continuation of our investigation on the tetrazole-based carboxylic acids, herein we present two new Mn(II)-MOFs: [Mn(L 1 )(DMF)(H 2 O)]Á0.375H 2 O (1) and [Mn(L 2 ) 2 ] (2) derived from H 2 L 1 and HL 2 ligands (Scheme 1).…”

Bifunctional tetrazole–carboxylate ligand based Zn(ii) complexes: synthesis and their excellent potential anticancer properties

“…In our previous research, Ru/Ca( ii )/Cu( ii )-tetrazole–carboxylate complexes showed low IC 50 on HeLa cells, indicating that the diversity and versatility of organic ligands can be harnessed to develop coordination complexes with promising anti-cancer activities. 22–28 Since studies on complexes based on tetrazole-carboxylate-based ligands for cancer treatment are far from satisfactory. Zn( ii ) is a trace element essential for the normal function of cells and plays an important role in the development of various cancers.…”