Synthesis and antifungal activities of new fluconazole analogues with azaheterocycle moiety

Synthesis, Characterization and Pharmacological Screening of Some Substituted 1,2,3- & 1,2,4-Triazoles

“…The infrared spectra of compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10) showed the characteristic absorption bands of >C=N and C-N of triazole ring at 1562-1598 cm -1 and 1313-1365 cm -1 respectively, which confirmed the formation of triazole ring.…”

“…In the 1 H-NMR spectra of compounds (1-5), the proton signal for the CH of the triazole ring was observed as a singlet between 5.32-5.87 ppm and which was absent in compounds (6)(7)(8)(9)(10) due to the presence of -SH group. The proton signal for the S-H proton on triazole ring was observed in these compounds (6-10) as a singlet at 11.79-12.68 ppm.…”

“…The biological profile of triazoles derivatives is very extensive [1][2][3] . Compounds bearing a symmetrical triazole moiety are reported to show a broad spectrum of pharmacological activities such as antibacterial [4][5][6][7] , antifungal [8][9][10][11] , antimicrobial [12][13][14] , antimycobacterial [15][16] , antioxidant 17 , analgesic 18,19 , antipyretic 20 , anticancer [21][22] , anticonvulsant 23 and anti-inflammatory [24][25][26] activities.…”

Pharmacological significance of triazole scaffold

“…Therefore, current research efforts are mainly focused on optimisation of the side chain attached to the pharmacophore. Optimisation of the side chain has led to the development of new compounds with better pharmacological activities [26,28,29].…”

New 3-(2-pyridyl)-1,2,4-triazole derivatives and their palladium (II) complexes

“…Amongst available five-membered ring systems, triazoles represent an interesting class of compounds due to the presence of three nitrogens [1][2][3]. 1,2,4-Triazole derivatives show diverse pharmacological activities and have been examined as antitumor [4], antibacterial [5], antifungal [6] and antiviral agents [7].…”