Synthesis and Antimicrobial Activity of Some Pyrazoline Derivatives of 4(3H)‐Quinazolinones.

Panda, Jagannath; Srinivas, S.; Rao, M. E. Bhanoji; Panda, C. S.

doi:10.1002/chin.200326174

Cited by 2 publications

(2 citation statements)

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“…Since the discovery that 3-methylpyrazole and 4-ethylpyrazole have potential medicinal value, there has been a rapid growth in synthesizing new derivatives of pyrazole as anticancer (Manfredini et al 1992;Komeda et al 2000;Gamage et al 2002;MoukhaChafiq et al 2002;Rostom et al 2003;Duivenvoorden et al 2005;Park et al 2005;Keter et al 2009a), antibacterial (Jungheim 1989;Aiello et al 2000;Genin et al 2000a;Kucukguzel et al 2000;El-Gaby et al 2000;Farghaly et al 2001;Moukha-Chafiq et al 2002;Haque et al 2002;Kaymakcıoglu and Rollas 2002;Panda et al 2002;Adnan and Abdel-Aziem 2004;Tanitame et al 2004;Akbas and Berber 2005;Bekhit et al 2005;Bildirici et al 2007;Abunada et al 2008;Radi et al 2010), antiparasitic (Garg et al 1973;Rathelot et al 2002), antiviral (Comber et al 1991;Manfredini et al 1992;Storer et al 1999;Johansson et al 2002;Rostom et al 2003;Sweeney et al 2008), analgesics (Menozzi et al 1997;Pinto et al 1999) antiglycemic agents (Bauer et al 1968;Kees et al 1996;Bebernitz et al 2001) and even as anti-inflammatory agents …”

Section: N N Hmentioning

confidence: 99%

Perspective: the potential of pyrazole-based compounds in medicine

2011

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Pyrazoles are widely used as core motifs for a large number of compounds for various applications such as catalysis, agro-chemicals, building blocks of other compounds and in medicine. The attractiveness of pyrazole and its derivatives is their versatility that allows for synthesis of a series of analogues with different moieties in them, thus affecting the electronics and by extension the properties of the resultant compounds. In medicine pyrazole is found as a pharmacophore in some of the active biological molecules. While pyrazole derivatives have been extensively studied for many applications including anticancer, antimicrobial, anti-inflammatory, antiglycemic, anti-allergy and antiviral, much less has been reported on their metal counterparts in spite of the fact that metals have been shown to impart activity to ligands. Thus this perspective is intended to demonstrate the potential of pyrazole and pyrazolyl metal complexes in the areas of drug discovery and development. Several examples, that include palladium, platinum, copper, gold, zinc, cobalt, nickel, iron, copper, silver and gallium complexes, are used to bolster the above point. For the purposes of this review three areas are discussed, that is pyrazole metal complexes as: (i) anticancer, (ii) antibacterial/parasitic and (iii) antiviral agents.

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Section: N N Hmentioning

confidence: 99%

Perspective: the potential of pyrazole-based compounds in medicine

2011

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“…This gave a great impetus to the search for potential pharmacologically active drugs carrying pyrazole substituents. Pyrazolyl pyrazoline derivatives were found to possess therapeutic activities such as antiinflammatory [3] antimicrobial [4], antiallergic [5], antidiabetic [6] and cardiovascular [7]. The efficiency of the pyrazole derivatives was increased by introducing charged core in its structure either as a cationic (pyrazolium) or anionic center (carboxylate, sulfate …).…”

Section: Introductionmentioning

confidence: 99%

Pyrazole Derived Cationic Surfactants and their Tin and Copper Complexes: Synthesis, Surface Activity, Antibacterial and Antifungal Efficacy

Negm

Said²,

Morsy

2010

J Surfact & Detergents

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Five membered heterocyclic cationic 3-pyrazolium surfactants namely: 2-[2-(alkyloxy)-2-oxoethyl]-3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-3-pyrazolium bromide (decyl-; dodecyl-) and their copper and tin complexes were synthesized, their structures were confirmed using different spectroscopic tools. The IR spectra of the metal complexes showed that these compounds exhibit a tetrahedron structure with the transition metal ion (M 2? ) at the center and the cationic ligands arranged in the apexes, while the halide ions in the center. The synthesized compounds were evaluated as biocides against different types of bacteria and fungi. The biological activity data showed that the cationic surfactants exhibit moderate to high efficacy against the tested microorganisms (either bacteria or fungi). While, complexation of these cationic surfactants with Cu (II) and Sn (II) ions the antimicrobial activity was strongly increased. The surface activity of these compounds were discussed and correlated to their chemical structure and the type of substituents on the heterocyclic moiety. Meanwhile, the antimicrobial assay was correlated to the surface activities of the synthesized compounds.

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Synthesis and Antimicrobial Activity of Some Pyrazoline Derivatives of 4(3H)‐Quinazolinones.

Cited by 2 publications

References 1 publication

Perspective: the potential of pyrazole-based compounds in medicine

Perspective: the potential of pyrazole-based compounds in medicine

Pyrazole Derived Cationic Surfactants and their Tin and Copper Complexes: Synthesis, Surface Activity, Antibacterial and Antifungal Efficacy

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