Synthesis and atomic force microscopy observations of the single-peptide nanotubes and their micro-order assemblies

Nakanishi, Toru; Okamoto, Hajime; Nagai, Yukiko; Takeda, Kyozaburo; Obataya, Ikuo; Mihara, Hisakazu; Azehara, Hiroaki; Suzuki, Yasuyuki; Mizutani, Wataru; Furukawa, Katsuko; Torimitsu, Keiichi

doi:10.1103/physrevb.66.165417

Cited by 20 publications

(21 citation statements)

References 11 publications

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“…The length of the peptide nanotubes ranges between 100 and 500 nm. Both values are consistent with experimental and theoretical studies of single‐peptide nanotubes consisting of eight‐membered rings of D ‐ and L ‐amino acids 16. The height of the 2D fibrous aggregates, shown in Figure 2, is equal to those of single‐peptide nanotubes which implies that the aggregates are most likely formed during the surface drying procedure.…”

supporting

confidence: 88%

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Peptide–Polymer Hybrid Nanotubes

et al. 2005

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supporting

confidence: 88%

“…This imparts the nanotubes with a defined hollow core and enables simple access to the functional groups for modification of the surface chemistry. The side‐chain functional groups of the peptide can have an influence on the formation of either single‐peptide nanotubes, or higher‐order 3D aggregates 16…”

mentioning

confidence: 99%

Peptide–Polymer Hybrid Nanotubes

et al. 2005

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“…There are some other materials (no carbon), which possess ability to perform the conformation of nanorings and nanotubes [75,76].…”

Section: Nanomaterials Characteristics Properties Applications (Exampmentioning

confidence: 99%

Nanotechnology on Duty in Medical Applications

Kubik

Bogunia‐Kubik²,

Sugisaka³

2005

CPB

234

112

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At the beginning of 21(st) century, fifty years after discovery of deoxyribonucleic acid (DNA) double helix structure, scientific world is faced with a great progress in many disciplines of biological research, especially in the field of molecular biology and operating on nucleid acid molecules. Many molecular biology techniques have been implemented successfully in biology, biotechnology, medical science, diagnostics, and many more. The introduction of polymerase chain reaction (PCR) resulted in improving old and designing new laboratory devices for PCR amplification and analysis of amplified DNA fragments. In parallel to these efforts, the nature of DNA molecules and their construction have attracted many researchers. In addition, some studies concerning mimicking living systems, as well as developing and constructing artificial nanodevices, such as biomolecular sensors and artificial cells, have been conducted. This review is focused on the potential of nanotechnology in health care and medicine, including the development of nanoparticles for diagnostic and screening purposes, the manufacture of unique drug delivery systems, antisense and gene therapy applications and the enablement of tissue engineering, including the future of nanorobot construction.

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“…Self‐assembling peptide nanotubes (SPNs), formed from cyclic oligopeptides consisting of various amino acids, are widely studied for their potential applications in areas such as biology and materials science 3–6. In contrast to the morphologies found in inorganic nanostructures, the nanotubes formed by cyclopeptide aggregate into bundles3–9 that may have applications in the preparation of nanosized wires 7, 10. Recently, it was reported that the self‐assembling morphologies could be controlled by polymer‐conjugated peptides 11, 12…”

Section: Introductionmentioning

confidence: 99%

Self‐Assembling Nanotubes Consisting of Rigid Cyclic γ‐Peptides

Zhan

Duan

et al. 2012

Adv Funct Materials

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Self‐assembling cyclic peptide nanotubes (SPNs) have been extensively studied due to their potential applications in biology and material sciences. Cyclic γ‐peptides, which have a larger conformational space, have received less attention than the cyclic α‐ and β‐peptides. The self‐assembly of cyclic homo‐γ‐tetrapeptide based on cis‐3‐aminocyclohexanecarboxylic acid (γ‐Ach) residues, which can be easily synthesized by a one‐pot process is investigated. Fourier transform infrared (FTIR) and NMR analysis along with density functional theory (DFT) calculations indicate that the cyclic homo‐γ‐tetrapeptide, with a non‐planar conformation, can self‐assemble into nanotubes through hydrogen‐bond‐mediated parallel stacking. Atomic force microscopy (AFM) and transmission electron microscopy (TEM) experiments reveal the formation of bundles of nanotubes in CH2Cl2/hexane, but individual nanotubes and bundles of only two nanotubes are obtained in water. The integration of TEG (triethylene glycol) monomethyl ether chains and cyclopeptide backbones may allow the control of width of single nanotubes.

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Synthesis and atomic force microscopy observations of the single-peptide nanotubes and their micro-order assemblies

Cited by 20 publications

References 11 publications

Peptide–Polymer Hybrid Nanotubes

Peptide–Polymer Hybrid Nanotubes

Nanotechnology on Duty in Medical Applications

Self‐Assembling Nanotubes Consisting of Rigid Cyclic γ‐Peptides

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