Synthesis and application of boronic acid‐functionalized magnetic adsorbent for sensitive analysis of salbutamol residues in pig tissues

Abstract

Salbutamol (SAL) is the most widely used β2 -agonist drug for asthma and chronic obstructive pulmonary patients, but it is also often abused as feed additive. In recent years, the abuse of SAL has led to a large number of food safety incidents. Therefore, the monitoring of SAL residues in animal products is very important. A highly selective boronate affinity magnetic adsorbent was synthesized and developed for detection of trace levels of SAL residues in pig tissue samples. The obtained Fe3O4@SiO2@FPBA(4-formylphenylboronic acid) magnetic adsorbent showed good adsorption ability to catechol and SAL, and then it was successfully applied as special magnetic solid-phase phase extraction adsorbent coupled with high-performance liquid chromatography (HPLC) for simultaneous isolation and determination of cis-diol compounds. The binding capacity of catechol and SAL reached 96 and 50 µmol/g, respectively. The method was successfully established for the detection of trace levels of SAL in pig tissue samples. The linear range extended from 0.32 to 800 µg/kg (R(2) = 0.9994). The limit of detection of SAL was 0.19 µg/kg. The recoveries were satisfactory (89.5-108.0%) at three spiked levels with RSD between 2.1 and 11.3%. These results indicated that the method has potential for enrichment and detection of trace levels of SAL residual in animal food products.

Facile synthesis of a boronate affinity sorbent from mesoporous nanomagnetic polyhedral oligomeric silsesquioxanes composite and its application for enrichment of catecholamines in human urine

“…Elemental analysis and ICP-AES results summarized in Table S1 validate the successful incorporation of AAPBA with Fe 3 O 4 @POSS. The B% calculated according to the N% is in general in accord with the ICP-AES results and is found to be 953 μmol g -1 , which is much higher than that of the reported magnetic boronate affinity materials [21,23,[39][40][41]42] as listed in Table 1. The high content of functional boronic acid groups should give thanks to the rich active vinyl groups exposed on the surface of porous structured Fe 3 O 4 @POSS, which is thereby beneficial to improve the binding capacity of the resultant affinity material Fe 3 O 4 @POSS [7,9].…”

“…To provide reliable quantification, establishing calibration curves by using a matched matrix that spiked with standard target analytes are preferred [8,41,42].…”

“…Not given 570 Ovalbumin:20.4 Transferrin: 2.1 Fe 3 O 4 @MPS @MPBA [40] Not given 180 Ovalbumin:17.7 Transferrin: 1.9 Fe 3 O 4 @SiO 2 -FPBA [41] Two steps modification on Fe 3 O 4 @SiO 2 Not given 189 Catechol: 96 Dalbutamol: 50 Fe 3 O 4 @PEI -FPBA [42] Two steps modification on a Detection limits (LODs) were calculated as three times the signal-to-noise ratio (S/N = 3).…”

Facile preparation of a high‐capacity boronate‐affinity adsorbent based on low‐cost commercial supports for selective enrichment of cis‐diol‐containing biomolecules

“…Figure (inset plot) shows the Langmuir fitting curve; the maximum adsorption capacity of PGMA@FPBA adsorbent was calculated to be 448 μmol/g (Table S2). Compared with other boronate‐affinity adsorbents (Table ), the PGMA@FPBA was prepared with only one step and exhibited a higher binding capacity than the boronate‐affinity materials, except for one boronate‐affinity material . Moreover, the adsorption equilibrium was achieved within 1 min, indicating faster adsorption kinetics than other reported boronate‐affinity materials.…”

Employment of modified Fe3O4 nanoparticles using thermo‐sensitive polymer for extraction and pre‐concentration of cefexime in biological samples

“…Among them, magnetic nanoparticles have attracted extensive attention owing to their wide range of applications in magnetic resonance imaging (Seo et al, ), drug delivery (Zhang et al, ) and hyperthermia treatment (Mornet, Vasseur, Grasset, & Duguet, ). Also, these nanoparticles (NPs) can be used for analytical applications (Fan, Wang, & Wei, ; Hussain, Alajmi, & Ali, ; Li, Liu, Zhang, Liu, & Wu, ; Ni, Chen, Dong, Tian, & Bai, ; Zhao, Liao, & Yang, ). To perform sample treatment, Fe 3 O 4 NPs play a vital role in analytical nanotechnology.…”