Synthesis and antidiabetic activity of selenium nanoparticles in the presence of polysaccharides from Catathelasma ventricosum

Liu, Yuntao; Zeng, Siqi; Liu, Yixi; Wu, Wenjing; Shen, Yingbin; Zhang, Lan; Cheng, Lei; Chen, Hong; Liu, Aiping; Shen, Lihua; Hu, Bin; Wang, Caixia

doi:10.1016/j.ijbiomac.2018.03.161

Cited by 129 publications

(59 citation statements)

References 35 publications

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“…This indicates that MPE has the hypoglycemic activity and there is a synergistic effect between MPE and SeNPs. The antidiabetic efficacies of MPE and SeNPs have been severally verified34., 48., 49., 50.. Neither MPE nor SeNPs alone are able to produce satisfactory curative effects due to insufficient bioactivity and pathological complexity of DM.…”

Section: Resultsmentioning

confidence: 99%

Selenium-layered nanoparticles serving for oral delivery of phytomedicines with hypoglycemic activity to synergistically potentiate the antidiabetic effect

Deng

Wang

et al. 2019

Acta Pharmaceutica Sinica B

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Diabetes mellitus (DM) remains a great challenge in treatment due to pathological complexity. It has been proven that phytomedicines and natural medicines have prominent antidiabetic effects. This work aimed to develop selenium-layered nanoparticles (SeNPs) for oral delivery of mulberry leaf and Pueraria Lobata extracts (MPE), a group of phytomedicines with significant hypoglycemic activities, to achieve a synergic antidiabetic effect. MPE-loaded SeNPs (MPE-SeNPs) were prepared through a solvent diffusion/in situ reduction technique and characterized by particle size, ζ potential, morphology, entrapment efficiency (EE) and drug loading (DL). The resulting MPE-SeNPs were 120 nm around in particle size with EE of 89.38% for rutin and 90.59% for puerarin, two marker components in MPE. MPE-SeNPs exhibited a slow drug release and good physiological stability in the simulated digestive fluid. After oral administration, MPE-SeNPs produced significant hypoglycemic effects both in the normal and diabetic rats. Ex vivo intestinal imaging and cellular examinations demonstrated that MPE-SeNPs were provided with outstanding intestinal permeability and transepithelial transport aptness. It was also revealed that MPE-SeNPs could alleviate the oxidative stress, improve the pancreatic function, and promote the glucose utilization by adipocytes. Our study provides new insight into the use of integrative nanomedicine containing phytomedicines and selenium for DM treatment.

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Section: Resultsmentioning

confidence: 99%

Selenium-layered nanoparticles serving for oral delivery of phytomedicines with hypoglycemic activity to synergistically potentiate the antidiabetic effect

Deng

Wang

et al. 2019

Acta Pharmaceutica Sinica B

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“…By adding Catathelasma ventricosum polysaccharides (CVPs) to the redox system of selenite and ascorbic acid, spherical CVPs–selenite NPs with particle size approx. 50 nm were prepared, and based on serum profiles and antioxidant enzyme levels, it could be concluded that CVPs–selenite NPs showed a notably higher antidiabetic activity ( p < 0.05) than other SeNPs, selenocysteine, and Na 2 SO 3 [205].…”

Section: Other Functional Applications Of Human Supplementsmentioning

confidence: 99%

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

2019

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Dietary supplements and foods for special medical purposes are special medical products classified according to the legal basis. They are regulated, for example, by the European Food Safety Authority and the U.S. Food and Drug Administration, as well as by various national regulations issued most frequently by the Ministry of Health and/or the Ministry of Agriculture of particular countries around the world. They constitute a concentrated source of vitamins, minerals, polyunsaturated fatty acids and antioxidants or other compounds with a nutritional or physiological effect contained in the food/feed, alone or in combination, intended for direct consumption in small measured amounts. As nanotechnology provides “a new dimension” accompanied with new or modified properties conferred to many current materials, it is widely used for the production of a new generation of drug formulations, and it is also used in the food industry and even in various types of nutritional supplements. These nanoformulations of supplements are being prepared especially with the purpose to improve bioavailability, protect active ingredients against degradation, or reduce side effects. This contribution comprehensively summarizes the current state of the research focused on nanoformulated human and veterinary dietary supplements, nutraceuticals, and functional foods for special medical purposes, their particular applications in various food products and drinks as well as the most important related guidelines, regulations and directives.

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“…The use of elemental Se in the form of NPs for different biological applications gained a lot of attention lately, because of several proposed advantages compared with other forms of Se, including higher bioavailability [ 98 ], lower toxicity [ 41 , 99 , 100 , 101 ], potential for local delivery of high doses into cancer cells [ 102 ]; possibility to be modified, stabilized and functionalized by various polymers such as chitosan [ 103 , 104 , 105 , 106 ] or other polysaccharides [ 107 , 108 , 109 , 110 , 111 , 112 ], proteins [ 113 , 114 ], or even combinations between them [ 115 , 116 , 117 ], smaller molecules such as polyphenols [ 118 , 119 , 120 , 121 ], sialic acids [ 122 , 123 ], folic acid or folate (as folate–chitosan smart-shell nanocapsules) [ 124 , 125 , 126 ], and other organic acids [ 37 ]. Chemical, physical, or biological methods are used for producing SeNPs [ 37 ], each having its own advantages and disadvantages.…”

Section: Conventional and Next-generation Selenium Dietary Supplemmentioning

confidence: 99%

Selenium Analysis and Speciation in Dietary Supplements Based on Next-Generation Selenium Ingredients

Constantinescu-Aruxandei

Frîncu

Capră

et al. 2018

Nutrients

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Selenium is essential for humans and the deficit of Se requires supplementation. In addition to traditional forms such as Se salts, amino acids, or selenium-enriched yeast supplements, next-generation selenium supplements, with lower risk for excess supplementation, are emerging. These are based on selenium forms with lower toxicity, higher bioavailability, and controlled release, such as zerovalent selenium nanoparticles (SeNPs) and selenized polysaccharides (SPs). This article aims to focus on the existing analytical systems for the next-generation Se dietary supplement, providing, at the same time, an overview of the analytical methods available for the traditional forms. The next-generation dietary supplements are evaluated in comparison with the conventional/traditional ones, as well as the analysis and speciation methods that are suitable to reveal which Se forms and species are present in a dietary supplement. Knowledge gaps and further research potential in this field are highlighted. The review indicates that the methods of analysis of next-generation selenium supplements should include a step related to chemical species separation. Such a step would allow a proper characterization of the selenium forms/species, including molecular mass/dimension, and substantiates the marketing claims related to the main advantages of these new selenium ingredients.

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Synthesis and antidiabetic activity of selenium nanoparticles in the presence of polysaccharides from Catathelasma ventricosum

Cited by 129 publications

References 35 publications

Selenium-layered nanoparticles serving for oral delivery of phytomedicines with hypoglycemic activity to synergistically potentiate the antidiabetic effect

Selenium-layered nanoparticles serving for oral delivery of phytomedicines with hypoglycemic activity to synergistically potentiate the antidiabetic effect

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

Selenium Analysis and Speciation in Dietary Supplements Based on Next-Generation Selenium Ingredients

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