Synthesis and antimicrobial activity of pyrimidinyl 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles

Synthesis and antitumor activity of new isolated and fused heterobicyclic nitrogen systems containing 1,3,4-thiadiazole moiety derived from N1,N2-diaryl hydrazine compound

“…Recently, functionally 1,2,4-triazine derivatives showed an important biological activity such as anti-HIV, and anticancer [21], antioxidant [22], anti-inflammatory [23], antifungal [24], herbicidal [25] and antibacterial [26,27] agents. Also, 1,3,4thiadiazoles containingsmall heterocyclic nitrogen nucleus exhibited a greatspectrum biological activity as anti-inflammatory [28], anticancer [29,30], antimicrobial [31,32], anti-HIV, and antitumor [33], and antimycotic [34] agents. Based on these important observations, the present research gives a combination of small heterocyclic nitrogen molecules with 1,3,4-thiadiazole moiety to getnovel isolated and/ or fused heteropolycyclic systems as thiazolo-1,2,4-triazines in view of their antitumor activity.…”

Synthesis and antitumor activity of new isolated and fused heterobicyclic nitrogen systems containing 1,3,4-thiadiazole moiety derived from N1,N2-diaryl hydrazine compound

“…Recently, functionally 1,2,4-triazine derivatives showed an important biological activity such as anti-HIV, and anticancer [21], antioxidant [22], anti-inflammatory [23], antifungal [24], herbicidal [25] and antibacterial [26,27] agents. Also, 1,3,4thiadiazoles containingsmall heterocyclic nitrogen nucleus exhibited a greatspectrum biological activity as anti-inflammatory [28], anticancer [29,30], antimicrobial [31,32], anti-HIV, and antitumor [33], and antimycotic [34] agents. Based on these important observations, the present research gives a combination of small heterocyclic nitrogen molecules with 1,3,4-thiadiazole moiety to getnovel isolated and/ or fused heteropolycyclic systems as thiazolo-1,2,4-triazines in view of their antitumor activity.…”

Dinuclear cobalt and nickel complexes of a mercaptoacetic acid substituted 1,2,4-triazole ligand: syntheses, structures and urease inhibitory studies

“…On complexation, bioactive ligands may improve their bioactivity profiles and inactive ligands may acquire pharmacological propertie; also, the toxicity of the metal ions can be reduced (Milacic & Dou, 2009). 4H-1,2,4-Triazoles are well-known aromatic five-membered heterocycles which exhibit broad bioactivity (Madhu Sekhar et al, 2018). In addition, they are very strong N-atom donors towards d-metal ions and can be readily deprotonated (Aromí et al, 2011;Castiñ eiras et al, 2019).…”